Comparison of 627 patients with right- and left-sided colon cancer in China: Differences in clinicopathology, recurrence, and survival

Comparison of 627 patients with right- and left-sided colon cancer in China: Differences in clinicopathology, recurrence, and survival

Objective: Recent studies have reported increased mortality for right-sided colon cancers; however, the results are conflicting for different stage tumors. We examined the differences in clinicopathology between right- and left-sided colon cancers and the relationships between colon cancer location...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Qiong Qin, Lin Yang, Yong-Kun Sun, Jian-Ming Ying, Yan Song, Wen Zhang, Jin-Wan Wang, Ai-Ping Zhou
Formato: article
Lenguaje:EN
Publicado: KeAi Communications Co., Ltd. 2017
Materias:
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/982f8063c64f443ea7229180d9533734
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:982f8063c64f443ea7229180d9533734
record_format dspace
spelling oai:doaj.org-article:982f8063c64f443ea7229180d95337342021-12-02T13:46:43ZComparison of 627 patients with right- and left-sided colon cancer in China: Differences in clinicopathology, recurrence, and survival2095-882X10.1016/j.cdtm.2017.02.004https://doaj.org/article/982f8063c64f443ea7229180d95337342017-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X16300986https://doaj.org/toc/2095-882XObjective: Recent studies have reported increased mortality for right-sided colon cancers; however, the results are conflicting for different stage tumors. We examined the differences in clinicopathology between right- and left-sided colon cancers and the relationships between colon cancer location (right- and left-side) and 5-year disease-free survival (DFS) and overall survival (OS). Methods: We identified patients from 2005 to 2008 with stage II/III colon cancer who underwent surgery for curative intent. We explored the impact of the tumor location on the postoperative DFS and OS using univariate and multivariate analyses. Results: Of 627 patients, 50.6% (317/627) had right-sided colon cancer. These patients were more likely to have weight loss, second primary tumor, elevated preoperative carbohydrate antigen 19-9 (CA19-9), increased incidence of non-adenocarcinoma, more poorly differentiated tumors, vascular invasion, defective mismatch repair, and a lighter smoking history (P < 0.05). Right-sided colon cancer had a higher recurrence incidence compared with left-sided cancer (30.6% vs. 23.2%, P = 0.037), particularly with multiple metastatic sites in the first recurrence (17.5% vs. 5.6%, P = 0.020). KaplanâMeier survival curves demonstrated a significant difference in the 5-year DFS rate between right- and left-sided cancers across all stages (68.1% vs. 75.2%, P = 0.043). However, there was no significant difference in the 5-year OS rate between the two groups (73.8% vs. 79.0%, P = 0.103). Subgroup analysis demonstrated that patients with left-sided colon cancer had a significantly better 5-year DFS and OS rates compared with those with right-sided disease at stage III (64.3% vs. 46.8%, P = 0.002; 69.5% vs. 53.5%, P = 0.006, respectively); there were no significant differences in the 5-year DFS and OS rates at stage II (85.2% vs. 85.9%, P = 0.819; 89.8% vs. 88.5%, P = 0.803, respectively). Adjusted Cox regression analysis showed no significant differences in the 5-year OS and DFS rates for stage II [hazard ratio (HR) = 1.203, 95% confidence interval (CI): 0.605â2.391, P = 0.598; HR = 0.980, 95% CI: 0.542â1.774, P = 0.948, respectively] or all stages combined (HR = 0.867, 95% CI: 0.613â1.227, P = 0.421; HR = 0.832, 95% CI: 0.606â1.142, P = 0.255, respectively). However, stage III left-sided cancer had higher 5-year OS and DFS rates (HR = 0.626, 95% CI: 0.414â0.948, P = 0.027; HR = 0.630, 95% CI: 0.428â0.926, P = 0.019, respectively). Conclusion: We found that right- and left-sided colon cancers had significantly different clinicopathological characteristics. Right-sided colon cancer had a higher incidence of recurrence than left-sided disease. Patients with stage III right-sided colon cancer had a worse prognosis compared with those with stage III left-sided colon cancer. Keywords: Colon cancer, Location, Recurrence, SurvivalQiong QinLin YangYong-Kun SunJian-Ming YingYan SongWen ZhangJin-Wan WangAi-Ping ZhouKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 3, Iss 1, Pp 51-59 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Qiong Qin
Lin Yang
Yong-Kun Sun
Jian-Ming Ying
Yan Song
Wen Zhang
Jin-Wan Wang
Ai-Ping Zhou
Comparison of 627 patients with right- and left-sided colon cancer in China: Differences in clinicopathology, recurrence, and survival
