Selective cell death in HIV-1-infected cells by DDX3 inhibitors leads to depletion of the inducible reservoir
DEAD-box polypeptide 3 (DDX3) is a host protein belonging to the family of ATP-dependent RNA helicases. Here, the authors demonstrate that DDX3 inhibitors reverse HIV-1 latency and selectively induce cell death in HIV-1-infected cell lines, primary CD4+ T cells and in CD4+ T cells from cART-suppress...
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Nature Portfolio
2021
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oai:doaj.org-article:983a234271bf4954b9536cec417f77df2021-12-02T13:41:32ZSelective cell death in HIV-1-infected cells by DDX3 inhibitors leads to depletion of the inducible reservoir10.1038/s41467-021-22608-z2041-1723https://doaj.org/article/983a234271bf4954b9536cec417f77df2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22608-zhttps://doaj.org/toc/2041-1723DEAD-box polypeptide 3 (DDX3) is a host protein belonging to the family of ATP-dependent RNA helicases. Here, the authors demonstrate that DDX3 inhibitors reverse HIV-1 latency and selectively induce cell death in HIV-1-infected cell lines, primary CD4+ T cells and in CD4+ T cells from cART-suppressed people living with HIV-1.Shringar RaoCynthia LunguRaquel CrespoThijs H. SteijaertAlicja GorskaRobert-Jan PalstraHenrieke A. B. PrinsWilfred van IjckenYvonne M. MuellerJeroen J. A. van KampenAnnelies VerbonPeter D. KatsikisCharles A. B. BoucherCasper RokxRob A. GrutersTokameh MahmoudiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021) |
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DOAJ |
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EN |
| topic |
Science Q |
| spellingShingle |
Science Q Shringar Rao Cynthia Lungu Raquel Crespo Thijs H. Steijaert Alicja Gorska Robert-Jan Palstra Henrieke A. B. Prins Wilfred van Ijcken Yvonne M. Mueller Jeroen J. A. van Kampen Annelies Verbon Peter D. Katsikis Charles A. B. Boucher Casper Rokx Rob A. Gruters Tokameh Mahmoudi Selective cell death in HIV-1-infected cells by DDX3 inhibitors leads to depletion of the inducible reservoir |
| description |
DEAD-box polypeptide 3 (DDX3) is a host protein belonging to the family of ATP-dependent RNA helicases. Here, the authors demonstrate that DDX3 inhibitors reverse HIV-1 latency and selectively induce cell death in HIV-1-infected cell lines, primary CD4+ T cells and in CD4+ T cells from cART-suppressed people living with HIV-1. |
| format |
article |
| author |
Shringar Rao Cynthia Lungu Raquel Crespo Thijs H. Steijaert Alicja Gorska Robert-Jan Palstra Henrieke A. B. Prins Wilfred van Ijcken Yvonne M. Mueller Jeroen J. A. van Kampen Annelies Verbon Peter D. Katsikis Charles A. B. Boucher Casper Rokx Rob A. Gruters Tokameh Mahmoudi |
| author_facet |
Shringar Rao Cynthia Lungu Raquel Crespo Thijs H. Steijaert Alicja Gorska Robert-Jan Palstra Henrieke A. B. Prins Wilfred van Ijcken Yvonne M. Mueller Jeroen J. A. van Kampen Annelies Verbon Peter D. Katsikis Charles A. B. Boucher Casper Rokx Rob A. Gruters Tokameh Mahmoudi |
| author_sort |
Shringar Rao |
| title |
Selective cell death in HIV-1-infected cells by DDX3 inhibitors leads to depletion of the inducible reservoir |
| title_short |
Selective cell death in HIV-1-infected cells by DDX3 inhibitors leads to depletion of the inducible reservoir |
| title_full |
Selective cell death in HIV-1-infected cells by DDX3 inhibitors leads to depletion of the inducible reservoir |
| title_fullStr |
Selective cell death in HIV-1-infected cells by DDX3 inhibitors leads to depletion of the inducible reservoir |
| title_full_unstemmed |
Selective cell death in HIV-1-infected cells by DDX3 inhibitors leads to depletion of the inducible reservoir |
| title_sort |
selective cell death in hiv-1-infected cells by ddx3 inhibitors leads to depletion of the inducible reservoir |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/983a234271bf4954b9536cec417f77df |
| work_keys_str_mv |
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