Rheumatoid Arthritis Fibroblast-like Synoviocyte Suppression Mediated by PTEN Involves Survivin Gene Silencing
Abstract Survivin is a proto-oncogene biomarker known for its anti-apoptotic and cell cycle regulating properties induced by the activation of the phosphoinositide 3-kinase (PI3K)/Akt pathway. In the context of non-cancer pathology, such as rheumatoid arthritis (RA), survivin has emerged as a featur...
Guardado en:
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
|
Materias: | |
Acceso en línea: | https://doaj.org/article/983806b4b99a4dd88427de589f8bac60 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:983806b4b99a4dd88427de589f8bac60 |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:983806b4b99a4dd88427de589f8bac602021-12-02T15:05:22ZRheumatoid Arthritis Fibroblast-like Synoviocyte Suppression Mediated by PTEN Involves Survivin Gene Silencing10.1038/s41598-017-00517-w2045-2322https://doaj.org/article/983806b4b99a4dd88427de589f8bac602017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00517-whttps://doaj.org/toc/2045-2322Abstract Survivin is a proto-oncogene biomarker known for its anti-apoptotic and cell cycle regulating properties induced by the activation of the phosphoinositide 3-kinase (PI3K)/Akt pathway. In the context of non-cancer pathology, such as rheumatoid arthritis (RA), survivin has emerged as a feature associated with severe joint damage and poor treatment response. Phosphatase and tensin homolog (PTEN) is a phosphatase antagonizing all classes of PI3K. The interplay between survivin oncogenic mechanisms and proliferation suppression networks in RA has remained largely elusive. This study investigated the effect of PTEN on survivin gene expression in rheumatiod arthritis fibroblast-like synoviocyte (RA-FLS). We showed for the first time that the suppression of RA-FLS was mediated by PTEN involving survivin silencing. Considering that survivin suppressants are currently available in clinical trials and clinical use, their effects in RA-FLS support a probably RA therapy to clinical practice.Danna ChenDongdong LiuDan LiuMin HeAnping PengJiarui XuLi LinFudong LuoLin ChenXianzhang HuangJunhua ZhuangJianhua XuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
Medicine R Science Q |
spellingShingle |
Medicine R Science Q Danna Chen Dongdong Liu Dan Liu Min He Anping Peng Jiarui Xu Li Lin Fudong Luo Lin Chen Xianzhang Huang Junhua Zhuang Jianhua Xu Rheumatoid Arthritis Fibroblast-like Synoviocyte Suppression Mediated by PTEN Involves Survivin Gene Silencing |
description |
Abstract Survivin is a proto-oncogene biomarker known for its anti-apoptotic and cell cycle regulating properties induced by the activation of the phosphoinositide 3-kinase (PI3K)/Akt pathway. In the context of non-cancer pathology, such as rheumatoid arthritis (RA), survivin has emerged as a feature associated with severe joint damage and poor treatment response. Phosphatase and tensin homolog (PTEN) is a phosphatase antagonizing all classes of PI3K. The interplay between survivin oncogenic mechanisms and proliferation suppression networks in RA has remained largely elusive. This study investigated the effect of PTEN on survivin gene expression in rheumatiod arthritis fibroblast-like synoviocyte (RA-FLS). We showed for the first time that the suppression of RA-FLS was mediated by PTEN involving survivin silencing. Considering that survivin suppressants are currently available in clinical trials and clinical use, their effects in RA-FLS support a probably RA therapy to clinical practice. |
format |
article |
author |
Danna Chen Dongdong Liu Dan Liu Min He Anping Peng Jiarui Xu Li Lin Fudong Luo Lin Chen Xianzhang Huang Junhua Zhuang Jianhua Xu |
author_facet |
Danna Chen Dongdong Liu Dan Liu Min He Anping Peng Jiarui Xu Li Lin Fudong Luo Lin Chen Xianzhang Huang Junhua Zhuang Jianhua Xu |
author_sort |
Danna Chen |
title |
Rheumatoid Arthritis Fibroblast-like Synoviocyte Suppression Mediated by PTEN Involves Survivin Gene Silencing |
title_short |
Rheumatoid Arthritis Fibroblast-like Synoviocyte Suppression Mediated by PTEN Involves Survivin Gene Silencing |
title_full |
Rheumatoid Arthritis Fibroblast-like Synoviocyte Suppression Mediated by PTEN Involves Survivin Gene Silencing |
title_fullStr |
Rheumatoid Arthritis Fibroblast-like Synoviocyte Suppression Mediated by PTEN Involves Survivin Gene Silencing |
title_full_unstemmed |
Rheumatoid Arthritis Fibroblast-like Synoviocyte Suppression Mediated by PTEN Involves Survivin Gene Silencing |
title_sort |
rheumatoid arthritis fibroblast-like synoviocyte suppression mediated by pten involves survivin gene silencing |
publisher |
Nature Portfolio |
publishDate |
2017 |
url |
https://doaj.org/article/983806b4b99a4dd88427de589f8bac60 |
work_keys_str_mv |
AT dannachen rheumatoidarthritisfibroblastlikesynoviocytesuppressionmediatedbypteninvolvessurvivingenesilencing AT dongdongliu rheumatoidarthritisfibroblastlikesynoviocytesuppressionmediatedbypteninvolvessurvivingenesilencing AT danliu rheumatoidarthritisfibroblastlikesynoviocytesuppressionmediatedbypteninvolvessurvivingenesilencing AT minhe rheumatoidarthritisfibroblastlikesynoviocytesuppressionmediatedbypteninvolvessurvivingenesilencing AT anpingpeng rheumatoidarthritisfibroblastlikesynoviocytesuppressionmediatedbypteninvolvessurvivingenesilencing AT jiaruixu rheumatoidarthritisfibroblastlikesynoviocytesuppressionmediatedbypteninvolvessurvivingenesilencing AT lilin rheumatoidarthritisfibroblastlikesynoviocytesuppressionmediatedbypteninvolvessurvivingenesilencing AT fudongluo rheumatoidarthritisfibroblastlikesynoviocytesuppressionmediatedbypteninvolvessurvivingenesilencing AT linchen rheumatoidarthritisfibroblastlikesynoviocytesuppressionmediatedbypteninvolvessurvivingenesilencing AT xianzhanghuang rheumatoidarthritisfibroblastlikesynoviocytesuppressionmediatedbypteninvolvessurvivingenesilencing AT junhuazhuang rheumatoidarthritisfibroblastlikesynoviocytesuppressionmediatedbypteninvolvessurvivingenesilencing AT jianhuaxu rheumatoidarthritisfibroblastlikesynoviocytesuppressionmediatedbypteninvolvessurvivingenesilencing |
_version_ |
1718388847711092736 |