Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus
The WalKR signal transduction system is involved in extracellular signal recognition, but the details of this function are not well established. Here, the authors report the crystal structure of this two-component system alongside the characterisation of a small-molecule activator.
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Nature Portfolio
2016
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oai:doaj.org-article:982278f7c02745b09c2db25ee3867b432021-12-02T17:33:19ZStructure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus10.1038/ncomms110002041-1723https://doaj.org/article/982278f7c02745b09c2db25ee3867b432016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms11000https://doaj.org/toc/2041-1723The WalKR signal transduction system is involved in extracellular signal recognition, but the details of this function are not well established. Here, the authors report the crystal structure of this two-component system alongside the characterisation of a small-molecule activator.Quanjiang JiPeter J. ChenGuangrong QinXin DengZiyang HaoZdzislaw WawrzakWon-Sik YeoJenny Winjing QuangHoonsik ChoGuan-Zheng LuoXiaocheng WengQiancheng YouChi-Hao LuanXiaojing YangTaeok BaeKunqian YuHualiang JiangChuan HeNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Quanjiang Ji Peter J. Chen Guangrong Qin Xin Deng Ziyang Hao Zdzislaw Wawrzak Won-Sik Yeo Jenny Winjing Quang Hoonsik Cho Guan-Zheng Luo Xiaocheng Weng Qiancheng You Chi-Hao Luan Xiaojing Yang Taeok Bae Kunqian Yu Hualiang Jiang Chuan He Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus |
| description |
The WalKR signal transduction system is involved in extracellular signal recognition, but the details of this function are not well established. Here, the authors report the crystal structure of this two-component system alongside the characterisation of a small-molecule activator. |
| format |
article |
| author |
Quanjiang Ji Peter J. Chen Guangrong Qin Xin Deng Ziyang Hao Zdzislaw Wawrzak Won-Sik Yeo Jenny Winjing Quang Hoonsik Cho Guan-Zheng Luo Xiaocheng Weng Qiancheng You Chi-Hao Luan Xiaojing Yang Taeok Bae Kunqian Yu Hualiang Jiang Chuan He |
| author_facet |
Quanjiang Ji Peter J. Chen Guangrong Qin Xin Deng Ziyang Hao Zdzislaw Wawrzak Won-Sik Yeo Jenny Winjing Quang Hoonsik Cho Guan-Zheng Luo Xiaocheng Weng Qiancheng You Chi-Hao Luan Xiaojing Yang Taeok Bae Kunqian Yu Hualiang Jiang Chuan He |
| author_sort |
Quanjiang Ji |
| title |
Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus |
| title_short |
Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus |
| title_full |
Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus |
| title_fullStr |
Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus |
| title_full_unstemmed |
Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus |
| title_sort |
structure and mechanism of the essential two-component signal-transduction system walkr in staphylococcus aureus |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/982278f7c02745b09c2db25ee3867b43 |
| work_keys_str_mv |
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1718380013263257600 |