EFFECTS OF THE FUNDAMENTAL PROPERTIES OF AMPICILLIN RAW MATERIAL IN THE DERIVATIVE PROPERTIES

Antimicrobial agents often generate doubts concerning their therapeutic effects; it is not infrequent to find differences in the clinical effectiveness among products of the same active principle made by different laboratories. It is, therefore, necessary to carry out studies as to the reasons of su...

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Autores principales:	Julie F. BENAVIDES A., Esther J. IBARRA J., Érica J. OBANDO M., Juliana PÉREZ L., Gloria E. TOBÓN Z., Óscar A. FLÓREZ A.
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2009
Materias:	Ampicillin fundamental properties derivative properties dissolution profiles similarity factor inhibiting minimum concentration. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/9818403ee5db4989b335978932006d5f
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spelling	oai:doaj.org-article:9818403ee5db4989b335978932006d5f2021-11-19T04:21:47ZEFFECTS OF THE FUNDAMENTAL PROPERTIES OF AMPICILLIN RAW MATERIAL IN THE DERIVATIVE PROPERTIES0121-40042145-2660https://doaj.org/article/9818403ee5db4989b335978932006d5f2009-02-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/566https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660Antimicrobial agents often generate doubts concerning their therapeutic effects; it is not infrequent to find differences in the clinical effectiveness among products of the same active principle made by different laboratories. It is, therefore, necessary to carry out studies as to the reasons of such variations in order to reduce or eliminate differences in the therapeutic products. We evaluated the fundamental characteristics (external form, internal structure, and physical and chemical identification) of ampicillin powder using a trade name product (powder in capsules), a generic one (powder in capsules), as well as different crystalline forms of the raw material (also in powder), obtained by recrystallization in different solvents at room temperature. After determining the fundamental properties of the aforementioned solids, they were compared on the basis of the results obtained in their derivative properties such as the dissolution profiles analyzed by means of the difference and similarity factors (f1, f2), and the antimicrobial effectiveness indexes by means of the minimal inhibitory concentration (MIC). Julie F. BENAVIDES A.Esther J. IBARRA J.Érica J. OBANDO M.Juliana PÉREZ L.Gloria E. TOBÓN Z.Óscar A. FLÓREZ A.Universidad de AntioquiaarticleAmpicillinfundamental propertiesderivative propertiesdissolution profilessimilarity factorinhibiting minimum concentration.Food processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 14, Iss 1 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ampicillin fundamental properties derivative properties dissolution profiles similarity factor inhibiting minimum concentration. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	Ampicillin fundamental properties derivative properties dissolution profiles similarity factor inhibiting minimum concentration. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Julie F. BENAVIDES A. Esther J. IBARRA J. Érica J. OBANDO M. Juliana PÉREZ L. Gloria E. TOBÓN Z. Óscar A. FLÓREZ A. EFFECTS OF THE FUNDAMENTAL PROPERTIES OF AMPICILLIN RAW MATERIAL IN THE DERIVATIVE PROPERTIES
description	Antimicrobial agents often generate doubts concerning their therapeutic effects; it is not infrequent to find differences in the clinical effectiveness among products of the same active principle made by different laboratories. It is, therefore, necessary to carry out studies as to the reasons of such variations in order to reduce or eliminate differences in the therapeutic products. We evaluated the fundamental characteristics (external form, internal structure, and physical and chemical identification) of ampicillin powder using a trade name product (powder in capsules), a generic one (powder in capsules), as well as different crystalline forms of the raw material (also in powder), obtained by recrystallization in different solvents at room temperature. After determining the fundamental properties of the aforementioned solids, they were compared on the basis of the results obtained in their derivative properties such as the dissolution profiles analyzed by means of the difference and similarity factors (f1, f2), and the antimicrobial effectiveness indexes by means of the minimal inhibitory concentration (MIC).
format	article
author	Julie F. BENAVIDES A. Esther J. IBARRA J. Érica J. OBANDO M. Juliana PÉREZ L. Gloria E. TOBÓN Z. Óscar A. FLÓREZ A.
author_facet	Julie F. BENAVIDES A. Esther J. IBARRA J. Érica J. OBANDO M. Juliana PÉREZ L. Gloria E. TOBÓN Z. Óscar A. FLÓREZ A.
author_sort	Julie F. BENAVIDES A.
title	EFFECTS OF THE FUNDAMENTAL PROPERTIES OF AMPICILLIN RAW MATERIAL IN THE DERIVATIVE PROPERTIES
title_short	EFFECTS OF THE FUNDAMENTAL PROPERTIES OF AMPICILLIN RAW MATERIAL IN THE DERIVATIVE PROPERTIES
title_full	EFFECTS OF THE FUNDAMENTAL PROPERTIES OF AMPICILLIN RAW MATERIAL IN THE DERIVATIVE PROPERTIES
title_fullStr	EFFECTS OF THE FUNDAMENTAL PROPERTIES OF AMPICILLIN RAW MATERIAL IN THE DERIVATIVE PROPERTIES
title_full_unstemmed	EFFECTS OF THE FUNDAMENTAL PROPERTIES OF AMPICILLIN RAW MATERIAL IN THE DERIVATIVE PROPERTIES
title_sort	effects of the fundamental properties of ampicillin raw material in the derivative properties
publisher	Universidad de Antioquia
publishDate	2009
url	https://doaj.org/article/9818403ee5db4989b335978932006d5f
work_keys_str_mv	AT juliefbenavidesa effectsofthefundamentalpropertiesofampicillinrawmaterialinthederivativeproperties AT estherjibarraj effectsofthefundamentalpropertiesofampicillinrawmaterialinthederivativeproperties AT ericajobandom effectsofthefundamentalpropertiesofampicillinrawmaterialinthederivativeproperties AT julianaperezl effectsofthefundamentalpropertiesofampicillinrawmaterialinthederivativeproperties AT gloriaetobonz effectsofthefundamentalpropertiesofampicillinrawmaterialinthederivativeproperties AT oscarafloreza effectsofthefundamentalpropertiesofampicillinrawmaterialinthederivativeproperties
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EFFECTS OF THE FUNDAMENTAL PROPERTIES OF AMPICILLIN RAW MATERIAL IN THE DERIVATIVE PROPERTIES

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