Repurposing endogenous immune pathways to tailor and control chimeric antigen receptor T cell functionality

Engineered T cells work as living therapeutics, but are prone to hyperreactivity and exhaustion. Here the authors improve CAR T cell antitumor responses by simultaneously targeting a CAR to TCR locus and IL-12 to PD1 locus, placing the transgenes under a naturally regulated transcriptional network w...

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Autores principales:	Mohit Sachdeva, Brian W. Busser, Sonal Temburni, Billal Jahangiri, Anne-Sophie Gautron, Alan Maréchal, Alexandre Juillerat, Alan Williams, Stéphane Depil, Philippe Duchateau, Laurent Poirot, Julien Valton
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/981675c72a9b4f029d140df08e0be5fe
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spelling	oai:doaj.org-article:981675c72a9b4f029d140df08e0be5fe2021-12-02T15:35:05ZRepurposing endogenous immune pathways to tailor and control chimeric antigen receptor T cell functionality10.1038/s41467-019-13088-32041-1723https://doaj.org/article/981675c72a9b4f029d140df08e0be5fe2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13088-3https://doaj.org/toc/2041-1723Engineered T cells work as living therapeutics, but are prone to hyperreactivity and exhaustion. Here the authors improve CAR T cell antitumor responses by simultaneously targeting a CAR to TCR locus and IL-12 to PD1 locus, placing the transgenes under a naturally regulated transcriptional network while disrupting unwanted signals.Mohit SachdevaBrian W. BusserSonal TemburniBillal JahangiriAnne-Sophie GautronAlan MaréchalAlexandre JuilleratAlan WilliamsStéphane DepilPhilippe DuchateauLaurent PoirotJulien ValtonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mohit Sachdeva Brian W. Busser Sonal Temburni Billal Jahangiri Anne-Sophie Gautron Alan Maréchal Alexandre Juillerat Alan Williams Stéphane Depil Philippe Duchateau Laurent Poirot Julien Valton Repurposing endogenous immune pathways to tailor and control chimeric antigen receptor T cell functionality
description	Engineered T cells work as living therapeutics, but are prone to hyperreactivity and exhaustion. Here the authors improve CAR T cell antitumor responses by simultaneously targeting a CAR to TCR locus and IL-12 to PD1 locus, placing the transgenes under a naturally regulated transcriptional network while disrupting unwanted signals.
format	article
author	Mohit Sachdeva Brian W. Busser Sonal Temburni Billal Jahangiri Anne-Sophie Gautron Alan Maréchal Alexandre Juillerat Alan Williams Stéphane Depil Philippe Duchateau Laurent Poirot Julien Valton
author_facet	Mohit Sachdeva Brian W. Busser Sonal Temburni Billal Jahangiri Anne-Sophie Gautron Alan Maréchal Alexandre Juillerat Alan Williams Stéphane Depil Philippe Duchateau Laurent Poirot Julien Valton
author_sort	Mohit Sachdeva
title	Repurposing endogenous immune pathways to tailor and control chimeric antigen receptor T cell functionality
title_short	Repurposing endogenous immune pathways to tailor and control chimeric antigen receptor T cell functionality
title_full	Repurposing endogenous immune pathways to tailor and control chimeric antigen receptor T cell functionality
title_fullStr	Repurposing endogenous immune pathways to tailor and control chimeric antigen receptor T cell functionality
title_full_unstemmed	Repurposing endogenous immune pathways to tailor and control chimeric antigen receptor T cell functionality
title_sort	repurposing endogenous immune pathways to tailor and control chimeric antigen receptor t cell functionality
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/981675c72a9b4f029d140df08e0be5fe
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Repurposing endogenous immune pathways to tailor and control chimeric antigen receptor T cell functionality

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