Storax, A Promising Botanical Medicine for Treating Cardio-Cerebrovascular Diseases: A Review

In recent years, the incidence and mortality of cardio-cerebrovascular diseases have been increasing year by year, which has become global burden and challenge. Based on the holistic thinking of “brain disease affects the heart” and “heart disease affects the brain,” as well as the characteristics o...

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Autores principales:	Zhuo Xu, Danni Lu, Jianmei Yuan, Mihong Ren, Rong Ma, Qian Xie, Yong Li, Jinxiu Li, Jian Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	storax cardio-cerebrovascular diseases chemical composition pharmacological activities cerebral and cardiac treatment synchronously Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/98156ce066794d81965c0e18060a33ec
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spelling	oai:doaj.org-article:98156ce066794d81965c0e18060a33ec2021-12-01T18:47:08ZStorax, A Promising Botanical Medicine for Treating Cardio-Cerebrovascular Diseases: A Review1663-981210.3389/fphar.2021.785598https://doaj.org/article/98156ce066794d81965c0e18060a33ec2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.785598/fullhttps://doaj.org/toc/1663-9812In recent years, the incidence and mortality of cardio-cerebrovascular diseases have been increasing year by year, which has become global burden and challenge. Based on the holistic thinking of “brain disease affects the heart” and “heart disease affects the brain,” as well as the characteristics of multi-target and multi-path effects of Chinese medicine, Chinese medicine is more advantageous in the treatment of cardio-cerebrovascular diseases. As a botanical medicine, storax is known for its resuscitation, filth avoidance and pain-relieving effects in the treatment of cardio-cerebrovascular diseases. By reviewing and collating the relevant domestic and international literature in the past 10 years, we have sorted out an overview of the medicinal parts, traditional uses and chemical composition of storax. For the first time, based on the idea of “cerebral and cardiac simultaneous treatment,” the pharmacological activities and mechanisms of heart and brain protection of storax for treating cardio-cerebrovascular diseases were summarized and analyzed, showing that storax has the pharmacological effects of anti-cerebral ischemia, regulation of blood-brain barrier, bidirectional regulation of the central nervous system, anti-myocardial ischemia, anti-arrhythmia, anti-thrombosis and anti-platelet aggregation. It mainly exerts its protective effects on the brain and heart through mechanisms such as inhibition of inflammatory immune factors, anti-oxidative stress, anti-apoptosis, pro-neovascularization and regulation of NO release. On the basis of the current findings and limitations, the future research strategies and perspectives of storax are proposed, with a view to providing a reference for further application and development of this medicine, as well as contributing new thoughts and visions for the clinical application of “treating brain-heart synchronously”.Zhuo XuDanni LuJianmei YuanMihong RenRong MaQian XieYong LiJinxiu LiJian WangFrontiers Media S.A.articlestoraxcardio-cerebrovascular diseaseschemical compositionpharmacological activitiescerebral and cardiac treatment synchronouslyTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	storax cardio-cerebrovascular diseases chemical composition pharmacological activities cerebral and cardiac treatment synchronously Therapeutics. Pharmacology RM1-950
spellingShingle	storax cardio-cerebrovascular diseases chemical composition pharmacological activities cerebral and cardiac treatment synchronously Therapeutics. Pharmacology RM1-950 Zhuo Xu Danni Lu Jianmei Yuan Mihong Ren Rong Ma Qian Xie Yong Li Jinxiu Li Jian Wang Storax, A Promising Botanical Medicine for Treating Cardio-Cerebrovascular Diseases: A Review
description	In recent years, the incidence and mortality of cardio-cerebrovascular diseases have been increasing year by year, which has become global burden and challenge. Based on the holistic thinking of “brain disease affects the heart” and “heart disease affects the brain,” as well as the characteristics of multi-target and multi-path effects of Chinese medicine, Chinese medicine is more advantageous in the treatment of cardio-cerebrovascular diseases. As a botanical medicine, storax is known for its resuscitation, filth avoidance and pain-relieving effects in the treatment of cardio-cerebrovascular diseases. By reviewing and collating the relevant domestic and international literature in the past 10 years, we have sorted out an overview of the medicinal parts, traditional uses and chemical composition of storax. For the first time, based on the idea of “cerebral and cardiac simultaneous treatment,” the pharmacological activities and mechanisms of heart and brain protection of storax for treating cardio-cerebrovascular diseases were summarized and analyzed, showing that storax has the pharmacological effects of anti-cerebral ischemia, regulation of blood-brain barrier, bidirectional regulation of the central nervous system, anti-myocardial ischemia, anti-arrhythmia, anti-thrombosis and anti-platelet aggregation. It mainly exerts its protective effects on the brain and heart through mechanisms such as inhibition of inflammatory immune factors, anti-oxidative stress, anti-apoptosis, pro-neovascularization and regulation of NO release. On the basis of the current findings and limitations, the future research strategies and perspectives of storax are proposed, with a view to providing a reference for further application and development of this medicine, as well as contributing new thoughts and visions for the clinical application of “treating brain-heart synchronously”.
format	article
author	Zhuo Xu Danni Lu Jianmei Yuan Mihong Ren Rong Ma Qian Xie Yong Li Jinxiu Li Jian Wang
author_facet	Zhuo Xu Danni Lu Jianmei Yuan Mihong Ren Rong Ma Qian Xie Yong Li Jinxiu Li Jian Wang
author_sort	Zhuo Xu
title	Storax, A Promising Botanical Medicine for Treating Cardio-Cerebrovascular Diseases: A Review
title_short	Storax, A Promising Botanical Medicine for Treating Cardio-Cerebrovascular Diseases: A Review
title_full	Storax, A Promising Botanical Medicine for Treating Cardio-Cerebrovascular Diseases: A Review
title_fullStr	Storax, A Promising Botanical Medicine for Treating Cardio-Cerebrovascular Diseases: A Review
title_full_unstemmed	Storax, A Promising Botanical Medicine for Treating Cardio-Cerebrovascular Diseases: A Review
title_sort	storax, a promising botanical medicine for treating cardio-cerebrovascular diseases: a review
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/98156ce066794d81965c0e18060a33ec
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Storax, A Promising Botanical Medicine for Treating Cardio-Cerebrovascular Diseases: A Review

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