Pericyte-expressed Tie2 controls angiogenesis and vessel maturation

The angiopoietins regulate vascular maturation, angiogenesis and lymphangiogenesis via their Tie receptors that were long believed to be endothelium-specific. Here the authors show that angiopoietins activate and control pericyte function through pericyte-expressed Tie2 triggering of Calpain, Akt an...

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Autores principales:	Martin Teichert, Laura Milde, Annegret Holm, Laura Stanicek, Nicolas Gengenbacher, Soniya Savant, Tina Ruckdeschel, Zulfiyya Hasanov, Kshitij Srivastava, Junhao Hu, Stella Hertel, Arne Bartol, Katharina Schlereth, Hellmut G. Augustin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/981a987e79e44cc08ee1f10a3f710c40
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spelling	oai:doaj.org-article:981a987e79e44cc08ee1f10a3f710c402021-12-02T17:06:23ZPericyte-expressed Tie2 controls angiogenesis and vessel maturation10.1038/ncomms161062041-1723https://doaj.org/article/981a987e79e44cc08ee1f10a3f710c402017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms16106https://doaj.org/toc/2041-1723The angiopoietins regulate vascular maturation, angiogenesis and lymphangiogenesis via their Tie receptors that were long believed to be endothelium-specific. Here the authors show that angiopoietins activate and control pericyte function through pericyte-expressed Tie2 triggering of Calpain, Akt and FOXO3A signalling cascades.Martin TeichertLaura MildeAnnegret HolmLaura StanicekNicolas GengenbacherSoniya SavantTina RuckdeschelZulfiyya HasanovKshitij SrivastavaJunhao HuStella HertelArne BartolKatharina SchlerethHellmut G. AugustinNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Martin Teichert Laura Milde Annegret Holm Laura Stanicek Nicolas Gengenbacher Soniya Savant Tina Ruckdeschel Zulfiyya Hasanov Kshitij Srivastava Junhao Hu Stella Hertel Arne Bartol Katharina Schlereth Hellmut G. Augustin Pericyte-expressed Tie2 controls angiogenesis and vessel maturation
description	The angiopoietins regulate vascular maturation, angiogenesis and lymphangiogenesis via their Tie receptors that were long believed to be endothelium-specific. Here the authors show that angiopoietins activate and control pericyte function through pericyte-expressed Tie2 triggering of Calpain, Akt and FOXO3A signalling cascades.
format	article
author	Martin Teichert Laura Milde Annegret Holm Laura Stanicek Nicolas Gengenbacher Soniya Savant Tina Ruckdeschel Zulfiyya Hasanov Kshitij Srivastava Junhao Hu Stella Hertel Arne Bartol Katharina Schlereth Hellmut G. Augustin
author_facet	Martin Teichert Laura Milde Annegret Holm Laura Stanicek Nicolas Gengenbacher Soniya Savant Tina Ruckdeschel Zulfiyya Hasanov Kshitij Srivastava Junhao Hu Stella Hertel Arne Bartol Katharina Schlereth Hellmut G. Augustin
author_sort	Martin Teichert
title	Pericyte-expressed Tie2 controls angiogenesis and vessel maturation
title_short	Pericyte-expressed Tie2 controls angiogenesis and vessel maturation
title_full	Pericyte-expressed Tie2 controls angiogenesis and vessel maturation
title_fullStr	Pericyte-expressed Tie2 controls angiogenesis and vessel maturation
title_full_unstemmed	Pericyte-expressed Tie2 controls angiogenesis and vessel maturation
title_sort	pericyte-expressed tie2 controls angiogenesis and vessel maturation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/981a987e79e44cc08ee1f10a3f710c40
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Pericyte-expressed Tie2 controls angiogenesis and vessel maturation

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