Catalytic enantioselective addition of organometallics to unprotected carboxylic acids

Unprotected carboxylic acids are classically deemed to be unsusceptible to conjugated additions due to acid-base neutralization. Here, the authors show that the use of an appropriate Lewis acid allows the catalytic addition of organometallics to unprotected carboxylic acids, also in an asymmetric fa...

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Autores principales:	Xingchen Yan, Syuzanna R. Harutyunyan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/980c9689b5454a49ae25f93afb67071e
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spelling	oai:doaj.org-article:980c9689b5454a49ae25f93afb67071e2021-12-02T15:35:08ZCatalytic enantioselective addition of organometallics to unprotected carboxylic acids10.1038/s41467-019-11345-z2041-1723https://doaj.org/article/980c9689b5454a49ae25f93afb67071e2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11345-zhttps://doaj.org/toc/2041-1723Unprotected carboxylic acids are classically deemed to be unsusceptible to conjugated additions due to acid-base neutralization. Here, the authors show that the use of an appropriate Lewis acid allows the catalytic addition of organometallics to unprotected carboxylic acids, also in an asymmetric fashion.Xingchen YanSyuzanna R. HarutyunyanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xingchen Yan Syuzanna R. Harutyunyan Catalytic enantioselective addition of organometallics to unprotected carboxylic acids
description	Unprotected carboxylic acids are classically deemed to be unsusceptible to conjugated additions due to acid-base neutralization. Here, the authors show that the use of an appropriate Lewis acid allows the catalytic addition of organometallics to unprotected carboxylic acids, also in an asymmetric fashion.
format	article
author	Xingchen Yan Syuzanna R. Harutyunyan
author_facet	Xingchen Yan Syuzanna R. Harutyunyan
author_sort	Xingchen Yan
title	Catalytic enantioselective addition of organometallics to unprotected carboxylic acids
title_short	Catalytic enantioselective addition of organometallics to unprotected carboxylic acids
title_full	Catalytic enantioselective addition of organometallics to unprotected carboxylic acids
title_fullStr	Catalytic enantioselective addition of organometallics to unprotected carboxylic acids
title_full_unstemmed	Catalytic enantioselective addition of organometallics to unprotected carboxylic acids
title_sort	catalytic enantioselective addition of organometallics to unprotected carboxylic acids
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/980c9689b5454a49ae25f93afb67071e
work_keys_str_mv	AT xingchenyan catalyticenantioselectiveadditionoforganometallicstounprotectedcarboxylicacids AT syuzannarharutyunyan catalyticenantioselectiveadditionoforganometallicstounprotectedcarboxylicacids
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Catalytic enantioselective addition of organometallics to unprotected carboxylic acids

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