Specificity of end resection pathways for double-strand break regions containing ribonucleotides and base lesions

DNA double-strand break repair by homologous recombination initiates with nucleolytic resection of the 5’ DNA strand at the break ends. Here, the authors reveal that the lesion context influences the action and efficiency of the long range resection factors EXO1 and BLM-DNA2.

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Autores principales:	James M. Daley, Nozomi Tomimatsu, Grace Hooks, Weibin Wang, Adam S. Miller, Xiaoyu Xue, Kevin A. Nguyen, Hardeep Kaur, Elizabeth Williamson, Bipasha Mukherjee, Robert Hromas, Sandeep Burma, Patrick Sung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/984479d037a94bbc940c8e7db07e22e0
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spelling	oai:doaj.org-article:984479d037a94bbc940c8e7db07e22e02021-12-02T17:40:33ZSpecificity of end resection pathways for double-strand break regions containing ribonucleotides and base lesions10.1038/s41467-020-16903-42041-1723https://doaj.org/article/984479d037a94bbc940c8e7db07e22e02020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16903-4https://doaj.org/toc/2041-1723DNA double-strand break repair by homologous recombination initiates with nucleolytic resection of the 5’ DNA strand at the break ends. Here, the authors reveal that the lesion context influences the action and efficiency of the long range resection factors EXO1 and BLM-DNA2.James M. DaleyNozomi TomimatsuGrace HooksWeibin WangAdam S. MillerXiaoyu XueKevin A. NguyenHardeep KaurElizabeth WilliamsonBipasha MukherjeeRobert HromasSandeep BurmaPatrick SungNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q James M. Daley Nozomi Tomimatsu Grace Hooks Weibin Wang Adam S. Miller Xiaoyu Xue Kevin A. Nguyen Hardeep Kaur Elizabeth Williamson Bipasha Mukherjee Robert Hromas Sandeep Burma Patrick Sung Specificity of end resection pathways for double-strand break regions containing ribonucleotides and base lesions
description	DNA double-strand break repair by homologous recombination initiates with nucleolytic resection of the 5’ DNA strand at the break ends. Here, the authors reveal that the lesion context influences the action and efficiency of the long range resection factors EXO1 and BLM-DNA2.
format	article
author	James M. Daley Nozomi Tomimatsu Grace Hooks Weibin Wang Adam S. Miller Xiaoyu Xue Kevin A. Nguyen Hardeep Kaur Elizabeth Williamson Bipasha Mukherjee Robert Hromas Sandeep Burma Patrick Sung
author_facet	James M. Daley Nozomi Tomimatsu Grace Hooks Weibin Wang Adam S. Miller Xiaoyu Xue Kevin A. Nguyen Hardeep Kaur Elizabeth Williamson Bipasha Mukherjee Robert Hromas Sandeep Burma Patrick Sung
author_sort	James M. Daley
title	Specificity of end resection pathways for double-strand break regions containing ribonucleotides and base lesions
title_short	Specificity of end resection pathways for double-strand break regions containing ribonucleotides and base lesions
title_full	Specificity of end resection pathways for double-strand break regions containing ribonucleotides and base lesions
title_fullStr	Specificity of end resection pathways for double-strand break regions containing ribonucleotides and base lesions
title_full_unstemmed	Specificity of end resection pathways for double-strand break regions containing ribonucleotides and base lesions
title_sort	specificity of end resection pathways for double-strand break regions containing ribonucleotides and base lesions
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/984479d037a94bbc940c8e7db07e22e0
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Specificity of end resection pathways for double-strand break regions containing ribonucleotides and base lesions

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