One-pot synthesis of magnetic nanoclusters enabling atherosclerosis-targeted magnetic resonance imaging

Aastha Kukreja,1 Eun-Kyung Lim,2–4 Byunghoon Kang,1 Yuna Choi,2 Taeksu Lee,1 Jin-Suck Suh,2,3 Yong-Min Huh,2,3 Seungjoo Haam1,31Department of Chemical and Biomolecular Engineering, College of Engineering, 2Department of Radiology, College of Medicine, Yonsei University, Seoul, Republic of...

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Autores principales:	Kukreja A, Lim EK, Kang B, Choi Y, Lee T, Suh JS, Huh YM, Haam S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/982bb6237102489c92c34a105f5c8591
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spelling	oai:doaj.org-article:982bb6237102489c92c34a105f5c85912021-12-02T07:46:33ZOne-pot synthesis of magnetic nanoclusters enabling atherosclerosis-targeted magnetic resonance imaging1178-2013https://doaj.org/article/982bb6237102489c92c34a105f5c85912014-05-01T00:00:00Zhttp://www.dovepress.com/one-pot-synthesis-of-magnetic-nanoclusters-enabling-atherosclerosis-ta-a16921https://doaj.org/toc/1178-2013 Aastha Kukreja,1 Eun-Kyung Lim,2–4 Byunghoon Kang,1 Yuna Choi,2 Taeksu Lee,1 Jin-Suck Suh,2,3 Yong-Min Huh,2,3 Seungjoo Haam1,31Department of Chemical and Biomolecular Engineering, College of Engineering, 2Department of Radiology, College of Medicine, Yonsei University, Seoul, Republic of Korea; 3YUHS-KRIBB Medical Convergence Research Institute, Seoul, Republic of Korea; 4BioNanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of KoreaAbstract: In this study, dextran-encrusted magnetic nanoclusters (DMNCs) were synthesized using a one-pot solution phase method for detection of atherosclerosis by magnetic resonance imaging. Pyrenyl dextran was used as a surfactant because of its electron-stabilizing effect and its amphiphilic nature, rendering the DMNCs stable and water-dispersible. The DMNCs were 65.6±4.3 nm, had a narrow size distribution, and were superparamagnetic with a high magnetization value of 60.1 emu/g. Further, they showed biocompatibility and high cellular uptake efficiency, as indicated by a strong interaction between dextran and macrophages. In vivo magnetic resonance imaging demonstrated the ability of DMNCs to act as an efficient magnetic resonance imaging contrast agent capable of targeted detection of atherosclerosis. In view of these findings, it is concluded that DMNCs can be used as magnetic resonance imaging contrast agents to detect inflammatory disease.Keywords: magnetic nanocrystal, magnetic resonance imaging, atherosclerosis, macrophages, dextranKukreja ALim EKKang BChoi YLee TSuh JSHuh YMHaam SDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 2489-2498 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Kukreja A Lim EK Kang B Choi Y Lee T Suh JS Huh YM Haam S One-pot synthesis of magnetic nanoclusters enabling atherosclerosis-targeted magnetic resonance imaging
description	Aastha Kukreja,1 Eun-Kyung Lim,2–4 Byunghoon Kang,1 Yuna Choi,2 Taeksu Lee,1 Jin-Suck Suh,2,3 Yong-Min Huh,2,3 Seungjoo Haam1,31Department of Chemical and Biomolecular Engineering, College of Engineering, 2Department of Radiology, College of Medicine, Yonsei University, Seoul, Republic of Korea; 3YUHS-KRIBB Medical Convergence Research Institute, Seoul, Republic of Korea; 4BioNanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of KoreaAbstract: In this study, dextran-encrusted magnetic nanoclusters (DMNCs) were synthesized using a one-pot solution phase method for detection of atherosclerosis by magnetic resonance imaging. Pyrenyl dextran was used as a surfactant because of its electron-stabilizing effect and its amphiphilic nature, rendering the DMNCs stable and water-dispersible. The DMNCs were 65.6±4.3 nm, had a narrow size distribution, and were superparamagnetic with a high magnetization value of 60.1 emu/g. Further, they showed biocompatibility and high cellular uptake efficiency, as indicated by a strong interaction between dextran and macrophages. In vivo magnetic resonance imaging demonstrated the ability of DMNCs to act as an efficient magnetic resonance imaging contrast agent capable of targeted detection of atherosclerosis. In view of these findings, it is concluded that DMNCs can be used as magnetic resonance imaging contrast agents to detect inflammatory disease.Keywords: magnetic nanocrystal, magnetic resonance imaging, atherosclerosis, macrophages, dextran
format	article
author	Kukreja A Lim EK Kang B Choi Y Lee T Suh JS Huh YM Haam S
author_facet	Kukreja A Lim EK Kang B Choi Y Lee T Suh JS Huh YM Haam S
author_sort	Kukreja A
title	One-pot synthesis of magnetic nanoclusters enabling atherosclerosis-targeted magnetic resonance imaging
title_short	One-pot synthesis of magnetic nanoclusters enabling atherosclerosis-targeted magnetic resonance imaging
title_full	One-pot synthesis of magnetic nanoclusters enabling atherosclerosis-targeted magnetic resonance imaging
title_fullStr	One-pot synthesis of magnetic nanoclusters enabling atherosclerosis-targeted magnetic resonance imaging
title_full_unstemmed	One-pot synthesis of magnetic nanoclusters enabling atherosclerosis-targeted magnetic resonance imaging
title_sort	one-pot synthesis of magnetic nanoclusters enabling atherosclerosis-targeted magnetic resonance imaging
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/982bb6237102489c92c34a105f5c8591
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One-pot synthesis of magnetic nanoclusters enabling atherosclerosis-targeted magnetic resonance imaging

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