HIV-1 Genomes Are Enriched in Memory CD4 <sup>+</sup> T-Cells with Short Half-Lives
The design of future HIV-1 curative therapies requires a more thorough understanding of the distribution of genetically intact HIV-1 within T-cell subsets as well as the cellular mechanisms that maintain this reservoir. These genetically intact and presumably replication-competent proviruses make u...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
American Society for Microbiology
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/9840134545d946e5afd4453b7f75a3e7 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:9840134545d946e5afd4453b7f75a3e7 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:9840134545d946e5afd4453b7f75a3e72021-11-03T21:52:35Z HIV-1 Genomes Are Enriched in Memory CD4 <sup>+</sup> T-Cells with Short Half-Lives 2150-751110.1128/mBio.02447-21https://doaj.org/article/9840134545d946e5afd4453b7f75a3e72021-10-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02447-21https://doaj.org/toc/2150-7511 The design of future HIV-1 curative therapies requires a more thorough understanding of the distribution of genetically intact HIV-1 within T-cell subsets as well as the cellular mechanisms that maintain this reservoir. These genetically intact and presumably replication-competent proviruses make up the latent HIV-1 reservoir.Vincent MorcillaCharline Bacchus-SouffanKatie FisherBethany A. HorsburghBonnie HienerXiao Qian WangTimothy E. SchlubMark FitchRebecca HohFrederick M. HechtJeffrey N. MartinSteven G. DeeksMarc K. HellersteinJoseph M. McCunePeter W. HuntSarah PalmerAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 5 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Microbiology QR1-502 |
| spellingShingle |
Microbiology QR1-502 Vincent Morcilla Charline Bacchus-Souffan Katie Fisher Bethany A. Horsburgh Bonnie Hiener Xiao Qian Wang Timothy E. Schlub Mark Fitch Rebecca Hoh Frederick M. Hecht Jeffrey N. Martin Steven G. Deeks Marc K. Hellerstein Joseph M. McCune Peter W. Hunt Sarah Palmer HIV-1 Genomes Are Enriched in Memory CD4 <sup>+</sup> T-Cells with Short Half-Lives |
| description |
The design of future HIV-1 curative therapies requires a more thorough understanding of the distribution of genetically intact HIV-1 within T-cell subsets as well as the cellular mechanisms that maintain this reservoir. These genetically intact and presumably replication-competent proviruses make up the latent HIV-1 reservoir. |
| format |
article |
| author |
Vincent Morcilla Charline Bacchus-Souffan Katie Fisher Bethany A. Horsburgh Bonnie Hiener Xiao Qian Wang Timothy E. Schlub Mark Fitch Rebecca Hoh Frederick M. Hecht Jeffrey N. Martin Steven G. Deeks Marc K. Hellerstein Joseph M. McCune Peter W. Hunt Sarah Palmer |
| author_facet |
Vincent Morcilla Charline Bacchus-Souffan Katie Fisher Bethany A. Horsburgh Bonnie Hiener Xiao Qian Wang Timothy E. Schlub Mark Fitch Rebecca Hoh Frederick M. Hecht Jeffrey N. Martin Steven G. Deeks Marc K. Hellerstein Joseph M. McCune Peter W. Hunt Sarah Palmer |
| author_sort |
Vincent Morcilla |
| title |
HIV-1 Genomes Are Enriched in Memory CD4
<sup>+</sup>
T-Cells with Short Half-Lives
|
| title_short |
HIV-1 Genomes Are Enriched in Memory CD4
<sup>+</sup>
T-Cells with Short Half-Lives
|
| title_full |
HIV-1 Genomes Are Enriched in Memory CD4
<sup>+</sup>
T-Cells with Short Half-Lives
|
| title_fullStr |
HIV-1 Genomes Are Enriched in Memory CD4
<sup>+</sup>
T-Cells with Short Half-Lives
|
| title_full_unstemmed |
HIV-1 Genomes Are Enriched in Memory CD4
<sup>+</sup>
T-Cells with Short Half-Lives
|
| title_sort |
hiv-1 genomes are enriched in memory cd4
<sup>+</sup>
t-cells with short half-lives |
| publisher |
American Society for Microbiology |
| publishDate |
2021 |
| url |
https://doaj.org/article/9840134545d946e5afd4453b7f75a3e7 |
| work_keys_str_mv |
AT vincentmorcilla hiv1genomesareenrichedinmemorycd4supsuptcellswithshorthalflives AT charlinebacchussouffan hiv1genomesareenrichedinmemorycd4supsuptcellswithshorthalflives AT katiefisher hiv1genomesareenrichedinmemorycd4supsuptcellswithshorthalflives AT bethanyahorsburgh hiv1genomesareenrichedinmemorycd4supsuptcellswithshorthalflives AT bonniehiener hiv1genomesareenrichedinmemorycd4supsuptcellswithshorthalflives AT xiaoqianwang hiv1genomesareenrichedinmemorycd4supsuptcellswithshorthalflives AT timothyeschlub hiv1genomesareenrichedinmemorycd4supsuptcellswithshorthalflives AT markfitch hiv1genomesareenrichedinmemorycd4supsuptcellswithshorthalflives AT rebeccahoh hiv1genomesareenrichedinmemorycd4supsuptcellswithshorthalflives AT frederickmhecht hiv1genomesareenrichedinmemorycd4supsuptcellswithshorthalflives AT jeffreynmartin hiv1genomesareenrichedinmemorycd4supsuptcellswithshorthalflives AT stevengdeeks hiv1genomesareenrichedinmemorycd4supsuptcellswithshorthalflives AT marckhellerstein hiv1genomesareenrichedinmemorycd4supsuptcellswithshorthalflives AT josephmmccune hiv1genomesareenrichedinmemorycd4supsuptcellswithshorthalflives AT peterwhunt hiv1genomesareenrichedinmemorycd4supsuptcellswithshorthalflives AT sarahpalmer hiv1genomesareenrichedinmemorycd4supsuptcellswithshorthalflives |
| _version_ |
1718445347216293888 |