Rheumatoid Arthritis Fibroblast-like Synoviocyte Suppression Mediated by PTEN Involves Survivin Gene Silencing

Abstract Survivin is a proto-oncogene biomarker known for its anti-apoptotic and cell cycle regulating properties induced by the activation of the phosphoinositide 3-kinase (PI3K)/Akt pathway. In the context of non-cancer pathology, such as rheumatoid arthritis (RA), survivin has emerged as a featur...

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Autores principales: Danna Chen, Dongdong Liu, Dan Liu, Min He, Anping Peng, Jiarui Xu, Li Lin, Fudong Luo, Lin Chen, Xianzhang Huang, Junhua Zhuang, Jianhua Xu
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Publicado: Nature Portfolio 2017
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spelling oai:doaj.org-article:983806b4b99a4dd88427de589f8bac602021-12-02T15:05:22ZRheumatoid Arthritis Fibroblast-like Synoviocyte Suppression Mediated by PTEN Involves Survivin Gene Silencing10.1038/s41598-017-00517-w2045-2322https://doaj.org/article/983806b4b99a4dd88427de589f8bac602017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00517-whttps://doaj.org/toc/2045-2322Abstract Survivin is a proto-oncogene biomarker known for its anti-apoptotic and cell cycle regulating properties induced by the activation of the phosphoinositide 3-kinase (PI3K)/Akt pathway. In the context of non-cancer pathology, such as rheumatoid arthritis (RA), survivin has emerged as a feature associated with severe joint damage and poor treatment response. Phosphatase and tensin homolog (PTEN) is a phosphatase antagonizing all classes of PI3K. The interplay between survivin oncogenic mechanisms and proliferation suppression networks in RA has remained largely elusive. This study investigated the effect of PTEN on survivin gene expression in rheumatiod arthritis fibroblast-like synoviocyte (RA-FLS). We showed for the first time that the suppression of RA-FLS was mediated by PTEN involving survivin silencing. Considering that survivin suppressants are currently available in clinical trials and clinical use, their effects in RA-FLS support a probably RA therapy to clinical practice.Danna ChenDongdong LiuDan LiuMin HeAnping PengJiarui XuLi LinFudong LuoLin ChenXianzhang HuangJunhua ZhuangJianhua XuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Danna Chen
Dongdong Liu
Dan Liu
Min He
Anping Peng
Jiarui Xu
Li Lin
Fudong Luo
Lin Chen
Xianzhang Huang
Junhua Zhuang
Jianhua Xu
Rheumatoid Arthritis Fibroblast-like Synoviocyte Suppression Mediated by PTEN Involves Survivin Gene Silencing
description Abstract Survivin is a proto-oncogene biomarker known for its anti-apoptotic and cell cycle regulating properties induced by the activation of the phosphoinositide 3-kinase (PI3K)/Akt pathway. In the context of non-cancer pathology, such as rheumatoid arthritis (RA), survivin has emerged as a feature associated with severe joint damage and poor treatment response. Phosphatase and tensin homolog (PTEN) is a phosphatase antagonizing all classes of PI3K. The interplay between survivin oncogenic mechanisms and proliferation suppression networks in RA has remained largely elusive. This study investigated the effect of PTEN on survivin gene expression in rheumatiod arthritis fibroblast-like synoviocyte (RA-FLS). We showed for the first time that the suppression of RA-FLS was mediated by PTEN involving survivin silencing. Considering that survivin suppressants are currently available in clinical trials and clinical use, their effects in RA-FLS support a probably RA therapy to clinical practice.
format article
author Danna Chen
Dongdong Liu
Dan Liu
Min He
Anping Peng
Jiarui Xu
Li Lin
Fudong Luo
Lin Chen
Xianzhang Huang
Junhua Zhuang
Jianhua Xu
author_facet Danna Chen
Dongdong Liu
Dan Liu
Min He
Anping Peng
Jiarui Xu
Li Lin
Fudong Luo
Lin Chen
Xianzhang Huang
Junhua Zhuang
Jianhua Xu
author_sort Danna Chen
title Rheumatoid Arthritis Fibroblast-like Synoviocyte Suppression Mediated by PTEN Involves Survivin Gene Silencing
title_short Rheumatoid Arthritis Fibroblast-like Synoviocyte Suppression Mediated by PTEN Involves Survivin Gene Silencing
title_full Rheumatoid Arthritis Fibroblast-like Synoviocyte Suppression Mediated by PTEN Involves Survivin Gene Silencing
title_fullStr Rheumatoid Arthritis Fibroblast-like Synoviocyte Suppression Mediated by PTEN Involves Survivin Gene Silencing
title_full_unstemmed Rheumatoid Arthritis Fibroblast-like Synoviocyte Suppression Mediated by PTEN Involves Survivin Gene Silencing
title_sort rheumatoid arthritis fibroblast-like synoviocyte suppression mediated by pten involves survivin gene silencing
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/983806b4b99a4dd88427de589f8bac60
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