Diversifying Arena of Drug Synthesis: In the Realm of Lipase Mediated Waves of Biocatalysis

Hydrolases, being most prominent enzymes used in industrial processes have left no stone unturned in fascinating the pharmaceutical industry. Lipases, being a part of acyl hydrolases are the ones that function similarly to esterases (except an interfacial action) wherein they generally catalyze the...

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Autores principales:	Sahil Verma, Rahul Narayanlal Choudhary, Akash Prakash Kanadje, Uttam Chand Banerjee
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hydrolases stereoselectivity regioselectivity biocatalysis nanobiotechnology Chemical technology TP1-1185 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/981dbb87c6a54b3fb2576376440241a0
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spelling	oai:doaj.org-article:981dbb87c6a54b3fb2576376440241a02021-11-25T17:05:57ZDiversifying Arena of Drug Synthesis: In the Realm of Lipase Mediated Waves of Biocatalysis10.3390/catal111113282073-4344https://doaj.org/article/981dbb87c6a54b3fb2576376440241a02021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4344/11/11/1328https://doaj.org/toc/2073-4344Hydrolases, being most prominent enzymes used in industrial processes have left no stone unturned in fascinating the pharmaceutical industry. Lipases, being a part of acyl hydrolases are the ones that function similarly to esterases (except an interfacial action) wherein they generally catalyze the hydrolysis of ester bonds. Be it in terms of stereoselectivity or regioselectivity, lipases have manifested their promiscuous proficiency in rendering biocatalytic drug synthesis and intermediates thereof. Industrial utilization of lipases is prevalent since decades ago, but their distinctive catalytic competencies have rendered them suitable for maneuverability in various tides of biocatalytic industrial process development. Numbers of exquisite catalysts have been fabricated out of lipases using nanobiotechnology whereby enzyme reusability and robustness have been conferred to many of the organic synthesis procedures. This marks a considerable achievement of lipases in the second wave of biocatalysis. Furthermore, in the third wave an advent of genetic engineering has fostered an era of customized lipases for suitable needs. Be it stability or an enhanced efficacy, genetic engineering techniques have ushered an avenue for biocatalytic development of drugs and drug intermediates through greener processes using lipases. Even in the forthcoming concept of co-modular catalytic systems, lipases may be the frontiers because of their astonishing capability to act along with other enzymes. The concept may render feasibility in the development of cascade reactions in organic synthesis. An upcoming wave demands fulfilling the vision of tailored lipase whilst a far-flung exploration needs to be unveiled for various research impediments in rendering lipase as a custom fit biocatalyst in pharmaceutical industry.Sahil VermaRahul Narayanlal ChoudharyAkash Prakash KanadjeUttam Chand BanerjeeMDPI AGarticlehydrolasesstereoselectivityregioselectivitybiocatalysisnanobiotechnologyChemical technologyTP1-1185ChemistryQD1-999ENCatalysts, Vol 11, Iss 1328, p 1328 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hydrolases stereoselectivity regioselectivity biocatalysis nanobiotechnology Chemical technology TP1-1185 Chemistry QD1-999
spellingShingle	hydrolases stereoselectivity regioselectivity biocatalysis nanobiotechnology Chemical technology TP1-1185 Chemistry QD1-999 Sahil Verma Rahul Narayanlal Choudhary Akash Prakash Kanadje Uttam Chand Banerjee Diversifying Arena of Drug Synthesis: In the Realm of Lipase Mediated Waves of Biocatalysis
description	Hydrolases, being most prominent enzymes used in industrial processes have left no stone unturned in fascinating the pharmaceutical industry. Lipases, being a part of acyl hydrolases are the ones that function similarly to esterases (except an interfacial action) wherein they generally catalyze the hydrolysis of ester bonds. Be it in terms of stereoselectivity or regioselectivity, lipases have manifested their promiscuous proficiency in rendering biocatalytic drug synthesis and intermediates thereof. Industrial utilization of lipases is prevalent since decades ago, but their distinctive catalytic competencies have rendered them suitable for maneuverability in various tides of biocatalytic industrial process development. Numbers of exquisite catalysts have been fabricated out of lipases using nanobiotechnology whereby enzyme reusability and robustness have been conferred to many of the organic synthesis procedures. This marks a considerable achievement of lipases in the second wave of biocatalysis. Furthermore, in the third wave an advent of genetic engineering has fostered an era of customized lipases for suitable needs. Be it stability or an enhanced efficacy, genetic engineering techniques have ushered an avenue for biocatalytic development of drugs and drug intermediates through greener processes using lipases. Even in the forthcoming concept of co-modular catalytic systems, lipases may be the frontiers because of their astonishing capability to act along with other enzymes. The concept may render feasibility in the development of cascade reactions in organic synthesis. An upcoming wave demands fulfilling the vision of tailored lipase whilst a far-flung exploration needs to be unveiled for various research impediments in rendering lipase as a custom fit biocatalyst in pharmaceutical industry.
format	article
author	Sahil Verma Rahul Narayanlal Choudhary Akash Prakash Kanadje Uttam Chand Banerjee
author_facet	Sahil Verma Rahul Narayanlal Choudhary Akash Prakash Kanadje Uttam Chand Banerjee
author_sort	Sahil Verma
title	Diversifying Arena of Drug Synthesis: In the Realm of Lipase Mediated Waves of Biocatalysis
title_short	Diversifying Arena of Drug Synthesis: In the Realm of Lipase Mediated Waves of Biocatalysis
title_full	Diversifying Arena of Drug Synthesis: In the Realm of Lipase Mediated Waves of Biocatalysis
title_fullStr	Diversifying Arena of Drug Synthesis: In the Realm of Lipase Mediated Waves of Biocatalysis
title_full_unstemmed	Diversifying Arena of Drug Synthesis: In the Realm of Lipase Mediated Waves of Biocatalysis
title_sort	diversifying arena of drug synthesis: in the realm of lipase mediated waves of biocatalysis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/981dbb87c6a54b3fb2576376440241a0
work_keys_str_mv	AT sahilverma diversifyingarenaofdrugsynthesisintherealmoflipasemediatedwavesofbiocatalysis AT rahulnarayanlalchoudhary diversifyingarenaofdrugsynthesisintherealmoflipasemediatedwavesofbiocatalysis AT akashprakashkanadje diversifyingarenaofdrugsynthesisintherealmoflipasemediatedwavesofbiocatalysis AT uttamchandbanerjee diversifyingarenaofdrugsynthesisintherealmoflipasemediatedwavesofbiocatalysis
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Diversifying Arena of Drug Synthesis: In the Realm of Lipase Mediated Waves of Biocatalysis

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