Feasibility, safety, and acceptability of a remotely monitored exercise pilot CHAMP: A Clinical trial of High‐intensity Aerobic and resistance exercise for Metastatic castrate‐resistant Prostate cancer

Abstract Background Exercise may improve clinical and quality of life outcomes for men with prostate cancer. No randomized controlled trials (RCTs) have examined the feasibility, safety, and acceptability of remote exercise training in men with metastatic castrate‐resistant prostate cancer (mCRPC)....

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Autores principales:	Stacey A. Kenfield, Erin L. Van Blarigan, Neil Panchal, Alexander Bang, Li Zhang, Rebecca E. Graff, Yea‐Hung Chen, Charles J. Ryan, Anthony Luke, Robert U. Newton, Imelda Tenggara, Brooke Schultz, Elizabeth Wang, Emil Lavaki, Kyle Zuniga, Nicole Pinto, Hala Borno, Rahul Aggarwal, Terence Friedlander, Vadim S. Koshkin, Andrea Harzstark, Eric Small, June M. Chan
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	behavioral intervention physical activity remote strength training Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/982224bbcd1e4eb59b14dd6c2b73ea74
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spelling	oai:doaj.org-article:982224bbcd1e4eb59b14dd6c2b73ea742021-11-22T09:08:48ZFeasibility, safety, and acceptability of a remotely monitored exercise pilot CHAMP: A Clinical trial of High‐intensity Aerobic and resistance exercise for Metastatic castrate‐resistant Prostate cancer2045-763410.1002/cam4.4324https://doaj.org/article/982224bbcd1e4eb59b14dd6c2b73ea742021-11-01T00:00:00Zhttps://doi.org/10.1002/cam4.4324https://doaj.org/toc/2045-7634Abstract Background Exercise may improve clinical and quality of life outcomes for men with prostate cancer. No randomized controlled trials (RCTs) have examined the feasibility, safety, and acceptability of remote exercise training in men with metastatic castrate‐resistant prostate cancer (mCRPC). Methods We conducted a pilot RCT (1:1:1 aerobic or resistance exercise 3x/week or usual care) to determine the feasibility, safety, and acceptability of remotely monitored exercise over 12 weeks in 25 men with mCRPC. A prescribed exercise program was based on baseline testing including high‐ and moderate‐intensity aerobic exercise or resistance exercise completed at a local exercise facility. Feasibility was based on attendance, adherence, and tolerance; safety on adverse events; and acceptability on participant interviews. Results Between March 2016 and March 2020, 25 patients were randomized (8 aerobic, 7 resistance, and 10 control). Twenty‐three men (82%) completed the 12‐week study. Men who completed the remote intervention attempted 90% and 96% of prescribed aerobic and resistance training sessions, respectively, and 86% and 88% of attempted sessions were completed as or more than prescribed. We observed changes in performance tests that corresponded with the exercise prescription. No safety concerns were identified. Ninety percent of participants interviewed were satisfied with the program and would recommend it to others. Conclusions Remotely monitored exercise training is feasible, safe, and acceptable in men with mCRPC; there was no difference in these outcomes by mode of exercise. Through this research, we provide direction and rationale for future studies of exercise and clinical outcomes in patients with metastatic prostate cancer.Stacey A. KenfieldErin L. Van BlariganNeil PanchalAlexander BangLi ZhangRebecca E. GraffYea‐Hung ChenCharles J. RyanAnthony LukeRobert U. NewtonImelda TenggaraBrooke SchultzElizabeth WangEmil LavakiKyle ZunigaNicole PintoHala BornoRahul AggarwalTerence FriedlanderVadim S. KoshkinAndrea HarzstarkEric SmallJune M. ChanWileyarticlebehavioral interventionphysical activityremotestrength trainingNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancer Medicine, Vol 10, Iss 22, Pp 8058-8070 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	behavioral intervention physical activity remote strength training Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	behavioral intervention physical activity remote strength training Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Stacey A. Kenfield Erin L. Van Blarigan Neil Panchal Alexander Bang Li Zhang Rebecca E. Graff Yea‐Hung Chen Charles J. Ryan Anthony Luke Robert U. Newton Imelda Tenggara Brooke Schultz Elizabeth Wang Emil Lavaki Kyle Zuniga Nicole Pinto Hala Borno Rahul Aggarwal Terence Friedlander Vadim S. Koshkin Andrea Harzstark Eric Small June M. Chan Feasibility, safety, and acceptability of a remotely monitored exercise pilot CHAMP: A Clinical trial of High‐intensity Aerobic and resistance exercise for Metastatic castrate‐resistant Prostate cancer
