Catalytic enantioselective addition of organometallics to unprotected carboxylic acids
Unprotected carboxylic acids are classically deemed to be unsusceptible to conjugated additions due to acid-base neutralization. Here, the authors show that the use of an appropriate Lewis acid allows the catalytic addition of organometallics to unprotected carboxylic acids, also in an asymmetric fa...
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| Autores principales: | , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2019
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/980c9689b5454a49ae25f93afb67071e |
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| Sumario: | Unprotected carboxylic acids are classically deemed to be unsusceptible to conjugated additions due to acid-base neutralization. Here, the authors show that the use of an appropriate Lewis acid allows the catalytic addition of organometallics to unprotected carboxylic acids, also in an asymmetric fashion. |
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