VHL deficiency augments anthracycline sensitivity of clear cell renal cell carcinomas by down-regulating ALDH2

The VHL tumour suppressor gene is lost in approximately 70% of clear cell renal cell carcinoma (ccRCC). In this study, the authors demonstrate that VHL loss in these tumours augments anthracyclines chemotherapy by down-regulation of ALDH2.

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Auteurs principaux:	Yao-Hui Gao, Zhao-Xia Wu, Li-Qi Xie, Cai-Xia Li, Yu-Qin Mao, Yan-Tao Duan, Bing Han, San-Feng Han, Yun Yu, Hao-Jie Lu, Peng-Yuan Yang, Tian-Rui Xu, Jing-Lin Xia, Guo-Qiang Chen, Li-Shun Wang
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/9824cfd7e32e4b21864e7a4abbc4a3f2
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spelling	oai:doaj.org-article:9824cfd7e32e4b21864e7a4abbc4a3f22021-12-02T17:06:28ZVHL deficiency augments anthracycline sensitivity of clear cell renal cell carcinomas by down-regulating ALDH210.1038/ncomms153372041-1723https://doaj.org/article/9824cfd7e32e4b21864e7a4abbc4a3f22017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15337https://doaj.org/toc/2041-1723The VHL tumour suppressor gene is lost in approximately 70% of clear cell renal cell carcinoma (ccRCC). In this study, the authors demonstrate that VHL loss in these tumours augments anthracyclines chemotherapy by down-regulation of ALDH2.Yao-Hui GaoZhao-Xia WuLi-Qi XieCai-Xia LiYu-Qin MaoYan-Tao DuanBing HanSan-Feng HanYun YuHao-Jie LuPeng-Yuan YangTian-Rui XuJing-Lin XiaGuo-Qiang ChenLi-Shun WangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yao-Hui Gao Zhao-Xia Wu Li-Qi Xie Cai-Xia Li Yu-Qin Mao Yan-Tao Duan Bing Han San-Feng Han Yun Yu Hao-Jie Lu Peng-Yuan Yang Tian-Rui Xu Jing-Lin Xia Guo-Qiang Chen Li-Shun Wang VHL deficiency augments anthracycline sensitivity of clear cell renal cell carcinomas by down-regulating ALDH2
description	The VHL tumour suppressor gene is lost in approximately 70% of clear cell renal cell carcinoma (ccRCC). In this study, the authors demonstrate that VHL loss in these tumours augments anthracyclines chemotherapy by down-regulation of ALDH2.
format	article
author	Yao-Hui Gao Zhao-Xia Wu Li-Qi Xie Cai-Xia Li Yu-Qin Mao Yan-Tao Duan Bing Han San-Feng Han Yun Yu Hao-Jie Lu Peng-Yuan Yang Tian-Rui Xu Jing-Lin Xia Guo-Qiang Chen Li-Shun Wang
author_facet	Yao-Hui Gao Zhao-Xia Wu Li-Qi Xie Cai-Xia Li Yu-Qin Mao Yan-Tao Duan Bing Han San-Feng Han Yun Yu Hao-Jie Lu Peng-Yuan Yang Tian-Rui Xu Jing-Lin Xia Guo-Qiang Chen Li-Shun Wang
author_sort	Yao-Hui Gao
title	VHL deficiency augments anthracycline sensitivity of clear cell renal cell carcinomas by down-regulating ALDH2
title_short	VHL deficiency augments anthracycline sensitivity of clear cell renal cell carcinomas by down-regulating ALDH2
title_full	VHL deficiency augments anthracycline sensitivity of clear cell renal cell carcinomas by down-regulating ALDH2
title_fullStr	VHL deficiency augments anthracycline sensitivity of clear cell renal cell carcinomas by down-regulating ALDH2
title_full_unstemmed	VHL deficiency augments anthracycline sensitivity of clear cell renal cell carcinomas by down-regulating ALDH2
title_sort	vhl deficiency augments anthracycline sensitivity of clear cell renal cell carcinomas by down-regulating aldh2
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9824cfd7e32e4b21864e7a4abbc4a3f2
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VHL deficiency augments anthracycline sensitivity of clear cell renal cell carcinomas by down-regulating ALDH2

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