Peripheral BDNF and psycho-behavioral aspects are positively modulated by high-intensity intermittent exercise and fitness in healthy women

Abstract Acute high-intensity intermittent exercise (HIIE) induces the myokine secretion associated with neurogenesis, as well brain-derived neurotrophic factor (BDNF); however, it remains unknown how the menstrual phase influences this secretion after an acute exercise session. The current study ai...

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Autores principales:	Rodrigo Araujo Bonetti de Poli, Vithor Hugo Fialho Lopes, Fábio Santos Lira, Alessandro Moura Zagatto, Alberto Jimenez-Maldonado, Barbara Moura Antunes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9816e5ae74504cfb9117c04d60b68f3b
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spelling	oai:doaj.org-article:9816e5ae74504cfb9117c04d60b68f3b2021-12-02T10:54:23ZPeripheral BDNF and psycho-behavioral aspects are positively modulated by high-intensity intermittent exercise and fitness in healthy women10.1038/s41598-021-83072-92045-2322https://doaj.org/article/9816e5ae74504cfb9117c04d60b68f3b2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83072-9https://doaj.org/toc/2045-2322Abstract Acute high-intensity intermittent exercise (HIIE) induces the myokine secretion associated with neurogenesis, as well brain-derived neurotrophic factor (BDNF); however, it remains unknown how the menstrual phase influences this secretion after an acute exercise session. The current study aimed to investigate the effects of HIIE performed in luteal and follicular menstrual phases on BDNF, cognitive function, mood, and exercise enjoyment. Fourteen healthy women completed four experimental sessions, randomly. One graded exercise test (GXT) and one HIIE session (10 × 1-min runs 90% peak GXT velocity [1-min recovery]) were performed for each menstrual phase. Blood samples were collected at rest and immediately after efforts, and the profile of mood states questionnaire (POMS) and Stroop-task test were applied. During the HIIE, subjective scales were applied (feeling, felt arousal, rate of perceived exertion, and physical activity enjoyment). The main results showed that the serum BDNF presented no difference between menstrual phases (p = 0.870); however, HIIE increased BDNF concentration in both menstrual phases (p = 0.030). In addition, the magnitude of circulating BDNF variation (Δ%BDNF) and $$\dot{\text{V}}{{\text{O}}}_{\text{2max}}$$ V ˙ O 2max demonstrated an inverse relationship in the follicular phase (r = − 0.539, p = 0.046), whereas in the luteal phase, Δ%BDNF was negatively correlated with time test (r = − 0.684, p = 0.007) and RPE (r = − 0.726, p = 0.004) in GXT. No differences between menstrual phases were observed for POMS (p ≥ 0.05); however, HIIE attenuated tension (p < 0.01), depression (p < 0.01), and anger moods (p < 0.01), independently of menstrual phases. The subjective scales and Stroop-task test did not show differences. In conclusion, menstrual cycle phase does not affect serum BDNF levels, cognitive function, mood, and exercise enjoyment. Contrary, HIIE increases peripheral BDNF and attenuates tension, depression, and anger independently of menstrual phase. In addition, Δ%BDNF was correlated with physical fitness in the follicular phase, exhibiting higher changes in women with lower physical fitness status.Rodrigo Araujo Bonetti de PoliVithor Hugo Fialho LopesFábio Santos LiraAlessandro Moura ZagattoAlberto Jimenez-MaldonadoBarbara Moura AntunesNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rodrigo Araujo Bonetti de Poli Vithor Hugo Fialho Lopes Fábio Santos Lira Alessandro Moura Zagatto Alberto Jimenez-Maldonado Barbara Moura Antunes Peripheral BDNF and psycho-behavioral aspects are positively modulated by high-intensity intermittent exercise and fitness in healthy women
description	Abstract Acute high-intensity intermittent exercise (HIIE) induces the myokine secretion associated with neurogenesis, as well brain-derived neurotrophic factor (BDNF); however, it remains unknown how the menstrual phase influences this secretion after an acute exercise session. The current study aimed to investigate the effects of HIIE performed in luteal and follicular menstrual phases on BDNF, cognitive function, mood, and exercise enjoyment. Fourteen healthy women completed four experimental sessions, randomly. One graded exercise test (GXT) and one HIIE session (10 × 1-min runs 90% peak GXT velocity [1-min recovery]) were performed for each menstrual phase. Blood samples were collected at rest and immediately after efforts, and the profile of mood states questionnaire (POMS) and Stroop-task test were applied. During the HIIE, subjective scales were applied (feeling, felt arousal, rate of perceived exertion, and physical activity enjoyment). The main results showed that the serum BDNF presented no difference between menstrual phases (p = 0.870); however, HIIE increased BDNF concentration in both menstrual phases (p = 0.030). In addition, the magnitude of circulating BDNF variation (Δ%BDNF) and $$\dot{\text{V}}{{\text{O}}}_{\text{2max}}$$ V ˙ O 2max demonstrated an inverse relationship in the follicular phase (r = − 0.539, p = 0.046), whereas in the luteal phase, Δ%BDNF was negatively correlated with time test (r = − 0.684, p = 0.007) and RPE (r = − 0.726, p = 0.004) in GXT. No differences between menstrual phases were observed for POMS (p ≥ 0.05); however, HIIE attenuated tension (p < 0.01), depression (p < 0.01), and anger moods (p < 0.01), independently of menstrual phases. The subjective scales and Stroop-task test did not show differences. In conclusion, menstrual cycle phase does not affect serum BDNF levels, cognitive function, mood, and exercise enjoyment. Contrary, HIIE increases peripheral BDNF and attenuates tension, depression, and anger independently of menstrual phase. In addition, Δ%BDNF was correlated with physical fitness in the follicular phase, exhibiting higher changes in women with lower physical fitness status.
format	article
author	Rodrigo Araujo Bonetti de Poli Vithor Hugo Fialho Lopes Fábio Santos Lira Alessandro Moura Zagatto Alberto Jimenez-Maldonado Barbara Moura Antunes
author_facet	Rodrigo Araujo Bonetti de Poli Vithor Hugo Fialho Lopes Fábio Santos Lira Alessandro Moura Zagatto Alberto Jimenez-Maldonado Barbara Moura Antunes
author_sort	Rodrigo Araujo Bonetti de Poli
title	Peripheral BDNF and psycho-behavioral aspects are positively modulated by high-intensity intermittent exercise and fitness in healthy women
title_short	Peripheral BDNF and psycho-behavioral aspects are positively modulated by high-intensity intermittent exercise and fitness in healthy women
title_full	Peripheral BDNF and psycho-behavioral aspects are positively modulated by high-intensity intermittent exercise and fitness in healthy women
title_fullStr	Peripheral BDNF and psycho-behavioral aspects are positively modulated by high-intensity intermittent exercise and fitness in healthy women
title_full_unstemmed	Peripheral BDNF and psycho-behavioral aspects are positively modulated by high-intensity intermittent exercise and fitness in healthy women
title_sort	peripheral bdnf and psycho-behavioral aspects are positively modulated by high-intensity intermittent exercise and fitness in healthy women
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9816e5ae74504cfb9117c04d60b68f3b
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Peripheral BDNF and psycho-behavioral aspects are positively modulated by high-intensity intermittent exercise and fitness in healthy women

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