Effect of the Structural and Morphological Properties of Surfactant-Assisted Hydroxyapatite on Dermal Irritation and Antibacterial Activity

Hydroxyapatite (HAp) nanoparticles with a homogeneous rod morphology were successfully synthesized using the hydrothermal method. The powders were characterized using Fourier transform infrared spectroscopy, X-ray diffraction, and scanning electron microscopy. The antibacterial and dermal irritation...

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Autores principales:	Giovanni García Domínguez, Sebastián Diaz De La Torre, Lorena Chávez Güitrón, Erasto Vergara Hernández, Joan Reyes Miranda, Maribel Quezada Cruz, Aristeo Garrido Hernández
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hydroxyapatite nanorods antibacterial activity hydrothermal surfactant Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
Acceso en línea:	https://doaj.org/article/98261b3b18324c8988b19ec741271267
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spelling	oai:doaj.org-article:98261b3b18324c8988b19ec7412712672021-11-11T18:05:14ZEffect of the Structural and Morphological Properties of Surfactant-Assisted Hydroxyapatite on Dermal Irritation and Antibacterial Activity10.3390/ma142165221996-1944https://doaj.org/article/98261b3b18324c8988b19ec7412712672021-10-01T00:00:00Zhttps://www.mdpi.com/1996-1944/14/21/6522https://doaj.org/toc/1996-1944Hydroxyapatite (HAp) nanoparticles with a homogeneous rod morphology were successfully synthesized using the hydrothermal method. The powders were characterized using Fourier transform infrared spectroscopy, X-ray diffraction, and scanning electron microscopy. The antibacterial and dermal irritation analyses of the samples were performed and discussed. The use of cationic and anionic surfactants, namely, cetyltrimethylammonium bromide (CTAB) and sodium dodecyl sulfate (SDS), respectively, at a low concentration (2.5 mol%) modified the length/diameter (L/D) ratio of the HAp rods. Structural characterizations of hydroxyapatite synthesized without surfactant (HA), with 2.5 and 5 mol% of SDS (SDS− and SDS+, respectively), and with 2.5 and 5 mol% of CTAB (CTAB− and CTAB+, respectively) revealed well-crystallized samples in the hexagonal phase. The CTAB− sample presented antibacterial activity against <i>Pseudomonas aeruginosa</i>, <i>Escherichia coli</i>, <i>Streptococcus anginosus</i>, <i>Staphylococcus aureus</i>, <i>Micrococcus luteus</i>, and <i>Klebsiella pneumoniae</i>, suggesting that antimicrobial susceptibility was promoted by the bacterial nature and the use of the surfactant. Dermal irritation showed no clinical signs of disease in rabbits during the study, where there was neither erythema nor necrosis at the inoculation sites.Giovanni García DomínguezSebastián Diaz De La TorreLorena Chávez GüitrónErasto Vergara HernándezJoan Reyes MirandaMaribel Quezada CruzAristeo Garrido HernándezMDPI AGarticlehydroxyapatitenanorodsantibacterial activityhydrothermalsurfactantTechnologyTElectrical engineering. Electronics. Nuclear engineeringTK1-9971Engineering (General). Civil engineering (General)TA1-2040MicroscopyQH201-278.5Descriptive and experimental mechanicsQC120-168.85ENMaterials, Vol 14, Iss 6522, p 6522 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hydroxyapatite nanorods antibacterial activity hydrothermal surfactant Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
spellingShingle	hydroxyapatite nanorods antibacterial activity hydrothermal surfactant Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85 Giovanni García Domínguez Sebastián Diaz De La Torre Lorena Chávez Güitrón Erasto Vergara Hernández Joan Reyes Miranda Maribel Quezada Cruz Aristeo Garrido Hernández Effect of the Structural and Morphological Properties of Surfactant-Assisted Hydroxyapatite on Dermal Irritation and Antibacterial Activity
