Time-lapse crystallography snapshots of a double-strand break repair polymerase in action

DNA polymerase (pol) μ functions in DNA double-strand break repair. Here the authors use time-lapse X-ray crystallography to capture the states of pol µ during the conversion from pre-catalytic to product complex and observe a third transiently bound metal ion in the product state.

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Autores principales:	Joonas A. Jamsen, William A. Beard, Lars C. Pedersen, David D. Shock, Andrea F. Moon, Juno M. Krahn, Katarzyna Bebenek, Thomas A. Kunkel, Samuel H. Wilson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/982a48bce8204f249e81938b26845c43
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spelling	oai:doaj.org-article:982a48bce8204f249e81938b26845c432021-12-02T13:57:32ZTime-lapse crystallography snapshots of a double-strand break repair polymerase in action10.1038/s41467-017-00271-72041-1723https://doaj.org/article/982a48bce8204f249e81938b26845c432017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00271-7https://doaj.org/toc/2041-1723DNA polymerase (pol) μ functions in DNA double-strand break repair. Here the authors use time-lapse X-ray crystallography to capture the states of pol µ during the conversion from pre-catalytic to product complex and observe a third transiently bound metal ion in the product state.Joonas A. JamsenWilliam A. BeardLars C. PedersenDavid D. ShockAndrea F. MoonJuno M. KrahnKatarzyna BebenekThomas A. KunkelSamuel H. WilsonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joonas A. Jamsen William A. Beard Lars C. Pedersen David D. Shock Andrea F. Moon Juno M. Krahn Katarzyna Bebenek Thomas A. Kunkel Samuel H. Wilson Time-lapse crystallography snapshots of a double-strand break repair polymerase in action
description	DNA polymerase (pol) μ functions in DNA double-strand break repair. Here the authors use time-lapse X-ray crystallography to capture the states of pol µ during the conversion from pre-catalytic to product complex and observe a third transiently bound metal ion in the product state.
format	article
author	Joonas A. Jamsen William A. Beard Lars C. Pedersen David D. Shock Andrea F. Moon Juno M. Krahn Katarzyna Bebenek Thomas A. Kunkel Samuel H. Wilson
author_facet	Joonas A. Jamsen William A. Beard Lars C. Pedersen David D. Shock Andrea F. Moon Juno M. Krahn Katarzyna Bebenek Thomas A. Kunkel Samuel H. Wilson
author_sort	Joonas A. Jamsen
title	Time-lapse crystallography snapshots of a double-strand break repair polymerase in action
title_short	Time-lapse crystallography snapshots of a double-strand break repair polymerase in action
title_full	Time-lapse crystallography snapshots of a double-strand break repair polymerase in action
title_fullStr	Time-lapse crystallography snapshots of a double-strand break repair polymerase in action
title_full_unstemmed	Time-lapse crystallography snapshots of a double-strand break repair polymerase in action
title_sort	time-lapse crystallography snapshots of a double-strand break repair polymerase in action
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/982a48bce8204f249e81938b26845c43
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Time-lapse crystallography snapshots of a double-strand break repair polymerase in action

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