Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity

Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity

Abnormal levels of Aβ42 in the cerebrospinal fluid occur prior to a positive amyloid PET scan in the brain of individuals with Alzheimer’s disease and here the authors use this temporal pattern to identify individuals with very early stage AD. They show that Aβ fibrils start to accumulate in some of...

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Autores principales: Sebastian Palmqvist, Michael Schöll, Olof Strandberg, Niklas Mattsson, Erik Stomrud, Henrik Zetterberg, Kaj Blennow, Susan Landau, William Jagust, Oskar Hansson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/9832f21d253e45ed88430bd1eb8d43d4
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