description	Hydroxyapatite (HAp) nanoparticles with a homogeneous rod morphology were successfully synthesized using the hydrothermal method. The powders were characterized using Fourier transform infrared spectroscopy, X-ray diffraction, and scanning electron microscopy. The antibacterial and dermal irritation analyses of the samples were performed and discussed. The use of cationic and anionic surfactants, namely, cetyltrimethylammonium bromide (CTAB) and sodium dodecyl sulfate (SDS), respectively, at a low concentration (2.5 mol%) modified the length/diameter (L/D) ratio of the HAp rods. Structural characterizations of hydroxyapatite synthesized without surfactant (HA), with 2.5 and 5 mol% of SDS (SDS− and SDS+, respectively), and with 2.5 and 5 mol% of CTAB (CTAB− and CTAB+, respectively) revealed well-crystallized samples in the hexagonal phase. The CTAB− sample presented antibacterial activity against <i>Pseudomonas aeruginosa</i>, <i>Escherichia coli</i>, <i>Streptococcus anginosus</i>, <i>Staphylococcus aureus</i>, <i>Micrococcus luteus</i>, and <i>Klebsiella pneumoniae</i>, suggesting that antimicrobial susceptibility was promoted by the bacterial nature and the use of the surfactant. Dermal irritation showed no clinical signs of disease in rabbits during the study, where there was neither erythema nor necrosis at the inoculation sites.
format	article
author	Giovanni García Domínguez Sebastián Diaz De La Torre Lorena Chávez Güitrón Erasto Vergara Hernández Joan Reyes Miranda Maribel Quezada Cruz Aristeo Garrido Hernández
author_facet	Giovanni García Domínguez Sebastián Diaz De La Torre Lorena Chávez Güitrón Erasto Vergara Hernández Joan Reyes Miranda Maribel Quezada Cruz Aristeo Garrido Hernández
author_sort	Giovanni García Domínguez
title	Effect of the Structural and Morphological Properties of Surfactant-Assisted Hydroxyapatite on Dermal Irritation and Antibacterial Activity
title_short	Effect of the Structural and Morphological Properties of Surfactant-Assisted Hydroxyapatite on Dermal Irritation and Antibacterial Activity
title_full	Effect of the Structural and Morphological Properties of Surfactant-Assisted Hydroxyapatite on Dermal Irritation and Antibacterial Activity
title_fullStr	Effect of the Structural and Morphological Properties of Surfactant-Assisted Hydroxyapatite on Dermal Irritation and Antibacterial Activity
title_full_unstemmed	Effect of the Structural and Morphological Properties of Surfactant-Assisted Hydroxyapatite on Dermal Irritation and Antibacterial Activity
title_sort	effect of the structural and morphological properties of surfactant-assisted hydroxyapatite on dermal irritation and antibacterial activity
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/98261b3b18324c8988b19ec741271267
work_keys_str_mv	AT giovannigarciadominguez effectofthestructuralandmorphologicalpropertiesofsurfactantassistedhydroxyapatiteondermalirritationandantibacterialactivity AT sebastiandiazdelatorre effectofthestructuralandmorphologicalpropertiesofsurfactantassistedhydroxyapatiteondermalirritationandantibacterialactivity AT lorenachavezguitron effectofthestructuralandmorphologicalpropertiesofsurfactantassistedhydroxyapatiteondermalirritationandantibacterialactivity AT erastovergarahernandez effectofthestructuralandmorphologicalpropertiesofsurfactantassistedhydroxyapatiteondermalirritationandantibacterialactivity AT joanreyesmiranda effectofthestructuralandmorphologicalpropertiesofsurfactantassistedhydroxyapatiteondermalirritationandantibacterialactivity AT maribelquezadacruz effectofthestructuralandmorphologicalpropertiesofsurfactantassistedhydroxyapatiteondermalirritationandantibacterialactivity AT aristeogarridohernandez effectofthestructuralandmorphologicalpropertiesofsurfactantassistedhydroxyapatiteondermalirritationandantibacterialactivity
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Effect of the Structural and Morphological Properties of Surfactant-Assisted Hydroxyapatite on Dermal Irritation and Antibacterial Activity

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