D-α-Tocopheryl polyethylene glycol succinate/Solutol HS 15 mixed micelles for the delivery of baohuoside I against non-small-cell lung cancer: optimization and in vitro, in vivo evaluation

D-α-Tocopheryl polyethylene glycol succinate/Solutol HS 15 mixed micelles for the delivery of baohuoside I against non-small-cell lung cancer: optimization and in vitro, in vivo evaluation

Hongmei Yan,1,2 Zhenhai Zhang,2 Xiaobin Jia,1,2 Jie Song1,2 1College of Pharmacy, Nanjing University of Chinese Medicine, 2Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Third School of Clinical Medical of Nanjing University of Chinese Medicine, Nanjing, People&r...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Yan H, Zhang Z, Jia X, Song J
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2016
Materias:
Baohuoside I- loaded mixed micelles
TPGS
Solutol HS 15
antitumor
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/983badb1f70b46c09643efa026ba1fe8
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:983badb1f70b46c09643efa026ba1fe8
record_format dspace
spelling oai:doaj.org-article:983badb1f70b46c09643efa026ba1fe82021-12-02T00:20:48ZD-α-Tocopheryl polyethylene glycol succinate/Solutol HS 15 mixed micelles for the delivery of baohuoside I against non-small-cell lung cancer: optimization and in vitro, in vivo evaluation1178-2013https://doaj.org/article/983badb1f70b46c09643efa026ba1fe82016-09-01T00:00:00Zhttps://www.dovepress.com/d-alpha-tocopheryl-polyethylene-glycol-succinatesolutol-hs-15-mixed-mi-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Hongmei Yan,1,2 Zhenhai Zhang,2 Xiaobin Jia,1,2 Jie Song1,2 1College of Pharmacy, Nanjing University of Chinese Medicine, 2Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Third School of Clinical Medical of Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China Abstract: Baohuoside I, extracted from the Herba epimedii, is an effective but a poorly soluble antitumor drug. To improve its solubility, formulation of baohuoside I-loaded mixed micelles with d-α-tocopheryl polyethylene glycol succinate and Solutol HS 15 (BTSM) has been developed in this study. We performed a systematic comparative evaluation of the antiproliferative effect, cellular uptake, antitumor efficacy, and in vivo tumor targeting of these micelles using non-small-cell lung cancer (NSCLC) A549 cells. Results showed that the obtained micelles have a mean particle size of ~62.54 nm, and the size of micelles was narrowly distributed. With the improved cellular uptake, BTSM displayed a more potent antiproliferative action on A549 cell lines than baohuoside I; half-maximal inhibitory concentration was 7.83 vs 20.37 µg/mL, respectively. The antitumor efficacy test in nude mice showed that BTSM exhibited significantly higher antitumor activity against NSCLC with lesser toxic effects on normal tissues. The imaging study for in vivo targeting demonstrated that the mixed micelles formulation achieved effective and targeted drug delivery. Therefore, BTSM might be a potential antitumor formulation. Keywords: baohuoside I-loaded mixed micelles, TPGS, Solutol HS 15, antitumorYan HZhang ZJia XSong JDove Medical PressarticleBaohuoside I- loaded mixed micellesTPGSSolutol HS 15antitumorMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 11, Pp 4563-4571 (2016)
institution DOAJ
collection DOAJ
language EN
topic Baohuoside I- loaded mixed micelles
TPGS
Solutol HS 15
antitumor
Medicine (General)
R5-920
spellingShingle Baohuoside I- loaded mixed micelles
TPGS
Solutol HS 15
antitumor
Medicine (General)
R5-920
Yan H
Zhang Z
Jia X
Song J
D-α-Tocopheryl polyethylene glycol succinate/Solutol HS 15 mixed micelles for the delivery of baohuoside I against non-small-cell lung cancer: optimization and in vitro, in vivo evaluation
