Lipoteichoic acid deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae

Teichoic acid is bound to peptidoglycan (wall teichoic acid, WTA) or to membrane glycolipids (lipoteichoic acid, LTA) in most Gram-positive bacteria. Here, the authors identify a putative ligase required for the assembly of LTA, but not WTA, and important for Streptococcus pneumoniae virulence in mo...

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Autores principales:	Nathalie Heß, Franziska Waldow, Thomas P. Kohler, Manfred Rohde, Bernd Kreikemeyer, Alejandro Gómez-Mejia, Torsten Hain, Dominik Schwudke, Waldemar Vollmer, Sven Hammerschmidt, Nicolas Gisch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/981ad421dad041efb626412019f1aa32
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spelling	oai:doaj.org-article:981ad421dad041efb626412019f1aa322021-12-02T17:06:27ZLipoteichoic acid deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae10.1038/s41467-017-01720-z2041-1723https://doaj.org/article/981ad421dad041efb626412019f1aa322017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01720-zhttps://doaj.org/toc/2041-1723Teichoic acid is bound to peptidoglycan (wall teichoic acid, WTA) or to membrane glycolipids (lipoteichoic acid, LTA) in most Gram-positive bacteria. Here, the authors identify a putative ligase required for the assembly of LTA, but not WTA, and important for Streptococcus pneumoniae virulence in mouse models.Nathalie HeßFranziska WaldowThomas P. KohlerManfred RohdeBernd KreikemeyerAlejandro Gómez-MejiaTorsten HainDominik SchwudkeWaldemar VollmerSven HammerschmidtNicolas GischNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nathalie Heß Franziska Waldow Thomas P. Kohler Manfred Rohde Bernd Kreikemeyer Alejandro Gómez-Mejia Torsten Hain Dominik Schwudke Waldemar Vollmer Sven Hammerschmidt Nicolas Gisch Lipoteichoic acid deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae
description	Teichoic acid is bound to peptidoglycan (wall teichoic acid, WTA) or to membrane glycolipids (lipoteichoic acid, LTA) in most Gram-positive bacteria. Here, the authors identify a putative ligase required for the assembly of LTA, but not WTA, and important for Streptococcus pneumoniae virulence in mouse models.
format	article
author	Nathalie Heß Franziska Waldow Thomas P. Kohler Manfred Rohde Bernd Kreikemeyer Alejandro Gómez-Mejia Torsten Hain Dominik Schwudke Waldemar Vollmer Sven Hammerschmidt Nicolas Gisch
author_facet	Nathalie Heß Franziska Waldow Thomas P. Kohler Manfred Rohde Bernd Kreikemeyer Alejandro Gómez-Mejia Torsten Hain Dominik Schwudke Waldemar Vollmer Sven Hammerschmidt Nicolas Gisch
author_sort	Nathalie Heß
title	Lipoteichoic acid deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae
title_short	Lipoteichoic acid deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae
title_full	Lipoteichoic acid deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae
title_fullStr	Lipoteichoic acid deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae
title_full_unstemmed	Lipoteichoic acid deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae
title_sort	lipoteichoic acid deficiency permits normal growth but impairs virulence of streptococcus pneumoniae
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/981ad421dad041efb626412019f1aa32
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Lipoteichoic acid deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae

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