Effects of the b-blockers on the functional state of patients with ventricular arrhythmias

Sudden cardiac death and the heaviest arrhythmic events are connected to ventricular arrhythmias (VA). The issue of optimization of drug therapy for VA remains relevant. Given the possible multidirectional effects of antiarrhythmic drugs on the functional state, in order to determine the effectivene...

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Autores principales:	Iosif Z. Shubitidze, Vitalii G. Tregubov
Formato:	article
Lenguaje:	RU
Publicado:	IP Morozov P.V. 2021
Materias:	functional state ventricular arrhythmias bisoprolol nebivolol sotalol Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/9848ab7522b2457aa9368adbeeb7e4e8
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spelling	oai:doaj.org-article:9848ab7522b2457aa9368adbeeb7e4e82021-11-30T16:09:16ZEffects of the b-blockers on the functional state of patients with ventricular arrhythmias2075-082X2542-218910.26442/2075082X.2021.1.200246https://doaj.org/article/9848ab7522b2457aa9368adbeeb7e4e82021-03-01T00:00:00Zhttps://syst-hypertension.ru/2075-082X/article/viewFile/65108/47927https://doaj.org/toc/2075-082Xhttps://doaj.org/toc/2542-2189Sudden cardiac death and the heaviest arrhythmic events are connected to ventricular arrhythmias (VA). The issue of optimization of drug therapy for VA remains relevant. Given the possible multidirectional effects of antiarrhythmic drugs on the functional state, in order to determine the effectiveness of pharmacotherapy in patients with VA it is advisable to use a stepwise integrated approach. Aim. Compare the effects of bisoprolol, nebivolol and sotalol on the functional state of patients with VA. Materials and methods. 120 patients with VA of grade IIV based on the В. Lown grading system, III groups based on J. Bigger grading system against the background of essential hypertension or its combination with coronary heart disease took part in the research, they were randomized into three groups for treatment with bisoprolol, nebivolol and sotalol. As part of combination therapy, patients were administered lisinopril, and if indicated, acetylsalicylic acid, atorvastatin. Initially and after 24 weeks of therapy the following was done: quantitative assessment of regulatory-adaptive status by cardio-respiratory synchronism test, treadmill test, six-minute walk test, subjective assessment of quality of life, all-day monitoring of blood pressure and electrocardiogram. Results. With comparable hypotensive and antiarrhythmic effects, therapy with nebivolol had a positive effect on the regulatory-adaptive status, had a better effect on exercise tolerance in comparison with bisoprolol and sotalol, more improved the quality of life, in comparison with bisoprolol and sotalol. Conclusion. In patients with VA against the background of essential hypertension or its combination with coronary heart disease as part of combination therapy the use of nebivolol may be preferable to bisoprolol or sotalol due to a more pronounced positive effect on the functional state.Iosif Z. ShubitidzeVitalii G. TregubovIP Morozov P.V.articlefunctional stateventricular arrhythmiasbisoprololnebivololsotalolDiseases of the circulatory (Cardiovascular) systemRC666-701RUСистемные гипертензии, Vol 18, Iss 1, Pp 19-24 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	functional state ventricular arrhythmias bisoprolol nebivolol sotalol Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	functional state ventricular arrhythmias bisoprolol nebivolol sotalol Diseases of the circulatory (Cardiovascular) system RC666-701 Iosif Z. Shubitidze Vitalii G. Tregubov Effects of the b-blockers on the functional state of patients with ventricular arrhythmias
description	Sudden cardiac death and the heaviest arrhythmic events are connected to ventricular arrhythmias (VA). The issue of optimization of drug therapy for VA remains relevant. Given the possible multidirectional effects of antiarrhythmic drugs on the functional state, in order to determine the effectiveness of pharmacotherapy in patients with VA it is advisable to use a stepwise integrated approach. Aim. Compare the effects of bisoprolol, nebivolol and sotalol on the functional state of patients with VA. Materials and methods. 120 patients with VA of grade IIV based on the В. Lown grading system, III groups based on J. Bigger grading system against the background of essential hypertension or its combination with coronary heart disease took part in the research, they were randomized into three groups for treatment with bisoprolol, nebivolol and sotalol. As part of combination therapy, patients were administered lisinopril, and if indicated, acetylsalicylic acid, atorvastatin. Initially and after 24 weeks of therapy the following was done: quantitative assessment of regulatory-adaptive status by cardio-respiratory synchronism test, treadmill test, six-minute walk test, subjective assessment of quality of life, all-day monitoring of blood pressure and electrocardiogram. Results. With comparable hypotensive and antiarrhythmic effects, therapy with nebivolol had a positive effect on the regulatory-adaptive status, had a better effect on exercise tolerance in comparison with bisoprolol and sotalol, more improved the quality of life, in comparison with bisoprolol and sotalol. Conclusion. In patients with VA against the background of essential hypertension or its combination with coronary heart disease as part of combination therapy the use of nebivolol may be preferable to bisoprolol or sotalol due to a more pronounced positive effect on the functional state.
format	article
author	Iosif Z. Shubitidze Vitalii G. Tregubov
author_facet	Iosif Z. Shubitidze Vitalii G. Tregubov
author_sort	Iosif Z. Shubitidze
title	Effects of the b-blockers on the functional state of patients with ventricular arrhythmias
title_short	Effects of the b-blockers on the functional state of patients with ventricular arrhythmias
title_full	Effects of the b-blockers on the functional state of patients with ventricular arrhythmias
title_fullStr	Effects of the b-blockers on the functional state of patients with ventricular arrhythmias
title_full_unstemmed	Effects of the b-blockers on the functional state of patients with ventricular arrhythmias
title_sort	effects of the b-blockers on the functional state of patients with ventricular arrhythmias
publisher	IP Morozov P.V.
publishDate	2021
url	https://doaj.org/article/9848ab7522b2457aa9368adbeeb7e4e8
work_keys_str_mv	AT iosifzshubitidze effectsofthebblockersonthefunctionalstateofpatientswithventriculararrhythmias AT vitaliigtregubov effectsofthebblockersonthefunctionalstateofpatientswithventriculararrhythmias
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Effects of the b-blockers on the functional state of patients with ventricular arrhythmias

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