Bacterial polyphosphates interfere with the innate host defense to infection

Production of polyphosphate polymers is a ubiquitous trait of bacteria. Here, the authors investigate the role of bacterial long polyphosphates in host immune suppression and show that long polyphosphates produced by E. coli inhibit LPS-mediated inflammation and bacterial clearance in mice.

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Autores principales:	Julian Roewe, Georgios Stavrides, Marcel Strueve, Arjun Sharma, Federico Marini, Amrit Mann, Stephanie A. Smith, Ziya Kaya, Birgit Strobl, Mathias Mueller, Christoph Reinhardt, James H. Morrissey, Markus Bosmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/981bd424c2f4496e8c311fc4f1a08f66
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spelling	oai:doaj.org-article:981bd424c2f4496e8c311fc4f1a08f662021-12-02T16:27:46ZBacterial polyphosphates interfere with the innate host defense to infection10.1038/s41467-020-17639-x2041-1723https://doaj.org/article/981bd424c2f4496e8c311fc4f1a08f662020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17639-xhttps://doaj.org/toc/2041-1723Production of polyphosphate polymers is a ubiquitous trait of bacteria. Here, the authors investigate the role of bacterial long polyphosphates in host immune suppression and show that long polyphosphates produced by E. coli inhibit LPS-mediated inflammation and bacterial clearance in mice.Julian RoeweGeorgios StavridesMarcel StrueveArjun SharmaFederico MariniAmrit MannStephanie A. SmithZiya KayaBirgit StroblMathias MuellerChristoph ReinhardtJames H. MorrisseyMarkus BosmannNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Julian Roewe Georgios Stavrides Marcel Strueve Arjun Sharma Federico Marini Amrit Mann Stephanie A. Smith Ziya Kaya Birgit Strobl Mathias Mueller Christoph Reinhardt James H. Morrissey Markus Bosmann Bacterial polyphosphates interfere with the innate host defense to infection
description	Production of polyphosphate polymers is a ubiquitous trait of bacteria. Here, the authors investigate the role of bacterial long polyphosphates in host immune suppression and show that long polyphosphates produced by E. coli inhibit LPS-mediated inflammation and bacterial clearance in mice.
format	article
author	Julian Roewe Georgios Stavrides Marcel Strueve Arjun Sharma Federico Marini Amrit Mann Stephanie A. Smith Ziya Kaya Birgit Strobl Mathias Mueller Christoph Reinhardt James H. Morrissey Markus Bosmann
author_facet	Julian Roewe Georgios Stavrides Marcel Strueve Arjun Sharma Federico Marini Amrit Mann Stephanie A. Smith Ziya Kaya Birgit Strobl Mathias Mueller Christoph Reinhardt James H. Morrissey Markus Bosmann
author_sort	Julian Roewe
title	Bacterial polyphosphates interfere with the innate host defense to infection
title_short	Bacterial polyphosphates interfere with the innate host defense to infection
title_full	Bacterial polyphosphates interfere with the innate host defense to infection
title_fullStr	Bacterial polyphosphates interfere with the innate host defense to infection
title_full_unstemmed	Bacterial polyphosphates interfere with the innate host defense to infection
title_sort	bacterial polyphosphates interfere with the innate host defense to infection
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/981bd424c2f4496e8c311fc4f1a08f66
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Bacterial polyphosphates interfere with the innate host defense to infection

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