Transcriptome aberration associated with altered locomotor behavior of zebrafish (Danio rerio) caused by Waterborne Benzo[a]pyrene

Waterborne Benzo[a]pyrene (B[a]P) pollution is a global threat to aquatic organisms. The exposure to waterborne B[a]P can disrupt the normal locomotor behavior of zebrafish (Danio rerio), however, how it affect the locomotor behavior of adult zebrafish remains unclear. Herein, B[a]P at two concentra...

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Autores principales:	Yumiao Zhou, Qiang Kong, Zhihao Lin, Jinyue Ma, Huanxin Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Benzo[a]pyrene Zebrafish (Danio rerio) Transcriptomics Molecular mechanisms Locomotor behavior Oxidative stress Environmental pollution TD172-193.5 Environmental sciences GE1-350
Acceso en línea:	https://doaj.org/article/9839cb2325c84832b700271038614764
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spelling	oai:doaj.org-article:9839cb2325c84832b7002710386147642021-11-06T04:17:56ZTranscriptome aberration associated with altered locomotor behavior of zebrafish (Danio rerio) caused by Waterborne Benzo[a]pyrene0147-651310.1016/j.ecoenv.2021.112928https://doaj.org/article/9839cb2325c84832b7002710386147642021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S014765132101040Xhttps://doaj.org/toc/0147-6513Waterborne Benzo[a]pyrene (B[a]P) pollution is a global threat to aquatic organisms. The exposure to waterborne B[a]P can disrupt the normal locomotor behavior of zebrafish (Danio rerio), however, how it affect the locomotor behavior of adult zebrafish remains unclear. Herein, B[a]P at two concentrations (0.8 μg/L and 2.0 μg/L) were selected to investigate the molecular mechanisms of the affected locomotor behavior of zebrafish by B[a]P based on transcriptome profiling. Adverse effects of B[a]P exposure affecting locomotor behavior in zebrafish were studied by RNA sequencing, and the locomotion phenotype was acquired. The gene enrichment results showed that the differentially highly expressed genes (atp2a1, cdh2, aurka, fxyd1, clstn1, apoc1, mt-co1, tnnt3b, and fads2) of zebrafish are mainly enriched in adrenergic signaling in cardiomyocytes (dre04261) and locomotory behavior (GO:0007626). The movement trajectory plots showed an increase in the locomotor distance and velocity of zebrafish in the 0.8 μg/L group and the opposite in the 2.0 μg/L group. The results showed that B[a]P affects the variety of genes in zebrafish, including motor nerves, muscles, and energy supply, and ultimately leads to altered locomotor behavior.Yumiao ZhouQiang KongZhihao LinJinyue MaHuanxin ZhangElsevierarticleBenzo[a]pyreneZebrafish (Danio rerio)TranscriptomicsMolecular mechanismsLocomotor behaviorOxidative stressEnvironmental pollutionTD172-193.5Environmental sciencesGE1-350ENEcotoxicology and Environmental Safety, Vol 227, Iss , Pp 112928- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Benzo[a]pyrene Zebrafish (Danio rerio) Transcriptomics Molecular mechanisms Locomotor behavior Oxidative stress Environmental pollution TD172-193.5 Environmental sciences GE1-350
spellingShingle	Benzo[a]pyrene Zebrafish (Danio rerio) Transcriptomics Molecular mechanisms Locomotor behavior Oxidative stress Environmental pollution TD172-193.5 Environmental sciences GE1-350 Yumiao Zhou Qiang Kong Zhihao Lin Jinyue Ma Huanxin Zhang Transcriptome aberration associated with altered locomotor behavior of zebrafish (Danio rerio) caused by Waterborne Benzo[a]pyrene
description	Waterborne Benzo[a]pyrene (B[a]P) pollution is a global threat to aquatic organisms. The exposure to waterborne B[a]P can disrupt the normal locomotor behavior of zebrafish (Danio rerio), however, how it affect the locomotor behavior of adult zebrafish remains unclear. Herein, B[a]P at two concentrations (0.8 μg/L and 2.0 μg/L) were selected to investigate the molecular mechanisms of the affected locomotor behavior of zebrafish by B[a]P based on transcriptome profiling. Adverse effects of B[a]P exposure affecting locomotor behavior in zebrafish were studied by RNA sequencing, and the locomotion phenotype was acquired. The gene enrichment results showed that the differentially highly expressed genes (atp2a1, cdh2, aurka, fxyd1, clstn1, apoc1, mt-co1, tnnt3b, and fads2) of zebrafish are mainly enriched in adrenergic signaling in cardiomyocytes (dre04261) and locomotory behavior (GO:0007626). The movement trajectory plots showed an increase in the locomotor distance and velocity of zebrafish in the 0.8 μg/L group and the opposite in the 2.0 μg/L group. The results showed that B[a]P affects the variety of genes in zebrafish, including motor nerves, muscles, and energy supply, and ultimately leads to altered locomotor behavior.
format	article
author	Yumiao Zhou Qiang Kong Zhihao Lin Jinyue Ma Huanxin Zhang
author_facet	Yumiao Zhou Qiang Kong Zhihao Lin Jinyue Ma Huanxin Zhang
author_sort	Yumiao Zhou
title	Transcriptome aberration associated with altered locomotor behavior of zebrafish (Danio rerio) caused by Waterborne Benzo[a]pyrene
title_short	Transcriptome aberration associated with altered locomotor behavior of zebrafish (Danio rerio) caused by Waterborne Benzo[a]pyrene
title_full	Transcriptome aberration associated with altered locomotor behavior of zebrafish (Danio rerio) caused by Waterborne Benzo[a]pyrene
title_fullStr	Transcriptome aberration associated with altered locomotor behavior of zebrafish (Danio rerio) caused by Waterborne Benzo[a]pyrene
title_full_unstemmed	Transcriptome aberration associated with altered locomotor behavior of zebrafish (Danio rerio) caused by Waterborne Benzo[a]pyrene
title_sort	transcriptome aberration associated with altered locomotor behavior of zebrafish (danio rerio) caused by waterborne benzo[a]pyrene
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/9839cb2325c84832b700271038614764
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Transcriptome aberration associated with altered locomotor behavior of zebrafish (Danio rerio) caused by Waterborne Benzo[a]pyrene

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