Convergent and divergent brain structural and functional abnormalities associated with developmental dyslexia
Brain abnormalities in the reading network have been repeatedly reported in individuals with developmental dyslexia (DD); however, it is still not totally understood where the structural and functional abnormalities are consistent/inconsistent across languages. In the current multimodal meta-analysi...
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eLife Sciences Publications Ltd
2021
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oai:doaj.org-article:984280618dea43dea953a08b59f184302021-11-29T12:14:04ZConvergent and divergent brain structural and functional abnormalities associated with developmental dyslexia10.7554/eLife.695232050-084Xe69523https://doaj.org/article/984280618dea43dea953a08b59f184302021-09-01T00:00:00Zhttps://elifesciences.org/articles/69523https://doaj.org/toc/2050-084XBrain abnormalities in the reading network have been repeatedly reported in individuals with developmental dyslexia (DD); however, it is still not totally understood where the structural and functional abnormalities are consistent/inconsistent across languages. In the current multimodal meta-analysis, we found convergent structural and functional alterations in the left superior temporal gyrus across languages, suggesting a neural signature of DD. We found greater reduction in grey matter volume and brain activation in the left inferior frontal gyrus in morpho-syllabic languages (e.g. Chinese) than in alphabetic languages, and greater reduction in brain activation in the left middle temporal gyrus and fusiform gyrus in alphabetic languages than in morpho-syllabic languages. These language differences are explained as consequences of being DD while learning a specific language. In addition, we also found brain regions that showed increased grey matter volume and brain activation, presumably suggesting compensations and brain regions that showed inconsistent alterations in brain structure and function. Our study provides important insights about the etiology of DD from a cross-linguistic perspective with considerations of consistency/inconsistency between structural and functional alterations.Xiaohui YanKe JiangHui LiZiyi WangKyle PerkinsFan CaoeLife Sciences Publications Ltdarticledyslexiamultimodal meta-analysisalphabetic languagemorpho-syllabic languageMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021) |
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DOAJ |
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EN |
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dyslexia multimodal meta-analysis alphabetic language morpho-syllabic language Medicine R Science Q Biology (General) QH301-705.5 |
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dyslexia multimodal meta-analysis alphabetic language morpho-syllabic language Medicine R Science Q Biology (General) QH301-705.5 Xiaohui Yan Ke Jiang Hui Li Ziyi Wang Kyle Perkins Fan Cao Convergent and divergent brain structural and functional abnormalities associated with developmental dyslexia |
| description |
Brain abnormalities in the reading network have been repeatedly reported in individuals with developmental dyslexia (DD); however, it is still not totally understood where the structural and functional abnormalities are consistent/inconsistent across languages. In the current multimodal meta-analysis, we found convergent structural and functional alterations in the left superior temporal gyrus across languages, suggesting a neural signature of DD. We found greater reduction in grey matter volume and brain activation in the left inferior frontal gyrus in morpho-syllabic languages (e.g. Chinese) than in alphabetic languages, and greater reduction in brain activation in the left middle temporal gyrus and fusiform gyrus in alphabetic languages than in morpho-syllabic languages. These language differences are explained as consequences of being DD while learning a specific language. In addition, we also found brain regions that showed increased grey matter volume and brain activation, presumably suggesting compensations and brain regions that showed inconsistent alterations in brain structure and function. Our study provides important insights about the etiology of DD from a cross-linguistic perspective with considerations of consistency/inconsistency between structural and functional alterations. |
| format |
article |
| author |
Xiaohui Yan Ke Jiang Hui Li Ziyi Wang Kyle Perkins Fan Cao |
| author_facet |
Xiaohui Yan Ke Jiang Hui Li Ziyi Wang Kyle Perkins Fan Cao |
| author_sort |
Xiaohui Yan |
| title |
Convergent and divergent brain structural and functional abnormalities associated with developmental dyslexia |
| title_short |
Convergent and divergent brain structural and functional abnormalities associated with developmental dyslexia |
| title_full |
Convergent and divergent brain structural and functional abnormalities associated with developmental dyslexia |
| title_fullStr |
Convergent and divergent brain structural and functional abnormalities associated with developmental dyslexia |
| title_full_unstemmed |
Convergent and divergent brain structural and functional abnormalities associated with developmental dyslexia |
| title_sort |
convergent and divergent brain structural and functional abnormalities associated with developmental dyslexia |
| publisher |
eLife Sciences Publications Ltd |
| publishDate |
2021 |
| url |
https://doaj.org/article/984280618dea43dea953a08b59f18430 |
| work_keys_str_mv |
AT xiaohuiyan convergentanddivergentbrainstructuralandfunctionalabnormalitiesassociatedwithdevelopmentaldyslexia AT kejiang convergentanddivergentbrainstructuralandfunctionalabnormalitiesassociatedwithdevelopmentaldyslexia AT huili convergentanddivergentbrainstructuralandfunctionalabnormalitiesassociatedwithdevelopmentaldyslexia AT ziyiwang convergentanddivergentbrainstructuralandfunctionalabnormalitiesassociatedwithdevelopmentaldyslexia AT kyleperkins convergentanddivergentbrainstructuralandfunctionalabnormalitiesassociatedwithdevelopmentaldyslexia AT fancao convergentanddivergentbrainstructuralandfunctionalabnormalitiesassociatedwithdevelopmentaldyslexia |
| _version_ |
1718407415938940928 |