Dietary micronutrients intake and plasma fibrinogen levels in the general adult population

Abstract Plasma fibrinogen predicts cardiovascular and nonvascular mortality. However, there is limited population-based evidence on the association between fibrinogen levels and dietary intakes of micronutrients possibly associated with inflammation status. Data were taken from the ENRICA study, co...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Alicia Padron-Monedero, Fernando Rodríguez-Artalejo, Esther Lopez-Garcia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/98326a66725243c29ca97b5e2888f980
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:98326a66725243c29ca97b5e2888f980
record_format	dspace
spelling	oai:doaj.org-article:98326a66725243c29ca97b5e2888f9802021-12-02T14:03:59ZDietary micronutrients intake and plasma fibrinogen levels in the general adult population10.1038/s41598-021-83217-w2045-2322https://doaj.org/article/98326a66725243c29ca97b5e2888f9802021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83217-whttps://doaj.org/toc/2045-2322Abstract Plasma fibrinogen predicts cardiovascular and nonvascular mortality. However, there is limited population-based evidence on the association between fibrinogen levels and dietary intakes of micronutrients possibly associated with inflammation status. Data were taken from the ENRICA study, conducted with 10,808 individuals representative of the population of Spain aged ≥ 18 years. Nutrient intake (vitamin A, carotenoids, vitamin B6, vitamin C, vitamin D, vitamin E, magnesium, selenium, zinc and iron) was estimated with a validated diet history, and plasma fibrinogen was measured under appropriate quality checks. Statistical analyses were performed with linear regression and adjusted for main confounders. The geometric means of fibrinogen (g/L) across increasing quintiles of nutrient intake were 3.22, 3.22, 3.22, 3.16, and 3.19 (p-trend = 0.030) for vitamin E; 3.23, 3.22, 3.20, 3.19, and 3.19 (p-trend = 0.047) for magnesium; and 3.24, 3.22, 3.19, 3.21, and 3.19 (p-trend = 0.050) for iron. These inverse associations were more marked in participants with abdominal obesity and aged ≥ 60 years, but lost statistical significance after adjustment for other nutrients. Although dietary intakes of vitamin E, magnesium and iron were inversely associated with fibrinogen levels, clinical implications of these findings are uncertain since these results were of very small magnitude and mostly explained by intake levels of other nutrients.Alicia Padron-MonederoFernando Rodríguez-ArtalejoEsther Lopez-GarciaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alicia Padron-Monedero Fernando Rodríguez-Artalejo Esther Lopez-Garcia Dietary micronutrients intake and plasma fibrinogen levels in the general adult population
description	Abstract Plasma fibrinogen predicts cardiovascular and nonvascular mortality. However, there is limited population-based evidence on the association between fibrinogen levels and dietary intakes of micronutrients possibly associated with inflammation status. Data were taken from the ENRICA study, conducted with 10,808 individuals representative of the population of Spain aged ≥ 18 years. Nutrient intake (vitamin A, carotenoids, vitamin B6, vitamin C, vitamin D, vitamin E, magnesium, selenium, zinc and iron) was estimated with a validated diet history, and plasma fibrinogen was measured under appropriate quality checks. Statistical analyses were performed with linear regression and adjusted for main confounders. The geometric means of fibrinogen (g/L) across increasing quintiles of nutrient intake were 3.22, 3.22, 3.22, 3.16, and 3.19 (p-trend = 0.030) for vitamin E; 3.23, 3.22, 3.20, 3.19, and 3.19 (p-trend = 0.047) for magnesium; and 3.24, 3.22, 3.19, 3.21, and 3.19 (p-trend = 0.050) for iron. These inverse associations were more marked in participants with abdominal obesity and aged ≥ 60 years, but lost statistical significance after adjustment for other nutrients. Although dietary intakes of vitamin E, magnesium and iron were inversely associated with fibrinogen levels, clinical implications of these findings are uncertain since these results were of very small magnitude and mostly explained by intake levels of other nutrients.
format	article
author	Alicia Padron-Monedero Fernando Rodríguez-Artalejo Esther Lopez-Garcia
author_facet	Alicia Padron-Monedero Fernando Rodríguez-Artalejo Esther Lopez-Garcia
author_sort	Alicia Padron-Monedero
title	Dietary micronutrients intake and plasma fibrinogen levels in the general adult population
title_short	Dietary micronutrients intake and plasma fibrinogen levels in the general adult population
title_full	Dietary micronutrients intake and plasma fibrinogen levels in the general adult population
title_fullStr	Dietary micronutrients intake and plasma fibrinogen levels in the general adult population
title_full_unstemmed	Dietary micronutrients intake and plasma fibrinogen levels in the general adult population
title_sort	dietary micronutrients intake and plasma fibrinogen levels in the general adult population
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/98326a66725243c29ca97b5e2888f980
work_keys_str_mv	AT aliciapadronmonedero dietarymicronutrientsintakeandplasmafibrinogenlevelsinthegeneraladultpopulation AT fernandorodriguezartalejo dietarymicronutrientsintakeandplasmafibrinogenlevelsinthegeneraladultpopulation AT estherlopezgarcia dietarymicronutrientsintakeandplasmafibrinogenlevelsinthegeneraladultpopulation
_version_	1718392036417077248

Dietary micronutrients intake and plasma fibrinogen levels in the general adult population

Ejemplares similares