Individual Macular Layer Evaluation with Spectral Domain Optical Coherence Tomography in Normal and Glaucomatous Eyes

Fernanda Mari Fagundes Fujihara,1,2 Paulo Augusto de Arruda Mello,3 Rodrigo Leivas Lindenmeyer,1,4 Helena Messinger Pakter,1,4,5 Jaco Lavinsky,1,4 Camila Zanella Benfica,1 Nedio Castoldi,1 Egidio Picetti,5 Daniel Lavinsky,1,4 Alessandro Finkelsztejn,1,4 Fabio Lavinsky1,3 1Department of Ophthalmology...

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Autores principales:	Fujihara FMF, de Arruda Mello PA, Lindenmeyer RL, Pakter HM, Lavinsky J, Benfica CZ, Castoldi N, Picetti E, Lavinsky D, Finkelsztejn A, Lavinsky F
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	glaucoma optical coherence tomography macula optic nerve visual field Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/985311c43eac40cdbecb859f3c9115f0
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spelling	oai:doaj.org-article:985311c43eac40cdbecb859f3c9115f02021-12-02T09:03:20ZIndividual Macular Layer Evaluation with Spectral Domain Optical Coherence Tomography in Normal and Glaucomatous Eyes1177-5483https://doaj.org/article/985311c43eac40cdbecb859f3c9115f02020-06-01T00:00:00Zhttps://www.dovepress.com/individual-macular-layer-evaluation-with-spectral-domain-optical-coher-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Fernanda Mari Fagundes Fujihara,1,2 Paulo Augusto de Arruda Mello,3 Rodrigo Leivas Lindenmeyer,1,4 Helena Messinger Pakter,1,4,5 Jaco Lavinsky,1,4 Camila Zanella Benfica,1 Nedio Castoldi,1 Egidio Picetti,5 Daniel Lavinsky,1,4 Alessandro Finkelsztejn,1,4 Fabio Lavinsky1,3 1Department of Ophthalmology, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil; 2Hospital Banco de Olhos de Porto Alegre, Porto Alegre, RS, Brazil; 3Department of Ophthalmology, Paulista School of Medicine, São Paulo Hospital, Federal University of São Paulo, São Paulo, SP, Brazil; 4Department of Ophthalmology, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; 5Department of Ophthalmology, Hospital Nossa Senhora da Conceição, Porto Alegre, RS, BrazilCorrespondence: Fabio Lavinsky Email ylavinsky@hotmail.comPurpose: To evaluate differences in the thickness of the individual macular layers between early, moderate, and severe glaucomatous eyes and compare them with healthy controls.Patients and Methods: Subjects with glaucoma presenting typical optic nerve head findings, high intraocular pressure with or without visual field (VF) damage and normal controls were included. All participants underwent 24– 2 perimetry and spectral-domain OCT. Patients were divided into three groups (early, moderate, and severe) based on the mean deviation of the VF and a healthy control group. The device segmented the layers automatically, and their measurements were plotted using the means of the sectors of the inner (3mm) and outer (6mm) circles of the ETDRS grid.Results: A total of 109 eyes qualified for the study: 14 in the control group and 52, 18 and 25 in the early, moderate and severe groups, respectively. Mean age was 66.13 (SD=12.38). The mean thickness of the circumpapillary retinal nerve fiber layer (RNFL), total macular thickness (TMT), macular RNFL, ganglion cell layer (GCL) and inner plexiform layer (IPL) were significantly different between the 4 groups, with progressive decrease in thickness. Significant overall difference was found for the inner nuclear layer (INL), and the severe glaucoma group presented thicker measurements than controls and early glaucoma. Outer nuclear layer (ONL) was thinner in severe glaucoma group compared with early glaucoma group.Conclusion: Individual macular layer measurement using the inner and outer circles of the ETDRS grid is useful to evaluate different stages of glaucoma. The INL thickening and ONL thinning in advanced glaucoma should be explored in the future studies.Keywords: glaucoma, optical coherence tomography, macula, optic nerve, visual fieldFujihara FMFde Arruda Mello PALindenmeyer RLPakter HMLavinsky JBenfica CZCastoldi NPicetti ELavinsky DFinkelsztejn ALavinsky FDove Medical Pressarticleglaucomaoptical coherence tomographymaculaoptic nervevisual fieldOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 1591-1599 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	glaucoma optical coherence tomography macula optic nerve visual field Ophthalmology RE1-994