description Hongmei Yan,1,2 Zhenhai Zhang,2 Xiaobin Jia,1,2 Jie Song1,2 1College of Pharmacy, Nanjing University of Chinese Medicine, 2Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Third School of Clinical Medical of Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China Abstract: Baohuoside I, extracted from the Herba epimedii, is an effective but a poorly soluble antitumor drug. To improve its solubility, formulation of baohuoside I-loaded mixed micelles with d-α-tocopheryl polyethylene glycol succinate and Solutol HS 15 (BTSM) has been developed in this study. We performed a systematic comparative evaluation of the antiproliferative effect, cellular uptake, antitumor efficacy, and in vivo tumor targeting of these micelles using non-small-cell lung cancer (NSCLC) A549 cells. Results showed that the obtained micelles have a mean particle size of ~62.54 nm, and the size of micelles was narrowly distributed. With the improved cellular uptake, BTSM displayed a more potent antiproliferative action on A549 cell lines than baohuoside I; half-maximal inhibitory concentration was 7.83 vs 20.37 µg/mL, respectively. The antitumor efficacy test in nude mice showed that BTSM exhibited significantly higher antitumor activity against NSCLC with lesser toxic effects on normal tissues. The imaging study for in vivo targeting demonstrated that the mixed micelles formulation achieved effective and targeted drug delivery. Therefore, BTSM might be a potential antitumor formulation. Keywords: baohuoside I-loaded mixed micelles, TPGS, Solutol HS 15, antitumor
format article
author Yan H
Zhang Z
Jia X
Song J
author_facet Yan H
Zhang Z
Jia X
Song J
author_sort Yan H
title D-α-Tocopheryl polyethylene glycol succinate/Solutol HS 15 mixed micelles for the delivery of baohuoside I against non-small-cell lung cancer: optimization and in vitro, in vivo evaluation
title_short D-α-Tocopheryl polyethylene glycol succinate/Solutol HS 15 mixed micelles for the delivery of baohuoside I against non-small-cell lung cancer: optimization and in vitro, in vivo evaluation
title_full D-α-Tocopheryl polyethylene glycol succinate/Solutol HS 15 mixed micelles for the delivery of baohuoside I against non-small-cell lung cancer: optimization and in vitro, in vivo evaluation
title_fullStr D-α-Tocopheryl polyethylene glycol succinate/Solutol HS 15 mixed micelles for the delivery of baohuoside I against non-small-cell lung cancer: optimization and in vitro, in vivo evaluation
title_full_unstemmed D-α-Tocopheryl polyethylene glycol succinate/Solutol HS 15 mixed micelles for the delivery of baohuoside I against non-small-cell lung cancer: optimization and in vitro, in vivo evaluation
title_sort d-α-tocopheryl polyethylene glycol succinate/solutol hs 15 mixed micelles for the delivery of baohuoside i against non-small-cell lung cancer: optimization and in vitro, in vivo evaluation
publisher Dove Medical Press
publishDate 2016
url https://doaj.org/article/983badb1f70b46c09643efa026ba1fe8
work_keys_str_mv AT yanh dalphatocopherylpolyethyleneglycolsuccinatesolutolhs15mixedmicellesforthedeliveryofbaohuosideiagainstnonsmallcelllungcanceroptimizationandinvitroinvivoevaluation
AT zhangz dalphatocopherylpolyethyleneglycolsuccinatesolutolhs15mixedmicellesforthedeliveryofbaohuosideiagainstnonsmallcelllungcanceroptimizationandinvitroinvivoevaluation
AT jiax dalphatocopherylpolyethyleneglycolsuccinatesolutolhs15mixedmicellesforthedeliveryofbaohuosideiagainstnonsmallcelllungcanceroptimizationandinvitroinvivoevaluation
AT songj dalphatocopherylpolyethyleneglycolsuccinatesolutolhs15mixedmicellesforthedeliveryofbaohuosideiagainstnonsmallcelllungcanceroptimizationandinvitroinvivoevaluation
_version_ 1718403817298460672

Ejemplares similares