Influence of Epinephrine and Medetomidine on Systemic Absorption of Lidocaine Applied Epidurally in Anesthetized Swine

Epinephrine and alpha 2 agonist drugs are often used with epidural anesthesia to minimize local anesthetic systemic absorption, as well as to prolong the duration of the block. The aim of the current study was to determine by which extent epinephrine and medetomidine influenced lidocaine systemic ab...

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Autores principales:	Marija Lipar, Rajka Turner, Berislav Radišić, Lovorka Grgurević, Igor Erjavec, Nataša Brajenović, Irena Brčić Karačonji, Marko Samardžija, Dražen Vnuk
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2014
Materias:	epidural lidocaine serum concentration epinephrine medetomidine swine Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/98447b38bea34364899b0d5652609796
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spelling	oai:doaj.org-article:98447b38bea34364899b0d56526097962021-11-17T21:27:52ZInfluence of Epinephrine and Medetomidine on Systemic Absorption of Lidocaine Applied Epidurally in Anesthetized Swine1820-744810.2478/acve-2014-0043https://doaj.org/article/98447b38bea34364899b0d56526097962014-12-01T00:00:00Zhttps://doi.org/10.2478/acve-2014-0043https://doaj.org/toc/1820-7448Epinephrine and alpha 2 agonist drugs are often used with epidural anesthesia to minimize local anesthetic systemic absorption, as well as to prolong the duration of the block. The aim of the current study was to determine by which extent epinephrine and medetomidine influenced lidocaine systemic absorption rate following epidural application. This was achieved by monitoring the serum lidocaine concentration in a porcine model. During general anesthesia, the first group received epidurally plane lidocaine, the second received lidocaine containing epinephrine (1 : 80.000), and the third lidocaine with medetomidine (15 μg/kg). Venous blood samples were taken before and 5, 10, 20, 30, 45, 60 and 90 minutes following epidural administration of the anesthetic. The effects of epinephrine and medetomidine were comparable. They both failed to cause a significant decrease in serum lidocaine concentration (p>0.05). In these settings we were unable to demonstrate a greater capacity of these two adrenergic agonists for reducing lidocaine systemic uptake and, accordingly, its systemic toxicity potential.Marija LiparRajka TurnerBerislav RadišićLovorka GrgurevićIgor ErjavecNataša BrajenovićIrena Brčić KaračonjiMarko SamardžijaDražen VnukSciendoarticleepidurallidocaineserum concentrationepinephrinemedetomidineswineVeterinary medicineSF600-1100ENActa Veterinaria, Vol 64, Iss 4, Pp 456-465 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	epidural lidocaine serum concentration epinephrine medetomidine swine Veterinary medicine SF600-1100
spellingShingle	epidural lidocaine serum concentration epinephrine medetomidine swine Veterinary medicine SF600-1100 Marija Lipar Rajka Turner Berislav Radišić Lovorka Grgurević Igor Erjavec Nataša Brajenović Irena Brčić Karačonji Marko Samardžija Dražen Vnuk Influence of Epinephrine and Medetomidine on Systemic Absorption of Lidocaine Applied Epidurally in Anesthetized Swine
description	Epinephrine and alpha 2 agonist drugs are often used with epidural anesthesia to minimize local anesthetic systemic absorption, as well as to prolong the duration of the block. The aim of the current study was to determine by which extent epinephrine and medetomidine influenced lidocaine systemic absorption rate following epidural application. This was achieved by monitoring the serum lidocaine concentration in a porcine model. During general anesthesia, the first group received epidurally plane lidocaine, the second received lidocaine containing epinephrine (1 : 80.000), and the third lidocaine with medetomidine (15 μg/kg). Venous blood samples were taken before and 5, 10, 20, 30, 45, 60 and 90 minutes following epidural administration of the anesthetic. The effects of epinephrine and medetomidine were comparable. They both failed to cause a significant decrease in serum lidocaine concentration (p>0.05). In these settings we were unable to demonstrate a greater capacity of these two adrenergic agonists for reducing lidocaine systemic uptake and, accordingly, its systemic toxicity potential.
format	article
author	Marija Lipar Rajka Turner Berislav Radišić Lovorka Grgurević Igor Erjavec Nataša Brajenović Irena Brčić Karačonji Marko Samardžija Dražen Vnuk
author_facet	Marija Lipar Rajka Turner Berislav Radišić Lovorka Grgurević Igor Erjavec Nataša Brajenović Irena Brčić Karačonji Marko Samardžija Dražen Vnuk
author_sort	Marija Lipar
title	Influence of Epinephrine and Medetomidine on Systemic Absorption of Lidocaine Applied Epidurally in Anesthetized Swine
title_short	Influence of Epinephrine and Medetomidine on Systemic Absorption of Lidocaine Applied Epidurally in Anesthetized Swine
title_full	Influence of Epinephrine and Medetomidine on Systemic Absorption of Lidocaine Applied Epidurally in Anesthetized Swine
title_fullStr	Influence of Epinephrine and Medetomidine on Systemic Absorption of Lidocaine Applied Epidurally in Anesthetized Swine
title_full_unstemmed	Influence of Epinephrine and Medetomidine on Systemic Absorption of Lidocaine Applied Epidurally in Anesthetized Swine
title_sort	influence of epinephrine and medetomidine on systemic absorption of lidocaine applied epidurally in anesthetized swine
publisher	Sciendo
publishDate	2014
url	https://doaj.org/article/98447b38bea34364899b0d5652609796
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Influence of Epinephrine and Medetomidine on Systemic Absorption of Lidocaine Applied Epidurally in Anesthetized Swine

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