Fluticasone/salmeterol reduces remodelling and neutrophilic inflammation in severe equine asthma

Abstract Asthmatic airways are inflamed and undergo remodelling. Inhaled corticosteroids and long-acting β2-agonist combinations are more effective than inhaled corticosteroid monotherapy in controlling disease exacerbations, but their effect on airway remodelling and inflammation remains ill-define...

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Autores principales:	Michela Bullone, Amandine Vargas, Yvonne Elce, James G. Martin, Jean-Pierre Lavoie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/981ce9bea29742fe8978f57af06377de
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spelling	oai:doaj.org-article:981ce9bea29742fe8978f57af06377de2021-12-02T15:05:57ZFluticasone/salmeterol reduces remodelling and neutrophilic inflammation in severe equine asthma10.1038/s41598-017-09414-82045-2322https://doaj.org/article/981ce9bea29742fe8978f57af06377de2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09414-8https://doaj.org/toc/2045-2322Abstract Asthmatic airways are inflamed and undergo remodelling. Inhaled corticosteroids and long-acting β2-agonist combinations are more effective than inhaled corticosteroid monotherapy in controlling disease exacerbations, but their effect on airway remodelling and inflammation remains ill-defined. This study evaluates the contribution of inhaled fluticasone and salmeterol, alone or combined, to the reversal of bronchial remodelling and inflammation. Severely asthmatic horses (6 horses/group) were treated with fluticasone, salmeterol, fluticasone/salmeterol, or with antigen avoidance for 12 weeks. Lung function, central and peripheral airway remodelling, and bronchoalveolar inflammation were assessed. Fluticasone/salmeterol and fluticasone monotherapy decreased peripheral airway smooth muscle remodelling after 12 weeks (p = 0.007 and p = 0.02, respectively). On average, a 30% decrease was observed with both treatments. In central airways, fluticasone/salmeterol reversed extracellular matrix remodelling after 12 weeks, both within the lamina propria (decreased thickness, p = 0.005) and within the smooth muscle layer (p = 0.004). Only fluticasone/salmeterol decreased bronchoalveolar neutrophilia (p = 0.03) to the same extent as antigen avoidance already after 8 weeks. In conclusion, this study shows that fluticasone/salmeterol combination decreases extracellular matrix remodelling in central airways and intraluminal neutrophilia. Fluticasone/salmeterol and fluticasone monotherapy equally reverse peripheral airway smooth muscle remodelling.Michela BulloneAmandine VargasYvonne ElceJames G. MartinJean-Pierre LavoieNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michela Bullone Amandine Vargas Yvonne Elce James G. Martin Jean-Pierre Lavoie Fluticasone/salmeterol reduces remodelling and neutrophilic inflammation in severe equine asthma
description	Abstract Asthmatic airways are inflamed and undergo remodelling. Inhaled corticosteroids and long-acting β2-agonist combinations are more effective than inhaled corticosteroid monotherapy in controlling disease exacerbations, but their effect on airway remodelling and inflammation remains ill-defined. This study evaluates the contribution of inhaled fluticasone and salmeterol, alone or combined, to the reversal of bronchial remodelling and inflammation. Severely asthmatic horses (6 horses/group) were treated with fluticasone, salmeterol, fluticasone/salmeterol, or with antigen avoidance for 12 weeks. Lung function, central and peripheral airway remodelling, and bronchoalveolar inflammation were assessed. Fluticasone/salmeterol and fluticasone monotherapy decreased peripheral airway smooth muscle remodelling after 12 weeks (p = 0.007 and p = 0.02, respectively). On average, a 30% decrease was observed with both treatments. In central airways, fluticasone/salmeterol reversed extracellular matrix remodelling after 12 weeks, both within the lamina propria (decreased thickness, p = 0.005) and within the smooth muscle layer (p = 0.004). Only fluticasone/salmeterol decreased bronchoalveolar neutrophilia (p = 0.03) to the same extent as antigen avoidance already after 8 weeks. In conclusion, this study shows that fluticasone/salmeterol combination decreases extracellular matrix remodelling in central airways and intraluminal neutrophilia. Fluticasone/salmeterol and fluticasone monotherapy equally reverse peripheral airway smooth muscle remodelling.
format	article
author	Michela Bullone Amandine Vargas Yvonne Elce James G. Martin Jean-Pierre Lavoie
author_facet	Michela Bullone Amandine Vargas Yvonne Elce James G. Martin Jean-Pierre Lavoie
author_sort	Michela Bullone
title	Fluticasone/salmeterol reduces remodelling and neutrophilic inflammation in severe equine asthma
title_short	Fluticasone/salmeterol reduces remodelling and neutrophilic inflammation in severe equine asthma
title_full	Fluticasone/salmeterol reduces remodelling and neutrophilic inflammation in severe equine asthma
title_fullStr	Fluticasone/salmeterol reduces remodelling and neutrophilic inflammation in severe equine asthma
title_full_unstemmed	Fluticasone/salmeterol reduces remodelling and neutrophilic inflammation in severe equine asthma
title_sort	fluticasone/salmeterol reduces remodelling and neutrophilic inflammation in severe equine asthma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/981ce9bea29742fe8978f57af06377de
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Fluticasone/salmeterol reduces remodelling and neutrophilic inflammation in severe equine asthma

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