Non-tumor necrosis factor-based biologic therapies for rheumatoid arthritis: present, future, and insights into pathogenesis

Filipe Seguro Paula,1 José Delgado Alves1,2 1Immunomediated Systemic Diseases Unit, Department of Medicine 4, Fernando Fonseca Hospital, Amadora, 2Center for the Study of Chronic Diseases, Department of Pharmacology, Faculty of Medical Sciences, Lisbon, Portugal Abstract: The way rheumato...

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Autores principales:	Paula FS, Delgado Alves J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/983fbd9ba1f64aeb8a6a7d7068c7a5f5
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spelling	oai:doaj.org-article:983fbd9ba1f64aeb8a6a7d7068c7a5f52021-12-02T02:08:36ZNon-tumor necrosis factor-based biologic therapies for rheumatoid arthritis: present, future, and insights into pathogenesis1177-54751177-5491https://doaj.org/article/983fbd9ba1f64aeb8a6a7d7068c7a5f52013-12-01T00:00:00Zhttp://www.dovepress.com/non-tumor-necrosis-factor-based-biologic-therapies-for-rheumatoid-arth-a15230https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491Filipe Seguro Paula,1 José Delgado Alves1,2 1Immunomediated Systemic Diseases Unit, Department of Medicine 4, Fernando Fonseca Hospital, Amadora, 2Center for the Study of Chronic Diseases, Department of Pharmacology, Faculty of Medical Sciences, Lisbon, Portugal Abstract: The way rheumatoid arthritis is treated has changed dramatically with the introduction of anti-tumor necrosis factor (anti-TNF) biologics. Nevertheless, many patients still have less than adequate control of their disease activity even with these therapeutic regimens, and current knowledge fails to explain all the data already gathered. There is now a wide range of drugs from different classes of biologic disease-modifying anti-rheumatic drugs available (and soon this number will increase significantly), that provides the opportunity to address each patient as a particular case and thereby optimize medical intervention. Currently available biologics for the treatment of rheumatoid arthritis apart from anti-TNF-based therapies are reviewed, along with an analysis of the new insights they provide into the pathogenesis of the disease and a discussion of future prospects in the area. Keywords: rheumatoid arthritis, non-anti-tumor necrosis factor, treatment, pathogenesisPaula FSDelgado Alves JDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2014, Iss default, Pp 1-12 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Paula FS Delgado Alves J Non-tumor necrosis factor-based biologic therapies for rheumatoid arthritis: present, future, and insights into pathogenesis
description	Filipe Seguro Paula,1 José Delgado Alves1,2 1Immunomediated Systemic Diseases Unit, Department of Medicine 4, Fernando Fonseca Hospital, Amadora, 2Center for the Study of Chronic Diseases, Department of Pharmacology, Faculty of Medical Sciences, Lisbon, Portugal Abstract: The way rheumatoid arthritis is treated has changed dramatically with the introduction of anti-tumor necrosis factor (anti-TNF) biologics. Nevertheless, many patients still have less than adequate control of their disease activity even with these therapeutic regimens, and current knowledge fails to explain all the data already gathered. There is now a wide range of drugs from different classes of biologic disease-modifying anti-rheumatic drugs available (and soon this number will increase significantly), that provides the opportunity to address each patient as a particular case and thereby optimize medical intervention. Currently available biologics for the treatment of rheumatoid arthritis apart from anti-TNF-based therapies are reviewed, along with an analysis of the new insights they provide into the pathogenesis of the disease and a discussion of future prospects in the area. Keywords: rheumatoid arthritis, non-anti-tumor necrosis factor, treatment, pathogenesis
format	article
author	Paula FS Delgado Alves J
author_facet	Paula FS Delgado Alves J
author_sort	Paula FS
title	Non-tumor necrosis factor-based biologic therapies for rheumatoid arthritis: present, future, and insights into pathogenesis
title_short	Non-tumor necrosis factor-based biologic therapies for rheumatoid arthritis: present, future, and insights into pathogenesis
title_full	Non-tumor necrosis factor-based biologic therapies for rheumatoid arthritis: present, future, and insights into pathogenesis
title_fullStr	Non-tumor necrosis factor-based biologic therapies for rheumatoid arthritis: present, future, and insights into pathogenesis
title_full_unstemmed	Non-tumor necrosis factor-based biologic therapies for rheumatoid arthritis: present, future, and insights into pathogenesis
title_sort	non-tumor necrosis factor-based biologic therapies for rheumatoid arthritis: present, future, and insights into pathogenesis
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/983fbd9ba1f64aeb8a6a7d7068c7a5f5
work_keys_str_mv	AT paulafs nontumornecrosisfactorbasedbiologictherapiesforrheumatoidarthritispresentfutureandinsightsintopathogenesis AT delgadoalvesj nontumornecrosisfactorbasedbiologictherapiesforrheumatoidarthritispresentfutureandinsightsintopathogenesis
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Non-tumor necrosis factor-based biologic therapies for rheumatoid arthritis: present, future, and insights into pathogenesis

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