Retinal reperfusion in diabetic retinopathy following treatment with anti-VEGF intravitreal injections

Ariana M Levin, Irene Rusu, Anton Orlin, Mrinali P Gupta, Peter Coombs, Donald J D’Amico, Szilárd Kiss Department of Ophthalmology, Weill Cornell Medical College, New York, NY, USA Purpose: The aim of this study is to report peripheral reperfusion of ischemic areas of the reti...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Levin AM, Rusu I, Orlin A, Gupta MP, Coombs P, D'Amico DJ, Kiss S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	anti-VEGF diabetes diabetic retinopathy ischemia perfusion reperfusion Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/9836855a8b7e430c965d41be6149fd53
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9836855a8b7e430c965d41be6149fd53
record_format	dspace
spelling	oai:doaj.org-article:9836855a8b7e430c965d41be6149fd532021-12-02T03:45:32ZRetinal reperfusion in diabetic retinopathy following treatment with anti-VEGF intravitreal injections1177-5483https://doaj.org/article/9836855a8b7e430c965d41be6149fd532017-01-01T00:00:00Zhttps://www.dovepress.com/retinal--reperfusion-in-diabetic-retinopathy-following-treatment-with--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Ariana M Levin, Irene Rusu, Anton Orlin, Mrinali P Gupta, Peter Coombs, Donald J D’Amico, Szilárd Kiss Department of Ophthalmology, Weill Cornell Medical College, New York, NY, USA Purpose: The aim of this study is to report peripheral reperfusion of ischemic areas of the retina on ultra-widefield fluorescein angiography (UWFA) following anti-vascular endothelial growth factor (VEGF) intravitreal injections in patients treated for diabetic retinopathy. Methods: This study is a retrospective review of 16 eyes of 15 patients with diabetic retinopathy, who received anti-VEGF intravitreal injections and underwent pre- and postinjection UWFA. The main outcome measured was the presence of reperfusion in postinjection UWFA images in areas of the retina that demonstrated nonperfusion in preinjection images. Images were analyzed for reperfusion qualitatively and quantitatively by two graders. Results: Twelve of 16 eyes (75%) or 11 of 15 patients (73.3%) demonstrated reperfusion following anti-VEGF injection. On UWFA, reperfusion was detected both within the field of 7-standard field (7SF) fluorescein angiography and in the periphery outside the 7SF. Four of 16 eyes or 4 of 15 patients did not demonstrate reperfusion, one of which had extensive scarring from prior panretinal photocoagulation. Conclusion: In patients with diabetic retinopathy, treatment with anti-VEGF agents can be associated with reperfusion of areas of nonperfusion, as demonstrated by UWFA. Keywords: anti-VEGF, diabetes, diabetic retinopathy, ischemia, perfusion, reperfusionLevin AMRusu IOrlin AGupta MPCoombs PD'Amico DJKiss SDove Medical Pressarticleanti-VEGFdiabetesdiabetic retinopathyischemiaperfusionreperfusionOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 11, Pp 193-200 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	anti-VEGF diabetes diabetic retinopathy ischemia perfusion reperfusion Ophthalmology RE1-994
spellingShingle	anti-VEGF diabetes diabetic retinopathy ischemia perfusion reperfusion Ophthalmology RE1-994 Levin AM Rusu I Orlin A Gupta MP Coombs P D'Amico DJ Kiss S Retinal reperfusion in diabetic retinopathy following treatment with anti-VEGF intravitreal injections
description	Ariana M Levin, Irene Rusu, Anton Orlin, Mrinali P Gupta, Peter Coombs, Donald J D’Amico, Szilárd Kiss Department of Ophthalmology, Weill Cornell Medical College, New York, NY, USA Purpose: The aim of this study is to report peripheral reperfusion of ischemic areas of the retina on ultra-widefield fluorescein angiography (UWFA) following anti-vascular endothelial growth factor (VEGF) intravitreal injections in patients treated for diabetic retinopathy. Methods: This study is a retrospective review of 16 eyes of 15 patients with diabetic retinopathy, who received anti-VEGF intravitreal injections and underwent pre- and postinjection UWFA. The main outcome measured was the presence of reperfusion in postinjection UWFA images in areas of the retina that demonstrated nonperfusion in preinjection images. Images were analyzed for reperfusion qualitatively and quantitatively by two graders. Results: Twelve of 16 eyes (75%) or 11 of 15 patients (73.3%) demonstrated reperfusion following anti-VEGF injection. On UWFA, reperfusion was detected both within the field of 7-standard field (7SF) fluorescein angiography and in the periphery outside the 7SF. Four of 16 eyes or 4 of 15 patients did not demonstrate reperfusion, one of which had extensive scarring from prior panretinal photocoagulation. Conclusion: In patients with diabetic retinopathy, treatment with anti-VEGF agents can be associated with reperfusion of areas of nonperfusion, as demonstrated by UWFA. Keywords: anti-VEGF, diabetes, diabetic retinopathy, ischemia, perfusion, reperfusion
format	article
author	Levin AM Rusu I Orlin A Gupta MP Coombs P D'Amico DJ Kiss S
author_facet	Levin AM Rusu I Orlin A Gupta MP Coombs P D'Amico DJ Kiss S
author_sort	Levin AM
title	Retinal reperfusion in diabetic retinopathy following treatment with anti-VEGF intravitreal injections
title_short	Retinal reperfusion in diabetic retinopathy following treatment with anti-VEGF intravitreal injections
title_full	Retinal reperfusion in diabetic retinopathy following treatment with anti-VEGF intravitreal injections
title_fullStr	Retinal reperfusion in diabetic retinopathy following treatment with anti-VEGF intravitreal injections
title_full_unstemmed	Retinal reperfusion in diabetic retinopathy following treatment with anti-VEGF intravitreal injections
title_sort	retinal reperfusion in diabetic retinopathy following treatment with anti-vegf intravitreal injections
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/9836855a8b7e430c965d41be6149fd53
work_keys_str_mv	AT levinam retinalreperfusionindiabeticretinopathyfollowingtreatmentwithantivegfintravitrealinjections AT rusui retinalreperfusionindiabeticretinopathyfollowingtreatmentwithantivegfintravitrealinjections AT orlina retinalreperfusionindiabeticretinopathyfollowingtreatmentwithantivegfintravitrealinjections AT guptamp retinalreperfusionindiabeticretinopathyfollowingtreatmentwithantivegfintravitrealinjections AT coombsp retinalreperfusionindiabeticretinopathyfollowingtreatmentwithantivegfintravitrealinjections AT damicodj retinalreperfusionindiabeticretinopathyfollowingtreatmentwithantivegfintravitrealinjections AT kisss retinalreperfusionindiabeticretinopathyfollowingtreatmentwithantivegfintravitrealinjections
_version_	1718401639455391744

Retinal reperfusion in diabetic retinopathy following treatment with anti-VEGF intravitreal injections

Ejemplares similares