Neuroprotective effects of the new Na channel blocker rs100642 in global ischemic brain injury

Introduction RS100642, a mexiletine analogue, is a novel sodium channel blocker with neuroprotective and antioxidant activities. The protectivity of RS100642, which has been shown against focal cerebral ischemia, was investigated in global cerebral ischemia in this study. Material and methods Globa...

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Autores principales:	Suat Kamisli, Cenk Basaran, Kadir Batcioglu, Mustafa Namık Oztanir, Mehmet Gul, Basri Satilmis, Ayse Burcin Uyumlu, Basak Kayhan, Metin Genc
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2019
Materias:	brain injury neuroprotection global cerebral ischemia sodium channels Medicine R
Acceso en línea:	https://doaj.org/article/982fd01b4dc44f8691c5ad95b59e2f08
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spelling	oai:doaj.org-article:982fd01b4dc44f8691c5ad95b59e2f082021-12-02T16:59:26ZNeuroprotective effects of the new Na channel blocker rs100642 in global ischemic brain injury1734-19221896-915110.5114/aoms.2017.72550https://doaj.org/article/982fd01b4dc44f8691c5ad95b59e2f082019-03-01T00:00:00Zhttps://www.archivesofmedicalscience.com/Neuroprotective-effects-of-the-new-Na-channel-blocker-rs100642-in-global-ischemic,70491,0,2.htmlhttps://doaj.org/toc/1734-1922https://doaj.org/toc/1896-9151Introduction RS100642, a mexiletine analogue, is a novel sodium channel blocker with neuroprotective and antioxidant activities. The protectivity of RS100642, which has been shown against focal cerebral ischemia, was investigated in global cerebral ischemia in this study. Material and methods Global cerebral ischemia was induced for five minutes in adult male Wistar Albino rats via the 4-vessel occlusion method. Intravenous administration of 1 mg/kg RS100642 following reperfusion for 30 min (RS100642 group) was compared with a sham treatment group (ischemia group) and nonischemized group (control) histologically based on morphology and caspase-3 immunohistochemistry, and biochemically based both on measurement of oxidative stress including malondialdehyde (MDA) levels, superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) activities and on assessment of apoptosis including caspase-3 and -8 activities and tumor necrosis factor α (TNF-α) levels at the end of 6 h. Results While the RS100642 group had significantly lower MDA levels and higher SOD activities than the sham treatment group (p 0.05) and significantly lower than those of the controls (p < 0.05). Necrosis and caspase-3 activity and immunoreactivity in the RS100642 group were significantly lower than those in the sham treatment group (p 0.05). Conclusions Na + channel blockade by RS100642 has remarkable neuroprotective effects following global brain ischemia/reperfusion damage. Further research is required to determine the optimum dose and time of administration.Suat KamisliCenk BasaranKadir BatciogluMustafa Namık OztanirMehmet GulBasri SatilmisAyse Burcin UyumluBasak KayhanMetin GencTermedia Publishing Housearticlebrain injuryneuroprotectionglobal cerebral ischemiasodium channelsMedicineRENArchives of Medical Science, Vol 15, Iss 2, Pp 467-474 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	brain injury neuroprotection global cerebral ischemia sodium channels Medicine R
spellingShingle	brain injury neuroprotection global cerebral ischemia sodium channels Medicine R Suat Kamisli Cenk Basaran Kadir Batcioglu Mustafa Namık Oztanir Mehmet Gul Basri Satilmis Ayse Burcin Uyumlu Basak Kayhan Metin Genc Neuroprotective effects of the new Na channel blocker rs100642 in global ischemic brain injury
description	Introduction RS100642, a mexiletine analogue, is a novel sodium channel blocker with neuroprotective and antioxidant activities. The protectivity of RS100642, which has been shown against focal cerebral ischemia, was investigated in global cerebral ischemia in this study. Material and methods Global cerebral ischemia was induced for five minutes in adult male Wistar Albino rats via the 4-vessel occlusion method. Intravenous administration of 1 mg/kg RS100642 following reperfusion for 30 min (RS100642 group) was compared with a sham treatment group (ischemia group) and nonischemized group (control) histologically based on morphology and caspase-3 immunohistochemistry, and biochemically based both on measurement of oxidative stress including malondialdehyde (MDA) levels, superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) activities and on assessment of apoptosis including caspase-3 and -8 activities and tumor necrosis factor α (TNF-α) levels at the end of 6 h. Results While the RS100642 group had significantly lower MDA levels and higher SOD activities than the sham treatment group (p 0.05) and significantly lower than those of the controls (p < 0.05). Necrosis and caspase-3 activity and immunoreactivity in the RS100642 group were significantly lower than those in the sham treatment group (p 0.05). Conclusions Na + channel blockade by RS100642 has remarkable neuroprotective effects following global brain ischemia/reperfusion damage. Further research is required to determine the optimum dose and time of administration.
format	article
author	Suat Kamisli Cenk Basaran Kadir Batcioglu Mustafa Namık Oztanir Mehmet Gul Basri Satilmis Ayse Burcin Uyumlu Basak Kayhan Metin Genc
author_facet	Suat Kamisli Cenk Basaran Kadir Batcioglu Mustafa Namık Oztanir Mehmet Gul Basri Satilmis Ayse Burcin Uyumlu Basak Kayhan Metin Genc
author_sort	Suat Kamisli
title	Neuroprotective effects of the new Na channel blocker rs100642 in global ischemic brain injury
title_short	Neuroprotective effects of the new Na channel blocker rs100642 in global ischemic brain injury
title_full	Neuroprotective effects of the new Na channel blocker rs100642 in global ischemic brain injury
title_fullStr	Neuroprotective effects of the new Na channel blocker rs100642 in global ischemic brain injury
title_full_unstemmed	Neuroprotective effects of the new Na channel blocker rs100642 in global ischemic brain injury
title_sort	neuroprotective effects of the new na channel blocker rs100642 in global ischemic brain injury
publisher	Termedia Publishing House
publishDate	2019
url	https://doaj.org/article/982fd01b4dc44f8691c5ad95b59e2f08
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Neuroprotective effects of the new Na channel blocker rs100642 in global ischemic brain injury

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