High-Accuracy Determination of Potassium and Selenium in Human Serum by Two-Step Isotope Dilution ICPMS

A high-accuracy measurement technique for determining potassium and selenium in human serum was developed by using two-step Isotope Dilution Inductively Coupled Plasma-Mass Spectrometry (ICPMS) in this research. A more accessible method of the quadrupole ICPMS was employed in this research to achiev...

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Autores principales:	Jian Yang, Lixia Chi, Shengmin Li
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Analytical chemistry QD71-142
Acceso en línea:	https://doaj.org/article/98126d33a9114f0dae66fbfc15a9dc0c
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spelling	oai:doaj.org-article:98126d33a9114f0dae66fbfc15a9dc0c2021-11-15T01:19:04ZHigh-Accuracy Determination of Potassium and Selenium in Human Serum by Two-Step Isotope Dilution ICPMS2090-887310.1155/2021/5533631https://doaj.org/article/98126d33a9114f0dae66fbfc15a9dc0c2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/5533631https://doaj.org/toc/2090-8873A high-accuracy measurement technique for determining potassium and selenium in human serum was developed by using two-step Isotope Dilution Inductively Coupled Plasma-Mass Spectrometry (ICPMS) in this research. A more accessible method of the quadrupole ICPMS was employed in this research to achieve an equally high accuracy which had been achieved by a much more expensive method, namely, high-resolution sector field ICPMS (SF-ICPMS), with a comparatively easy and simple operation. In addition, we have evaluated the uncertainty of this method. The results showed that the determination limits of potassium and selenium in serum were 0.8 mg/kg and 2.7 μg/kg, respectively, and the precision for both measurements was lower than 0.2% and 0.7%. The measurement, when employed to measure potassium and selenium in standard materials NIST956D, NIST909C, and GBW09152, had caused a maximum deviation of less than 0.9%, within the stated uncertainty range of standard materials. The RELA international inter-laboratory comparisons of potassium in serum in 2018 conducted by our laboratory also yielded a satisfactory result.Jian YangLixia ChiShengmin LiHindawi LimitedarticleAnalytical chemistryQD71-142ENJournal of Analytical Methods in Chemistry, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Analytical chemistry QD71-142
spellingShingle	Analytical chemistry QD71-142 Jian Yang Lixia Chi Shengmin Li High-Accuracy Determination of Potassium and Selenium in Human Serum by Two-Step Isotope Dilution ICPMS
description	A high-accuracy measurement technique for determining potassium and selenium in human serum was developed by using two-step Isotope Dilution Inductively Coupled Plasma-Mass Spectrometry (ICPMS) in this research. A more accessible method of the quadrupole ICPMS was employed in this research to achieve an equally high accuracy which had been achieved by a much more expensive method, namely, high-resolution sector field ICPMS (SF-ICPMS), with a comparatively easy and simple operation. In addition, we have evaluated the uncertainty of this method. The results showed that the determination limits of potassium and selenium in serum were 0.8 mg/kg and 2.7 μg/kg, respectively, and the precision for both measurements was lower than 0.2% and 0.7%. The measurement, when employed to measure potassium and selenium in standard materials NIST956D, NIST909C, and GBW09152, had caused a maximum deviation of less than 0.9%, within the stated uncertainty range of standard materials. The RELA international inter-laboratory comparisons of potassium in serum in 2018 conducted by our laboratory also yielded a satisfactory result.
format	article
author	Jian Yang Lixia Chi Shengmin Li
author_facet	Jian Yang Lixia Chi Shengmin Li
author_sort	Jian Yang
title	High-Accuracy Determination of Potassium and Selenium in Human Serum by Two-Step Isotope Dilution ICPMS
title_short	High-Accuracy Determination of Potassium and Selenium in Human Serum by Two-Step Isotope Dilution ICPMS
title_full	High-Accuracy Determination of Potassium and Selenium in Human Serum by Two-Step Isotope Dilution ICPMS
title_fullStr	High-Accuracy Determination of Potassium and Selenium in Human Serum by Two-Step Isotope Dilution ICPMS
title_full_unstemmed	High-Accuracy Determination of Potassium and Selenium in Human Serum by Two-Step Isotope Dilution ICPMS
title_sort	high-accuracy determination of potassium and selenium in human serum by two-step isotope dilution icpms
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/98126d33a9114f0dae66fbfc15a9dc0c
work_keys_str_mv	AT jianyang highaccuracydeterminationofpotassiumandseleniuminhumanserumbytwostepisotopedilutionicpms AT lixiachi highaccuracydeterminationofpotassiumandseleniuminhumanserumbytwostepisotopedilutionicpms AT shengminli highaccuracydeterminationofpotassiumandseleniuminhumanserumbytwostepisotopedilutionicpms
_version_	1718428998247120896

High-Accuracy Determination of Potassium and Selenium in Human Serum by Two-Step Isotope Dilution ICPMS

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