IMMUNOLOGICAL FEATURES OF ALLERGIC AND NON-ALLERGIC FORMS OF ATOPIC DERMATITIS

Abstract. In spite of similar clinical patterns, there are numerous differences in immunopathogenesis of intrinsiс and extrinsiс forms of atopic dermatitis. Patients with both forms have decreased levels of CD8+CD25+ lymphocytes, decreased telomere DNA length of CD4+T-cells, decreased migration inhi...

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Autores principales:	N. A. Shestakova, V. I. Borisov, N. V. Pronkina, E. V. Trufakina, I. V. Shishkova, D. V. Demina, M. I. Leonova, V. M. Nepomnyashikh, V. S. Kozhevnikov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	atopic dermatitis immunoglobulin е т-cells Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/980a7eb6e1734543958c7e8bb70f8695
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spelling	oai:doaj.org-article:980a7eb6e1734543958c7e8bb70f86952021-11-18T08:03:40ZIMMUNOLOGICAL FEATURES OF ALLERGIC AND NON-ALLERGIC FORMS OF ATOPIC DERMATITIS1563-06252313-741X10.15789/1563-0625-2009-6-531-540https://doaj.org/article/980a7eb6e1734543958c7e8bb70f86952014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/362https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. In spite of similar clinical patterns, there are numerous differences in immunopathogenesis of intrinsiс and extrinsiс forms of atopic dermatitis. Patients with both forms have decreased levels of CD8+CD25+ lymphocytes, decreased telomere DNA length of CD4+T-cells, decreased migration inhibition index in delayedtype hypersensitivity, decreased levels of CD16+NK-cells, decreased Fc-dependent monocyte and granulocyte phagocytosis, increased hydrogen peroxide production by neutrophils, increased levels of CD19+B-cells, as well as high IgA and IgG immunoglobulin levels. Extrinsiс form of atopic dermatitis are characterized by more severe clinical course, and by involvement of both immediate hypersensitivity (hyperproduction of IgE and decreased T-cells with intracellular IFNγ production), like as delayed-type hypersensitivity (decreased migration index along with decreased migration inhibition index). CD8+ play a large role in extrinsiс form of atopic dermatitis that may be traced as decreased telomere length of CD8+T- cells, decreased levels of CD8+CD45RO+ cells, increased levels of CD8+CD45RA+ naive cells and increased levels of CD28+ costimulatory molecules on CD8+cells. Increased levels of CD4+CD25+bright cells and strongly alterations of innate immunity determined of decreased H2O2 production by monocytes are shown in extrinsiс form. Hence, the severity index of atopic dermatitis is more expressed in extrinsic form of bronchial asthma and it is, probably, determined by more exaggerated immunological alterations.N. A. ShestakovaV. I. BorisovN. V. PronkinaE. V. TrufakinaI. V. ShishkovaD. V. DeminaM. I. LeonovaV. M. NepomnyashikhV. S. KozhevnikovSPb RAACIarticleatopic dermatitisimmunoglobulin ет-cellsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 11, Iss 6, Pp 531-540 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	atopic dermatitis immunoglobulin е т-cells Immunologic diseases. Allergy RC581-607
spellingShingle	atopic dermatitis immunoglobulin е т-cells Immunologic diseases. Allergy RC581-607 N. A. Shestakova V. I. Borisov N. V. Pronkina E. V. Trufakina I. V. Shishkova D. V. Demina M. I. Leonova V. M. Nepomnyashikh V. S. Kozhevnikov IMMUNOLOGICAL FEATURES OF ALLERGIC AND NON-ALLERGIC FORMS OF ATOPIC DERMATITIS
description	Abstract. In spite of similar clinical patterns, there are numerous differences in immunopathogenesis of intrinsiс and extrinsiс forms of atopic dermatitis. Patients with both forms have decreased levels of CD8+CD25+ lymphocytes, decreased telomere DNA length of CD4+T-cells, decreased migration inhibition index in delayedtype hypersensitivity, decreased levels of CD16+NK-cells, decreased Fc-dependent monocyte and granulocyte phagocytosis, increased hydrogen peroxide production by neutrophils, increased levels of CD19+B-cells, as well as high IgA and IgG immunoglobulin levels. Extrinsiс form of atopic dermatitis are characterized by more severe clinical course, and by involvement of both immediate hypersensitivity (hyperproduction of IgE and decreased T-cells with intracellular IFNγ production), like as delayed-type hypersensitivity (decreased migration index along with decreased migration inhibition index). CD8+ play a large role in extrinsiс form of atopic dermatitis that may be traced as decreased telomere length of CD8+T- cells, decreased levels of CD8+CD45RO+ cells, increased levels of CD8+CD45RA+ naive cells and increased levels of CD28+ costimulatory molecules on CD8+cells. Increased levels of CD4+CD25+bright cells and strongly alterations of innate immunity determined of decreased H2O2 production by monocytes are shown in extrinsiс form. Hence, the severity index of atopic dermatitis is more expressed in extrinsic form of bronchial asthma and it is, probably, determined by more exaggerated immunological alterations.
format	article
author	N. A. Shestakova V. I. Borisov N. V. Pronkina E. V. Trufakina I. V. Shishkova D. V. Demina M. I. Leonova V. M. Nepomnyashikh V. S. Kozhevnikov
author_facet	N. A. Shestakova V. I. Borisov N. V. Pronkina E. V. Trufakina I. V. Shishkova D. V. Demina M. I. Leonova V. M. Nepomnyashikh V. S. Kozhevnikov
author_sort	N. A. Shestakova
title	IMMUNOLOGICAL FEATURES OF ALLERGIC AND NON-ALLERGIC FORMS OF ATOPIC DERMATITIS
title_short	IMMUNOLOGICAL FEATURES OF ALLERGIC AND NON-ALLERGIC FORMS OF ATOPIC DERMATITIS
title_full	IMMUNOLOGICAL FEATURES OF ALLERGIC AND NON-ALLERGIC FORMS OF ATOPIC DERMATITIS
title_fullStr	IMMUNOLOGICAL FEATURES OF ALLERGIC AND NON-ALLERGIC FORMS OF ATOPIC DERMATITIS
title_full_unstemmed	IMMUNOLOGICAL FEATURES OF ALLERGIC AND NON-ALLERGIC FORMS OF ATOPIC DERMATITIS
title_sort	immunological features of allergic and non-allergic forms of atopic dermatitis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/980a7eb6e1734543958c7e8bb70f8695
work_keys_str_mv	AT nashestakova immunologicalfeaturesofallergicandnonallergicformsofatopicdermatitis AT viborisov immunologicalfeaturesofallergicandnonallergicformsofatopicdermatitis AT nvpronkina immunologicalfeaturesofallergicandnonallergicformsofatopicdermatitis AT evtrufakina immunologicalfeaturesofallergicandnonallergicformsofatopicdermatitis AT ivshishkova immunologicalfeaturesofallergicandnonallergicformsofatopicdermatitis AT dvdemina immunologicalfeaturesofallergicandnonallergicformsofatopicdermatitis AT mileonova immunologicalfeaturesofallergicandnonallergicformsofatopicdermatitis AT vmnepomnyashikh immunologicalfeaturesofallergicandnonallergicformsofatopicdermatitis AT vskozhevnikov immunologicalfeaturesofallergicandnonallergicformsofatopicdermatitis
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IMMUNOLOGICAL FEATURES OF ALLERGIC AND NON-ALLERGIC FORMS OF ATOPIC DERMATITIS

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