Characterization of Individualized Glycemic Excursions during a Standardized Bout of Hypoglycemia-Inducing Exercise and Subsequent Hypoglycemia Treatment—A Pilot Study

The glycemic response to ingested glucose for the treatment of hypoglycemia following exercise in type 1 diabetes patients has never been studied. Therefore, we aimed to characterize glucose dynamics during a standardized bout of hypoglycemia-inducing exercise and the subsequent hypoglycemia treatme...

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Autores principales:	Jan Brož, Matthew D. Campbell, Jana Urbanová, Marisa A. Nunes, Ludmila Brunerová, Dario Rahelić, Denisa Janíčková Žďárská, Arian Taniwall, Marek Brabec, Vojtěch Berka, Juraj Michalec, Jan Polák
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	type 1 diabetes exercise hypoglycemia insulin therapy glycemic excursion hypoglycemia treatment Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/982f9757b1bb41d3834cde83761ebc84
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spelling	oai:doaj.org-article:982f9757b1bb41d3834cde83761ebc842021-11-25T18:37:16ZCharacterization of Individualized Glycemic Excursions during a Standardized Bout of Hypoglycemia-Inducing Exercise and Subsequent Hypoglycemia Treatment—A Pilot Study10.3390/nu131141652072-6643https://doaj.org/article/982f9757b1bb41d3834cde83761ebc842021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4165https://doaj.org/toc/2072-6643The glycemic response to ingested glucose for the treatment of hypoglycemia following exercise in type 1 diabetes patients has never been studied. Therefore, we aimed to characterize glucose dynamics during a standardized bout of hypoglycemia-inducing exercise and the subsequent hypoglycemia treatment with the oral ingestion of glucose. Ten male patients with type 1 diabetes performed a standardized bout of cycling exercise using an electrically braked ergometer at a target heart rate (THR) of 50% of the individual heart rate reserve, determined using the Karvonen equation. Exercise was terminated when hypoglycemia was reached, followed by immediate hypoglycemia treatment with the oral ingestion of 20 g of glucose. Arterialized blood glucose (ABG) levels were monitored at 5 min intervals during exercise and for 60 min during recovery. During exercise, ABG decreased at a mean rate of 0.11 ± 0.03 mmol/L·min<sup>−1</sup> (minimum: 0.07, maximum: 0.17 mmol/L·min<sup>−1</sup>). During recovery, ABG increased at a mean rate of 0.13 ± 0.05 mmol/L·min<sup>−1</sup> (minimum: 0.06, maximum: 0.19 mmol/L·min<sup>−1</sup>). Moreover, 20 g of glucose maintained recovery from hypoglycemia throughout the 60 min postexercise observation window.Jan BrožMatthew D. CampbellJana UrbanováMarisa A. NunesLudmila BrunerováDario RahelićDenisa Janíčková ŽďárskáArian TaniwallMarek BrabecVojtěch BerkaJuraj MichalecJan PolákMDPI AGarticletype 1 diabetesexercisehypoglycemiainsulin therapyglycemic excursionhypoglycemia treatmentNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4165, p 4165 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	type 1 diabetes exercise hypoglycemia insulin therapy glycemic excursion hypoglycemia treatment Nutrition. Foods and food supply TX341-641
spellingShingle	type 1 diabetes exercise hypoglycemia insulin therapy glycemic excursion hypoglycemia treatment Nutrition. Foods and food supply TX341-641 Jan Brož Matthew D. Campbell Jana Urbanová Marisa A. Nunes Ludmila Brunerová Dario Rahelić Denisa Janíčková Žďárská Arian Taniwall Marek Brabec Vojtěch Berka Juraj Michalec Jan Polák Characterization of Individualized Glycemic Excursions during a Standardized Bout of Hypoglycemia-Inducing Exercise and Subsequent Hypoglycemia Treatment—A Pilot Study
description	The glycemic response to ingested glucose for the treatment of hypoglycemia following exercise in type 1 diabetes patients has never been studied. Therefore, we aimed to characterize glucose dynamics during a standardized bout of hypoglycemia-inducing exercise and the subsequent hypoglycemia treatment with the oral ingestion of glucose. Ten male patients with type 1 diabetes performed a standardized bout of cycling exercise using an electrically braked ergometer at a target heart rate (THR) of 50% of the individual heart rate reserve, determined using the Karvonen equation. Exercise was terminated when hypoglycemia was reached, followed by immediate hypoglycemia treatment with the oral ingestion of 20 g of glucose. Arterialized blood glucose (ABG) levels were monitored at 5 min intervals during exercise and for 60 min during recovery. During exercise, ABG decreased at a mean rate of 0.11 ± 0.03 mmol/L·min<sup>−1</sup> (minimum: 0.07, maximum: 0.17 mmol/L·min<sup>−1</sup>). During recovery, ABG increased at a mean rate of 0.13 ± 0.05 mmol/L·min<sup>−1</sup> (minimum: 0.06, maximum: 0.19 mmol/L·min<sup>−1</sup>). Moreover, 20 g of glucose maintained recovery from hypoglycemia throughout the 60 min postexercise observation window.
format	article
author	Jan Brož Matthew D. Campbell Jana Urbanová Marisa A. Nunes Ludmila Brunerová Dario Rahelić Denisa Janíčková Žďárská Arian Taniwall Marek Brabec Vojtěch Berka Juraj Michalec Jan Polák
author_facet	Jan Brož Matthew D. Campbell Jana Urbanová Marisa A. Nunes Ludmila Brunerová Dario Rahelić Denisa Janíčková Žďárská Arian Taniwall Marek Brabec Vojtěch Berka Juraj Michalec Jan Polák
author_sort	Jan Brož
title	Characterization of Individualized Glycemic Excursions during a Standardized Bout of Hypoglycemia-Inducing Exercise and Subsequent Hypoglycemia Treatment—A Pilot Study
title_short	Characterization of Individualized Glycemic Excursions during a Standardized Bout of Hypoglycemia-Inducing Exercise and Subsequent Hypoglycemia Treatment—A Pilot Study
title_full	Characterization of Individualized Glycemic Excursions during a Standardized Bout of Hypoglycemia-Inducing Exercise and Subsequent Hypoglycemia Treatment—A Pilot Study
title_fullStr	Characterization of Individualized Glycemic Excursions during a Standardized Bout of Hypoglycemia-Inducing Exercise and Subsequent Hypoglycemia Treatment—A Pilot Study
title_full_unstemmed	Characterization of Individualized Glycemic Excursions during a Standardized Bout of Hypoglycemia-Inducing Exercise and Subsequent Hypoglycemia Treatment—A Pilot Study
title_sort	characterization of individualized glycemic excursions during a standardized bout of hypoglycemia-inducing exercise and subsequent hypoglycemia treatment—a pilot study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/982f9757b1bb41d3834cde83761ebc84
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Characterization of Individualized Glycemic Excursions during a Standardized Bout of Hypoglycemia-Inducing Exercise and Subsequent Hypoglycemia Treatment—A Pilot Study

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