High peritoneal KT/V and peritonitis rates are associated with peritoneal calcification.

<h4>Background</h4>Peritoneal calcification (PC) is a specific finding in patients undergoing peritoneal dialysis (PD), but its prevalence, risk factors, and impacts in PD patients remain unclear. The present study investigated these issues and provided information useful for the managem...

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Autores principales:	Jenq-Wen Huang, Yu-Chung Lien, Chung-Yi Yang, Kao-Lang Liu, Cheng-Chung Fang, Cho-Kai Wu, Jen-Kuang Lee, Hon-Yen Wu, Chih-Kang Chiang, Hui-Teng Cheng, Chung-Jen Yen, Kuan-Yu Hung
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/98147a04f6ce457e97986ae366226c50
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spelling	oai:doaj.org-article:98147a04f6ce457e97986ae366226c502021-11-18T08:59:07ZHigh peritoneal KT/V and peritonitis rates are associated with peritoneal calcification.1932-620310.1371/journal.pone.0071636https://doaj.org/article/98147a04f6ce457e97986ae366226c502013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23977097/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Peritoneal calcification (PC) is a specific finding in patients undergoing peritoneal dialysis (PD), but its prevalence, risk factors, and impacts in PD patients remain unclear. The present study investigated these issues and provided information useful for the management of PC.<h4>Methods</h4>The study included 183 PD patients. The severity of PC was determined using abdominal computed tomography (CT), and we summed up all scores from slices obtained from the diaphragm to the pelvic floor normalized to body surface area. We analyzed the associations between PC and demographic and clinical characteristics, and between PC and levels of biomarkers, including C-reactive protein (CRP), osteoprotegrin and fetuin-A. The determinants of PC were examined using multiple regression analysis.<h4>Results</h4>Patients were categorized into group 1 (without PC, n = 133) and group 2 (with PC, n = 50). Group 2 patients showed different degrees of PC with a mean of 160±769 mm(2)/m(2). Group 1 patients had higher fetuin-A levels than group 2 patients (861±309 vs. 760±210 µg/mL; p = 0.021). The independent risk factors for the presence of PC included male gender, previous peritonitis, and PD adequacy (KT/V). Further analysis performed in group 2 patients showed that the dosage of vitamin D, serum levels of CRP, and dialysate calcium load were the independent determinants of PC. However, the presence of PC did not affect patients' technique survival, peritonitis incidence, or mortality in the mean follow up period of 28±12 months.<h4>Conclusions</h4>The presence and severity of PC were associated with inflammation, peritoneal KT/V, and mineral metabolism. The impact of PC on the outcomes of PD patients requires further study with a longer follow-up.Jenq-Wen HuangYu-Chung LienChung-Yi YangKao-Lang LiuCheng-Chung FangCho-Kai WuJen-Kuang LeeHon-Yen WuChih-Kang ChiangHui-Teng ChengChung-Jen YenKuan-Yu HungPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 8, p e71636 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jenq-Wen Huang Yu-Chung Lien Chung-Yi Yang Kao-Lang Liu Cheng-Chung Fang Cho-Kai Wu Jen-Kuang Lee Hon-Yen Wu Chih-Kang Chiang Hui-Teng Cheng Chung-Jen Yen Kuan-Yu Hung High peritoneal KT/V and peritonitis rates are associated with peritoneal calcification.
description	<h4>Background</h4>Peritoneal calcification (PC) is a specific finding in patients undergoing peritoneal dialysis (PD), but its prevalence, risk factors, and impacts in PD patients remain unclear. The present study investigated these issues and provided information useful for the management of PC.<h4>Methods</h4>The study included 183 PD patients. The severity of PC was determined using abdominal computed tomography (CT), and we summed up all scores from slices obtained from the diaphragm to the pelvic floor normalized to body surface area. We analyzed the associations between PC and demographic and clinical characteristics, and between PC and levels of biomarkers, including C-reactive protein (CRP), osteoprotegrin and fetuin-A. The determinants of PC were examined using multiple regression analysis.<h4>Results</h4>Patients were categorized into group 1 (without PC, n = 133) and group 2 (with PC, n = 50). Group 2 patients showed different degrees of PC with a mean of 160±769 mm(2)/m(2). Group 1 patients had higher fetuin-A levels than group 2 patients (861±309 vs. 760±210 µg/mL; p = 0.021). The independent risk factors for the presence of PC included male gender, previous peritonitis, and PD adequacy (KT/V). Further analysis performed in group 2 patients showed that the dosage of vitamin D, serum levels of CRP, and dialysate calcium load were the independent determinants of PC. However, the presence of PC did not affect patients' technique survival, peritonitis incidence, or mortality in the mean follow up period of 28±12 months.<h4>Conclusions</h4>The presence and severity of PC were associated with inflammation, peritoneal KT/V, and mineral metabolism. The impact of PC on the outcomes of PD patients requires further study with a longer follow-up.
format	article
author	Jenq-Wen Huang Yu-Chung Lien Chung-Yi Yang Kao-Lang Liu Cheng-Chung Fang Cho-Kai Wu Jen-Kuang Lee Hon-Yen Wu Chih-Kang Chiang Hui-Teng Cheng Chung-Jen Yen Kuan-Yu Hung
author_facet	Jenq-Wen Huang Yu-Chung Lien Chung-Yi Yang Kao-Lang Liu Cheng-Chung Fang Cho-Kai Wu Jen-Kuang Lee Hon-Yen Wu Chih-Kang Chiang Hui-Teng Cheng Chung-Jen Yen Kuan-Yu Hung
author_sort	Jenq-Wen Huang
title	High peritoneal KT/V and peritonitis rates are associated with peritoneal calcification.
title_short	High peritoneal KT/V and peritonitis rates are associated with peritoneal calcification.
title_full	High peritoneal KT/V and peritonitis rates are associated with peritoneal calcification.
title_fullStr	High peritoneal KT/V and peritonitis rates are associated with peritoneal calcification.
title_full_unstemmed	High peritoneal KT/V and peritonitis rates are associated with peritoneal calcification.
title_sort	high peritoneal kt/v and peritonitis rates are associated with peritoneal calcification.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/98147a04f6ce457e97986ae366226c50
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High peritoneal KT/V and peritonitis rates are associated with peritoneal calcification.

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