description	Abstract Background Exercise may improve clinical and quality of life outcomes for men with prostate cancer. No randomized controlled trials (RCTs) have examined the feasibility, safety, and acceptability of remote exercise training in men with metastatic castrate‐resistant prostate cancer (mCRPC). Methods We conducted a pilot RCT (1:1:1 aerobic or resistance exercise 3x/week or usual care) to determine the feasibility, safety, and acceptability of remotely monitored exercise over 12 weeks in 25 men with mCRPC. A prescribed exercise program was based on baseline testing including high‐ and moderate‐intensity aerobic exercise or resistance exercise completed at a local exercise facility. Feasibility was based on attendance, adherence, and tolerance; safety on adverse events; and acceptability on participant interviews. Results Between March 2016 and March 2020, 25 patients were randomized (8 aerobic, 7 resistance, and 10 control). Twenty‐three men (82%) completed the 12‐week study. Men who completed the remote intervention attempted 90% and 96% of prescribed aerobic and resistance training sessions, respectively, and 86% and 88% of attempted sessions were completed as or more than prescribed. We observed changes in performance tests that corresponded with the exercise prescription. No safety concerns were identified. Ninety percent of participants interviewed were satisfied with the program and would recommend it to others. Conclusions Remotely monitored exercise training is feasible, safe, and acceptable in men with mCRPC; there was no difference in these outcomes by mode of exercise. Through this research, we provide direction and rationale for future studies of exercise and clinical outcomes in patients with metastatic prostate cancer.
format	article
author	Stacey A. Kenfield Erin L. Van Blarigan Neil Panchal Alexander Bang Li Zhang Rebecca E. Graff Yea‐Hung Chen Charles J. Ryan Anthony Luke Robert U. Newton Imelda Tenggara Brooke Schultz Elizabeth Wang Emil Lavaki Kyle Zuniga Nicole Pinto Hala Borno Rahul Aggarwal Terence Friedlander Vadim S. Koshkin Andrea Harzstark Eric Small June M. Chan
author_facet	Stacey A. Kenfield Erin L. Van Blarigan Neil Panchal Alexander Bang Li Zhang Rebecca E. Graff Yea‐Hung Chen Charles J. Ryan Anthony Luke Robert U. Newton Imelda Tenggara Brooke Schultz Elizabeth Wang Emil Lavaki Kyle Zuniga Nicole Pinto Hala Borno Rahul Aggarwal Terence Friedlander Vadim S. Koshkin Andrea Harzstark Eric Small June M. Chan
author_sort	Stacey A. Kenfield
title	Feasibility, safety, and acceptability of a remotely monitored exercise pilot CHAMP: A Clinical trial of High‐intensity Aerobic and resistance exercise for Metastatic castrate‐resistant Prostate cancer
title_short	Feasibility, safety, and acceptability of a remotely monitored exercise pilot CHAMP: A Clinical trial of High‐intensity Aerobic and resistance exercise for Metastatic castrate‐resistant Prostate cancer
title_full	Feasibility, safety, and acceptability of a remotely monitored exercise pilot CHAMP: A Clinical trial of High‐intensity Aerobic and resistance exercise for Metastatic castrate‐resistant Prostate cancer
title_fullStr	Feasibility, safety, and acceptability of a remotely monitored exercise pilot CHAMP: A Clinical trial of High‐intensity Aerobic and resistance exercise for Metastatic castrate‐resistant Prostate cancer
title_full_unstemmed	Feasibility, safety, and acceptability of a remotely monitored exercise pilot CHAMP: A Clinical trial of High‐intensity Aerobic and resistance exercise for Metastatic castrate‐resistant Prostate cancer
title_sort	feasibility, safety, and acceptability of a remotely monitored exercise pilot champ: a clinical trial of high‐intensity aerobic and resistance exercise for metastatic castrate‐resistant prostate cancer
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/982224bbcd1e4eb59b14dd6c2b73ea74
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Feasibility, safety, and acceptability of a remotely monitored exercise pilot CHAMP: A Clinical trial of High‐intensity Aerobic and resistance exercise for Metastatic castrate‐resistant Prostate cancer

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