Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease

Heart contraction, which is decreased in disease, is determined by Ca2+binding to troponin C. Here, the authors combine a protein engineering approach with gene therapy to modulate heart contractility in mice with the use of rationally designed Troponin C variants, suggesting a new therapy for disea...

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Autores principales:	Vikram Shettigar, Bo Zhang, Sean C. Little, Hussam E. Salhi, Brian J. Hansen, Ning Li, Jianchao Zhang, Steve R. Roof, Hsiang-Ting Ho, Lucia Brunello, Jessica K. Lerch, Noah Weisleder, Vadim V. Fedorov, Federica Accornero, Jill A. Rafael-Fortney, Sandor Gyorke, Paul M. L. Janssen, Brandon J. Biesiadecki, Mark T. Ziolo, Jonathan P. Davis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9828c585327046c3b5306a0cb5e0d215
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spelling	oai:doaj.org-article:9828c585327046c3b5306a0cb5e0d2152021-12-02T17:32:21ZRationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease10.1038/ncomms107942041-1723https://doaj.org/article/9828c585327046c3b5306a0cb5e0d2152016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10794https://doaj.org/toc/2041-1723Heart contraction, which is decreased in disease, is determined by Ca2+binding to troponin C. Here, the authors combine a protein engineering approach with gene therapy to modulate heart contractility in mice with the use of rationally designed Troponin C variants, suggesting a new therapy for diseased hearts.Vikram ShettigarBo ZhangSean C. LittleHussam E. SalhiBrian J. HansenNing LiJianchao ZhangSteve R. RoofHsiang-Ting HoLucia BrunelloJessica K. LerchNoah WeislederVadim V. FedorovFederica AccorneroJill A. Rafael-FortneySandor GyorkePaul M. L. JanssenBrandon J. BiesiadeckiMark T. ZioloJonathan P. DavisNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vikram Shettigar Bo Zhang Sean C. Little Hussam E. Salhi Brian J. Hansen Ning Li Jianchao Zhang Steve R. Roof Hsiang-Ting Ho Lucia Brunello Jessica K. Lerch Noah Weisleder Vadim V. Fedorov Federica Accornero Jill A. Rafael-Fortney Sandor Gyorke Paul M. L. Janssen Brandon J. Biesiadecki Mark T. Ziolo Jonathan P. Davis Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease
description	Heart contraction, which is decreased in disease, is determined by Ca2+binding to troponin C. Here, the authors combine a protein engineering approach with gene therapy to modulate heart contractility in mice with the use of rationally designed Troponin C variants, suggesting a new therapy for diseased hearts.
format	article
author	Vikram Shettigar Bo Zhang Sean C. Little Hussam E. Salhi Brian J. Hansen Ning Li Jianchao Zhang Steve R. Roof Hsiang-Ting Ho Lucia Brunello Jessica K. Lerch Noah Weisleder Vadim V. Fedorov Federica Accornero Jill A. Rafael-Fortney Sandor Gyorke Paul M. L. Janssen Brandon J. Biesiadecki Mark T. Ziolo Jonathan P. Davis
author_facet	Vikram Shettigar Bo Zhang Sean C. Little Hussam E. Salhi Brian J. Hansen Ning Li Jianchao Zhang Steve R. Roof Hsiang-Ting Ho Lucia Brunello Jessica K. Lerch Noah Weisleder Vadim V. Fedorov Federica Accornero Jill A. Rafael-Fortney Sandor Gyorke Paul M. L. Janssen Brandon J. Biesiadecki Mark T. Ziolo Jonathan P. Davis
author_sort	Vikram Shettigar
title	Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease
title_short	Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease
title_full	Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease
title_fullStr	Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease
title_full_unstemmed	Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease
title_sort	rationally engineered troponin c modulates in vivo cardiac function and performance in health and disease
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/9828c585327046c3b5306a0cb5e0d215
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Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease

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