description Objective: Recent studies have reported increased mortality for right-sided colon cancers; however, the results are conflicting for different stage tumors. We examined the differences in clinicopathology between right- and left-sided colon cancers and the relationships between colon cancer location (right- and left-side) and 5-year disease-free survival (DFS) and overall survival (OS). Methods: We identified patients from 2005 to 2008 with stage II/III colon cancer who underwent surgery for curative intent. We explored the impact of the tumor location on the postoperative DFS and OS using univariate and multivariate analyses. Results: Of 627 patients, 50.6% (317/627) had right-sided colon cancer. These patients were more likely to have weight loss, second primary tumor, elevated preoperative carbohydrate antigen 19-9 (CA19-9), increased incidence of non-adenocarcinoma, more poorly differentiated tumors, vascular invasion, defective mismatch repair, and a lighter smoking history (P < 0.05). Right-sided colon cancer had a higher recurrence incidence compared with left-sided cancer (30.6% vs. 23.2%, P = 0.037), particularly with multiple metastatic sites in the first recurrence (17.5% vs. 5.6%, P = 0.020). KaplanâMeier survival curves demonstrated a significant difference in the 5-year DFS rate between right- and left-sided cancers across all stages (68.1% vs. 75.2%, P = 0.043). However, there was no significant difference in the 5-year OS rate between the two groups (73.8% vs. 79.0%, P = 0.103). Subgroup analysis demonstrated that patients with left-sided colon cancer had a significantly better 5-year DFS and OS rates compared with those with right-sided disease at stage III (64.3% vs. 46.8%, P = 0.002; 69.5% vs. 53.5%, P = 0.006, respectively); there were no significant differences in the 5-year DFS and OS rates at stage II (85.2% vs. 85.9%, P = 0.819; 89.8% vs. 88.5%, P = 0.803, respectively). Adjusted Cox regression analysis showed no significant differences in the 5-year OS and DFS rates for stage II [hazard ratio (HR) = 1.203, 95% confidence interval (CI): 0.605â2.391, P = 0.598; HR = 0.980, 95% CI: 0.542â1.774, P = 0.948, respectively] or all stages combined (HR = 0.867, 95% CI: 0.613â1.227, P = 0.421; HR = 0.832, 95% CI: 0.606â1.142, P = 0.255, respectively). However, stage III left-sided cancer had higher 5-year OS and DFS rates (HR = 0.626, 95% CI: 0.414â0.948, P = 0.027; HR = 0.630, 95% CI: 0.428â0.926, P = 0.019, respectively). Conclusion: We found that right- and left-sided colon cancers had significantly different clinicopathological characteristics. Right-sided colon cancer had a higher incidence of recurrence than left-sided disease. Patients with stage III right-sided colon cancer had a worse prognosis compared with those with stage III left-sided colon cancer. Keywords: Colon cancer, Location, Recurrence, Survival
format article
author Qiong Qin
Lin Yang
Yong-Kun Sun
Jian-Ming Ying
Yan Song
Wen Zhang
Jin-Wan Wang
Ai-Ping Zhou
author_facet Qiong Qin
Lin Yang
Yong-Kun Sun
Jian-Ming Ying
Yan Song
Wen Zhang
Jin-Wan Wang
Ai-Ping Zhou
author_sort Qiong Qin
title Comparison of 627 patients with right- and left-sided colon cancer in China: Differences in clinicopathology, recurrence, and survival
title_short Comparison of 627 patients with right- and left-sided colon cancer in China: Differences in clinicopathology, recurrence, and survival
title_full Comparison of 627 patients with right- and left-sided colon cancer in China: Differences in clinicopathology, recurrence, and survival
title_fullStr Comparison of 627 patients with right- and left-sided colon cancer in China: Differences in clinicopathology, recurrence, and survival
title_full_unstemmed Comparison of 627 patients with right- and left-sided colon cancer in China: Differences in clinicopathology, recurrence, and survival
title_sort comparison of 627 patients with right- and left-sided colon cancer in china: differences in clinicopathology, recurrence, and survival
publisher KeAi Communications Co., Ltd.
publishDate 2017
url https://doaj.org/article/982f8063c64f443ea7229180d9533734
work_keys_str_mv AT qiongqin comparisonof627patientswithrightandleftsidedcoloncancerinchinadifferencesinclinicopathologyrecurrenceandsurvival
AT linyang comparisonof627patientswithrightandleftsidedcoloncancerinchinadifferencesinclinicopathologyrecurrenceandsurvival
AT yongkunsun comparisonof627patientswithrightandleftsidedcoloncancerinchinadifferencesinclinicopathologyrecurrenceandsurvival
AT jianmingying comparisonof627patientswithrightandleftsidedcoloncancerinchinadifferencesinclinicopathologyrecurrenceandsurvival
AT yansong comparisonof627patientswithrightandleftsidedcoloncancerinchinadifferencesinclinicopathologyrecurrenceandsurvival
AT wenzhang comparisonof627patientswithrightandleftsidedcoloncancerinchinadifferencesinclinicopathologyrecurrenceandsurvival
AT jinwanwang comparisonof627patientswithrightandleftsidedcoloncancerinchinadifferencesinclinicopathologyrecurrenceandsurvival
AT aipingzhou comparisonof627patientswithrightandleftsidedcoloncancerinchinadifferencesinclinicopathologyrecurrenceandsurvival
_version_ 1718392510606213120

Ejemplares similares