Preventing and treating PTSD-like memory by trauma contextualization

Individuals with PTSD are unable to recollect contextual cues related to the trauma. Here the authors show that this contextual amnesia, associated with the inhibition of hippocampal activity, is causally involved in PTSD-like hypermnesia in mice, and that re-exposure to all trauma-related cues elim...

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Autores principales:	Alice Shaam Al Abed, Eva-Gunnel Ducourneau, Chloé Bouarab, Azza Sellami, Aline Marighetto, Aline Desmedt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9837c4635cbe4367969ea714515e0a56
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spelling	oai:doaj.org-article:9837c4635cbe4367969ea714515e0a562021-12-02T18:53:20ZPreventing and treating PTSD-like memory by trauma contextualization10.1038/s41467-020-18002-w2041-1723https://doaj.org/article/9837c4635cbe4367969ea714515e0a562020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18002-whttps://doaj.org/toc/2041-1723Individuals with PTSD are unable to recollect contextual cues related to the trauma. Here the authors show that this contextual amnesia, associated with the inhibition of hippocampal activity, is causally involved in PTSD-like hypermnesia in mice, and that re-exposure to all trauma-related cues eliminates PTSD-like memory while promoting normal fear memory.Alice Shaam Al AbedEva-Gunnel DucourneauChloé BouarabAzza SellamiAline MarighettoAline DesmedtNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alice Shaam Al Abed Eva-Gunnel Ducourneau Chloé Bouarab Azza Sellami Aline Marighetto Aline Desmedt Preventing and treating PTSD-like memory by trauma contextualization
description	Individuals with PTSD are unable to recollect contextual cues related to the trauma. Here the authors show that this contextual amnesia, associated with the inhibition of hippocampal activity, is causally involved in PTSD-like hypermnesia in mice, and that re-exposure to all trauma-related cues eliminates PTSD-like memory while promoting normal fear memory.
format	article
author	Alice Shaam Al Abed Eva-Gunnel Ducourneau Chloé Bouarab Azza Sellami Aline Marighetto Aline Desmedt
author_facet	Alice Shaam Al Abed Eva-Gunnel Ducourneau Chloé Bouarab Azza Sellami Aline Marighetto Aline Desmedt
author_sort	Alice Shaam Al Abed
title	Preventing and treating PTSD-like memory by trauma contextualization
title_short	Preventing and treating PTSD-like memory by trauma contextualization
title_full	Preventing and treating PTSD-like memory by trauma contextualization
title_fullStr	Preventing and treating PTSD-like memory by trauma contextualization
title_full_unstemmed	Preventing and treating PTSD-like memory by trauma contextualization
title_sort	preventing and treating ptsd-like memory by trauma contextualization
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9837c4635cbe4367969ea714515e0a56
work_keys_str_mv	AT aliceshaamalabed preventingandtreatingptsdlikememorybytraumacontextualization AT evagunnelducourneau preventingandtreatingptsdlikememorybytraumacontextualization AT chloebouarab preventingandtreatingptsdlikememorybytraumacontextualization AT azzasellami preventingandtreatingptsdlikememorybytraumacontextualization AT alinemarighetto preventingandtreatingptsdlikememorybytraumacontextualization AT alinedesmedt preventingandtreatingptsdlikememorybytraumacontextualization
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Preventing and treating PTSD-like memory by trauma contextualization

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