Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity

Abnormal levels of Aβ42 in the cerebrospinal fluid occur prior to a positive amyloid PET scan in the brain of individuals with Alzheimer’s disease and here the authors use this temporal pattern to identify individuals with very early stage AD. They show that Aβ fibrils start to accumulate in some of...

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Autores principales:	Sebastian Palmqvist, Michael Schöll, Olof Strandberg, Niklas Mattsson, Erik Stomrud, Henrik Zetterberg, Kaj Blennow, Susan Landau, William Jagust, Oskar Hansson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9832f21d253e45ed88430bd1eb8d43d4
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spelling	oai:doaj.org-article:9832f21d253e45ed88430bd1eb8d43d42021-12-02T15:39:00ZEarliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity10.1038/s41467-017-01150-x2041-1723https://doaj.org/article/9832f21d253e45ed88430bd1eb8d43d42017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01150-xhttps://doaj.org/toc/2041-1723Abnormal levels of Aβ42 in the cerebrospinal fluid occur prior to a positive amyloid PET scan in the brain of individuals with Alzheimer’s disease and here the authors use this temporal pattern to identify individuals with very early stage AD. They show that Aβ fibrils start to accumulate in some of the regions of the default mode network and affect brain connectivity before neurodegeneration occurs.Sebastian PalmqvistMichael SchöllOlof StrandbergNiklas MattssonErik StomrudHenrik ZetterbergKaj BlennowSusan LandauWilliam JagustOskar HanssonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sebastian Palmqvist Michael Schöll Olof Strandberg Niklas Mattsson Erik Stomrud Henrik Zetterberg Kaj Blennow Susan Landau William Jagust Oskar Hansson Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity
description	Abnormal levels of Aβ42 in the cerebrospinal fluid occur prior to a positive amyloid PET scan in the brain of individuals with Alzheimer’s disease and here the authors use this temporal pattern to identify individuals with very early stage AD. They show that Aβ fibrils start to accumulate in some of the regions of the default mode network and affect brain connectivity before neurodegeneration occurs.
format	article
author	Sebastian Palmqvist Michael Schöll Olof Strandberg Niklas Mattsson Erik Stomrud Henrik Zetterberg Kaj Blennow Susan Landau William Jagust Oskar Hansson
author_facet	Sebastian Palmqvist Michael Schöll Olof Strandberg Niklas Mattsson Erik Stomrud Henrik Zetterberg Kaj Blennow Susan Landau William Jagust Oskar Hansson
author_sort	Sebastian Palmqvist
title	Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity
title_short	Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity
title_full	Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity
title_fullStr	Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity
title_full_unstemmed	Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity
title_sort	earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9832f21d253e45ed88430bd1eb8d43d4
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Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity

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