A role for soluble ST2 in vascular remodeling associated with obesity in rats.

<h4>Background</h4>The function of the Interleukin-33 (IL-33)/ST2 system has been mainly investigated on immunological aspects, but recent data suggest that this pathway plays also an important role in cardiovascular system and adipose tissue. Whereas IL-33 has been demonstrated to exert...

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Autores principales:	Ernesto Martínez-Martínez, María Miana, Raquel Jurado-López, Elodie Rousseau, Patrick Rossignol, Faiez Zannad, Victoria Cachofeiro, Natalia López-Andrés
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/98186f0a215c447a9e54d23f101a2c9f
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spelling	oai:doaj.org-article:98186f0a215c447a9e54d23f101a2c9f2021-11-18T08:47:06ZA role for soluble ST2 in vascular remodeling associated with obesity in rats.1932-620310.1371/journal.pone.0079176https://doaj.org/article/98186f0a215c447a9e54d23f101a2c9f2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24265755/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The function of the Interleukin-33 (IL-33)/ST2 system has been mainly investigated on immunological aspects, but recent data suggest that this pathway plays also an important role in cardiovascular system and adipose tissue. Whereas IL-33 has been demonstrated to exert anti-inflammatory and protective effects, circulating soluble ST2 (sST2) has emerged as a prognostic biomarker in patients with myocardial infarction and heart failure. Furthermore, sST2 is increased in severe obesity, although its role in the pathogenesis of vascular remodeling associated with obesity is still not well defined.<h4>Methodology/principal findings</h4>Male Wistar rats fed standard diet (Control) or high fat diet (HFD) for 6 weeks. Aortic tunica media from diet-induced obese animals showed hypertrophy and fibrosis. The IL-33/ST2 system was spontaneously expressed in the aorta from Wistar rats. Administration of HFD in animals did not modify IL-33 expression at the transcriptional level. By contrast, HFD group showed an increase in aortic soluble sST2 and a decrease in the transmembrane isoform (ST2L) levels, resulting in decreased protective pathway activity. Aortic sST2 mRNA levels were associated with parameters showing vascular hypertrophy and fibrosis. In vitro experiments showed that primary cultured vascular smooth muscle cells (VSMCs) spontaneously expressed the IL-33/ST2 system. VSMCs stimulated with sST2 showed an increase in collagen type I, fibronectin and profibrotic factors.<h4>Conclusions</h4>This is the first study demonstrating a deleterious role for sST2 in the vascular remodeling associated with obesity. In addition, we demonstrated that sST2 may act not only as a decoy receptor by binding IL-33 and preventing ST2L, but also modulating ECM remodeling and turnover. Thus, sST2 could be a new therapeutic target to reduce vascular remodeling in the context of obesity.Ernesto Martínez-MartínezMaría MianaRaquel Jurado-LópezElodie RousseauPatrick RossignolFaiez ZannadVictoria CachofeiroNatalia López-AndrésPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e79176 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ernesto Martínez-Martínez María Miana Raquel Jurado-López Elodie Rousseau Patrick Rossignol Faiez Zannad Victoria Cachofeiro Natalia López-Andrés A role for soluble ST2 in vascular remodeling associated with obesity in rats.
description	<h4>Background</h4>The function of the Interleukin-33 (IL-33)/ST2 system has been mainly investigated on immunological aspects, but recent data suggest that this pathway plays also an important role in cardiovascular system and adipose tissue. Whereas IL-33 has been demonstrated to exert anti-inflammatory and protective effects, circulating soluble ST2 (sST2) has emerged as a prognostic biomarker in patients with myocardial infarction and heart failure. Furthermore, sST2 is increased in severe obesity, although its role in the pathogenesis of vascular remodeling associated with obesity is still not well defined.<h4>Methodology/principal findings</h4>Male Wistar rats fed standard diet (Control) or high fat diet (HFD) for 6 weeks. Aortic tunica media from diet-induced obese animals showed hypertrophy and fibrosis. The IL-33/ST2 system was spontaneously expressed in the aorta from Wistar rats. Administration of HFD in animals did not modify IL-33 expression at the transcriptional level. By contrast, HFD group showed an increase in aortic soluble sST2 and a decrease in the transmembrane isoform (ST2L) levels, resulting in decreased protective pathway activity. Aortic sST2 mRNA levels were associated with parameters showing vascular hypertrophy and fibrosis. In vitro experiments showed that primary cultured vascular smooth muscle cells (VSMCs) spontaneously expressed the IL-33/ST2 system. VSMCs stimulated with sST2 showed an increase in collagen type I, fibronectin and profibrotic factors.<h4>Conclusions</h4>This is the first study demonstrating a deleterious role for sST2 in the vascular remodeling associated with obesity. In addition, we demonstrated that sST2 may act not only as a decoy receptor by binding IL-33 and preventing ST2L, but also modulating ECM remodeling and turnover. Thus, sST2 could be a new therapeutic target to reduce vascular remodeling in the context of obesity.
format	article
author	Ernesto Martínez-Martínez María Miana Raquel Jurado-López Elodie Rousseau Patrick Rossignol Faiez Zannad Victoria Cachofeiro Natalia López-Andrés
author_facet	Ernesto Martínez-Martínez María Miana Raquel Jurado-López Elodie Rousseau Patrick Rossignol Faiez Zannad Victoria Cachofeiro Natalia López-Andrés
author_sort	Ernesto Martínez-Martínez
title	A role for soluble ST2 in vascular remodeling associated with obesity in rats.
title_short	A role for soluble ST2 in vascular remodeling associated with obesity in rats.
title_full	A role for soluble ST2 in vascular remodeling associated with obesity in rats.
title_fullStr	A role for soluble ST2 in vascular remodeling associated with obesity in rats.
title_full_unstemmed	A role for soluble ST2 in vascular remodeling associated with obesity in rats.
title_sort	role for soluble st2 in vascular remodeling associated with obesity in rats.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/98186f0a215c447a9e54d23f101a2c9f
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A role for soluble ST2 in vascular remodeling associated with obesity in rats.

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