Role of normal sleep and sleep apnea in human memory processing

Shilpi Ahuja,1 Rebecca K Chen,1 Korey Kam,1 Ward D Pettibone,1 Ricardo S Osorio,2 Andrew W Varga1 1Mount Sinai Integrative Sleep Center, Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA; 2Center for Brain Health, Department of Psych...

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Autores principales:	Ahuja S, Chen RK, Kam K, Pettibone WD, Osorio RS, Varga AW
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	consolidation learning REM sleep sleep spindles slow oscillations Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/9856d0945a024ef897a3b82b1e7fa2ea
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spelling	oai:doaj.org-article:9856d0945a024ef897a3b82b1e7fa2ea2021-12-02T02:12:07ZRole of normal sleep and sleep apnea in human memory processing1179-1608https://doaj.org/article/9856d0945a024ef897a3b82b1e7fa2ea2018-09-01T00:00:00Zhttps://www.dovepress.com/role-of-normal-sleep-and-sleep-apnea-in-human-memory-processing-peer-reviewed-article-NSShttps://doaj.org/toc/1179-1608Shilpi Ahuja,1 Rebecca K Chen,1 Korey Kam,1 Ward D Pettibone,1 Ricardo S Osorio,2 Andrew W Varga1 1Mount Sinai Integrative Sleep Center, Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA; 2Center for Brain Health, Department of Psychiatry, NYU School of Medicine, New York, NY, USA Abstract: A fundamental problem in the field of obstructive sleep apnea (OSA) and memory is that it has historically minimized the basic neurobiology of sleep’s role in memory. Memory formation has been classically divided into phases of encoding, processing/consolidation, and retrieval. An abundance of evidence suggests that sleep plays a critical role specifically in the processing/consolidation phase, but may do so differentially for memories that were encoded using particular brain circuits. In this review, we discuss some of the more established evidence for sleep’s function in the processing of declarative, spatial navigational, emotional, and motor/procedural memories and more emerging evidence highlighting sleep’s importance in higher order functions such as probabilistic learning, transitive inference, and category/gist learning. Furthermore, we discuss sleep’s capacity for memory augmentation through targeted/cued memory reactivation. OSA – by virtue of its associated sleep fragmentation, intermittent hypoxia, and potential brain structural effects – is well positioned to specifically impact the processing/consolidation phase, but testing this possibility requires experimental paradigms in which memory encoding and retrieval are separated by a period of sleep with and without the presence of OSA. We argue that such paradigms should focus on the specific types of memory tasks for which sleep has been shown to have a significant effect. We discuss the small number of studies in which this has been done, in which OSA nearly uniformly negatively impacts offline memory processing. When periods of offline processing are minimal or absent and do not contain sleep, as is the case in the broad literature on OSA and memory, the effects of OSA on memory are far less consistent. Keywords: consolidation, learning, REM sleep, sleep spindles, slow oscillationsAhuja SChen RKKam KPettibone WDOsorio RSVarga AWDove Medical PressarticleconsolidationlearningREM sleepsleep spindlesslow oscillationsPsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol Volume 10, Pp 255-269 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	consolidation learning REM sleep sleep spindles slow oscillations Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	consolidation learning REM sleep sleep spindles slow oscillations Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Ahuja S Chen RK Kam K Pettibone WD Osorio RS Varga AW Role of normal sleep and sleep apnea in human memory processing
description	Shilpi Ahuja,1 Rebecca K Chen,1 Korey Kam,1 Ward D Pettibone,1 Ricardo S Osorio,2 Andrew W Varga1 1Mount Sinai Integrative Sleep Center, Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA; 2Center for Brain Health, Department of Psychiatry, NYU School of Medicine, New York, NY, USA Abstract: A fundamental problem in the field of obstructive sleep apnea (OSA) and memory is that it has historically minimized the basic neurobiology of sleep’s role in memory. Memory formation has been classically divided into phases of encoding, processing/consolidation, and retrieval. An abundance of evidence suggests that sleep plays a critical role specifically in the processing/consolidation phase, but may do so differentially for memories that were encoded using particular brain circuits. In this review, we discuss some of the more established evidence for sleep’s function in the processing of declarative, spatial navigational, emotional, and motor/procedural memories and more emerging evidence highlighting sleep’s importance in higher order functions such as probabilistic learning, transitive inference, and category/gist learning. Furthermore, we discuss sleep’s capacity for memory augmentation through targeted/cued memory reactivation. OSA – by virtue of its associated sleep fragmentation, intermittent hypoxia, and potential brain structural effects – is well positioned to specifically impact the processing/consolidation phase, but testing this possibility requires experimental paradigms in which memory encoding and retrieval are separated by a period of sleep with and without the presence of OSA. We argue that such paradigms should focus on the specific types of memory tasks for which sleep has been shown to have a significant effect. We discuss the small number of studies in which this has been done, in which OSA nearly uniformly negatively impacts offline memory processing. When periods of offline processing are minimal or absent and do not contain sleep, as is the case in the broad literature on OSA and memory, the effects of OSA on memory are far less consistent. Keywords: consolidation, learning, REM sleep, sleep spindles, slow oscillations
format	article
author	Ahuja S Chen RK Kam K Pettibone WD Osorio RS Varga AW
author_facet	Ahuja S Chen RK Kam K Pettibone WD Osorio RS Varga AW
author_sort	Ahuja S
title	Role of normal sleep and sleep apnea in human memory processing
title_short	Role of normal sleep and sleep apnea in human memory processing
title_full	Role of normal sleep and sleep apnea in human memory processing
title_fullStr	Role of normal sleep and sleep apnea in human memory processing
title_full_unstemmed	Role of normal sleep and sleep apnea in human memory processing
title_sort	role of normal sleep and sleep apnea in human memory processing
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/9856d0945a024ef897a3b82b1e7fa2ea
work_keys_str_mv	AT ahujas roleofnormalsleepandsleepapneainhumanmemoryprocessing AT chenrk roleofnormalsleepandsleepapneainhumanmemoryprocessing AT kamk roleofnormalsleepandsleepapneainhumanmemoryprocessing AT pettibonewd roleofnormalsleepandsleepapneainhumanmemoryprocessing AT osoriors roleofnormalsleepandsleepapneainhumanmemoryprocessing AT vargaaw roleofnormalsleepandsleepapneainhumanmemoryprocessing
_version_	1718402610812157952

Role of normal sleep and sleep apnea in human memory processing

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