spellingShingle	glaucoma optical coherence tomography macula optic nerve visual field Ophthalmology RE1-994 Fujihara FMF de Arruda Mello PA Lindenmeyer RL Pakter HM Lavinsky J Benfica CZ Castoldi N Picetti E Lavinsky D Finkelsztejn A Lavinsky F Individual Macular Layer Evaluation with Spectral Domain Optical Coherence Tomography in Normal and Glaucomatous Eyes
description	Fernanda Mari Fagundes Fujihara,1,2 Paulo Augusto de Arruda Mello,3 Rodrigo Leivas Lindenmeyer,1,4 Helena Messinger Pakter,1,4,5 Jaco Lavinsky,1,4 Camila Zanella Benfica,1 Nedio Castoldi,1 Egidio Picetti,5 Daniel Lavinsky,1,4 Alessandro Finkelsztejn,1,4 Fabio Lavinsky1,3 1Department of Ophthalmology, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil; 2Hospital Banco de Olhos de Porto Alegre, Porto Alegre, RS, Brazil; 3Department of Ophthalmology, Paulista School of Medicine, São Paulo Hospital, Federal University of São Paulo, São Paulo, SP, Brazil; 4Department of Ophthalmology, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; 5Department of Ophthalmology, Hospital Nossa Senhora da Conceição, Porto Alegre, RS, BrazilCorrespondence: Fabio Lavinsky Email ylavinsky@hotmail.comPurpose: To evaluate differences in the thickness of the individual macular layers between early, moderate, and severe glaucomatous eyes and compare them with healthy controls.Patients and Methods: Subjects with glaucoma presenting typical optic nerve head findings, high intraocular pressure with or without visual field (VF) damage and normal controls were included. All participants underwent 24– 2 perimetry and spectral-domain OCT. Patients were divided into three groups (early, moderate, and severe) based on the mean deviation of the VF and a healthy control group. The device segmented the layers automatically, and their measurements were plotted using the means of the sectors of the inner (3mm) and outer (6mm) circles of the ETDRS grid.Results: A total of 109 eyes qualified for the study: 14 in the control group and 52, 18 and 25 in the early, moderate and severe groups, respectively. Mean age was 66.13 (SD=12.38). The mean thickness of the circumpapillary retinal nerve fiber layer (RNFL), total macular thickness (TMT), macular RNFL, ganglion cell layer (GCL) and inner plexiform layer (IPL) were significantly different between the 4 groups, with progressive decrease in thickness. Significant overall difference was found for the inner nuclear layer (INL), and the severe glaucoma group presented thicker measurements than controls and early glaucoma. Outer nuclear layer (ONL) was thinner in severe glaucoma group compared with early glaucoma group.Conclusion: Individual macular layer measurement using the inner and outer circles of the ETDRS grid is useful to evaluate different stages of glaucoma. The INL thickening and ONL thinning in advanced glaucoma should be explored in the future studies.Keywords: glaucoma, optical coherence tomography, macula, optic nerve, visual field
format	article
author	Fujihara FMF de Arruda Mello PA Lindenmeyer RL Pakter HM Lavinsky J Benfica CZ Castoldi N Picetti E Lavinsky D Finkelsztejn A Lavinsky F
author_facet	Fujihara FMF de Arruda Mello PA Lindenmeyer RL Pakter HM Lavinsky J Benfica CZ Castoldi N Picetti E Lavinsky D Finkelsztejn A Lavinsky F
author_sort	Fujihara FMF
title	Individual Macular Layer Evaluation with Spectral Domain Optical Coherence Tomography in Normal and Glaucomatous Eyes
title_short	Individual Macular Layer Evaluation with Spectral Domain Optical Coherence Tomography in Normal and Glaucomatous Eyes
title_full	Individual Macular Layer Evaluation with Spectral Domain Optical Coherence Tomography in Normal and Glaucomatous Eyes
title_fullStr	Individual Macular Layer Evaluation with Spectral Domain Optical Coherence Tomography in Normal and Glaucomatous Eyes
title_full_unstemmed	Individual Macular Layer Evaluation with Spectral Domain Optical Coherence Tomography in Normal and Glaucomatous Eyes
title_sort	individual macular layer evaluation with spectral domain optical coherence tomography in normal and glaucomatous eyes
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/985311c43eac40cdbecb859f3c9115f0
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Individual Macular Layer Evaluation with Spectral Domain Optical Coherence Tomography in Normal and Glaucomatous Eyes

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