Fatty liver index is independently associated with deterioration of renal function during a 10-year period in healthy subjects
Abstract A potential link between chronic kidney disease (CKD) and non-alcoholic fatty liver disease (NAFLD) has been suggested. We investigated the relationship between fatty liver index (FLI), a noninvasive and simple predictor of NAFLD, and the development of CKD defined as estimated glomerular f...
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Nature Portfolio
2021
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oai:doaj.org-article:9857da550b694a85be6ce587cf9f6b9a2021-12-02T16:45:21ZFatty liver index is independently associated with deterioration of renal function during a 10-year period in healthy subjects10.1038/s41598-021-88025-w2045-2322https://doaj.org/article/9857da550b694a85be6ce587cf9f6b9a2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88025-whttps://doaj.org/toc/2045-2322Abstract A potential link between chronic kidney disease (CKD) and non-alcoholic fatty liver disease (NAFLD) has been suggested. We investigated the relationship between fatty liver index (FLI), a noninvasive and simple predictor of NAFLD, and the development of CKD defined as estimated glomerular filtration rate < 60 mL/min/1.73 m2 or positive for urinary protein during a 10-year follow-up period in subjects who received annual health examinations (n = 28,890). After exclusion of CKD at baseline, a total of 14,163 subjects (male/female: 9077/5086) were recruited. During the 10-year period, 1458 males (16.1%) and 737 females (14.5%) had new onset of CKD. Multivariable Cox proportional hazard models with a restricted cubic spline showed that hazard ratios (HRs) of CKD development increased with a higher FLI at baseline in both males and females after adjustment of confounders. When divided by tertiles of FLI level at baseline (T1 ~ T3), the adjusted risk of CKD development in the T3 group (HR [95% confidence interval], male/female: 1.33 [1.16–1.54]/1.33 [1.08–1.63]) was significantly higher than that in both sexes in the T1 group as the reference. The addition of FLI into traditional risk factors significantly improved the discriminatory capability for predicting CKD. In conclusion, a high level of FLI predicts the development of CKD in both sexes in a general population.Satoko TakahashiMarenao TanakaMasato FuruhashiNorihito MoniwaMasayuki KoyamaYukimura HigashiuraArata OsanamiYufu GochoHirofumi OhnishiKeita NumataTakashi HisasueNagisa HanawaTetsuji MiuraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
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Medicine R Science Q |
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Medicine R Science Q Satoko Takahashi Marenao Tanaka Masato Furuhashi Norihito Moniwa Masayuki Koyama Yukimura Higashiura Arata Osanami Yufu Gocho Hirofumi Ohnishi Keita Numata Takashi Hisasue Nagisa Hanawa Tetsuji Miura Fatty liver index is independently associated with deterioration of renal function during a 10-year period in healthy subjects |
| description |
Abstract A potential link between chronic kidney disease (CKD) and non-alcoholic fatty liver disease (NAFLD) has been suggested. We investigated the relationship between fatty liver index (FLI), a noninvasive and simple predictor of NAFLD, and the development of CKD defined as estimated glomerular filtration rate < 60 mL/min/1.73 m2 or positive for urinary protein during a 10-year follow-up period in subjects who received annual health examinations (n = 28,890). After exclusion of CKD at baseline, a total of 14,163 subjects (male/female: 9077/5086) were recruited. During the 10-year period, 1458 males (16.1%) and 737 females (14.5%) had new onset of CKD. Multivariable Cox proportional hazard models with a restricted cubic spline showed that hazard ratios (HRs) of CKD development increased with a higher FLI at baseline in both males and females after adjustment of confounders. When divided by tertiles of FLI level at baseline (T1 ~ T3), the adjusted risk of CKD development in the T3 group (HR [95% confidence interval], male/female: 1.33 [1.16–1.54]/1.33 [1.08–1.63]) was significantly higher than that in both sexes in the T1 group as the reference. The addition of FLI into traditional risk factors significantly improved the discriminatory capability for predicting CKD. In conclusion, a high level of FLI predicts the development of CKD in both sexes in a general population. |
| format |
article |
| author |
Satoko Takahashi Marenao Tanaka Masato Furuhashi Norihito Moniwa Masayuki Koyama Yukimura Higashiura Arata Osanami Yufu Gocho Hirofumi Ohnishi Keita Numata Takashi Hisasue Nagisa Hanawa Tetsuji Miura |
| author_facet |
Satoko Takahashi Marenao Tanaka Masato Furuhashi Norihito Moniwa Masayuki Koyama Yukimura Higashiura Arata Osanami Yufu Gocho Hirofumi Ohnishi Keita Numata Takashi Hisasue Nagisa Hanawa Tetsuji Miura |
| author_sort |
Satoko Takahashi |
| title |
Fatty liver index is independently associated with deterioration of renal function during a 10-year period in healthy subjects |
| title_short |
Fatty liver index is independently associated with deterioration of renal function during a 10-year period in healthy subjects |
| title_full |
Fatty liver index is independently associated with deterioration of renal function during a 10-year period in healthy subjects |
| title_fullStr |
Fatty liver index is independently associated with deterioration of renal function during a 10-year period in healthy subjects |
| title_full_unstemmed |
Fatty liver index is independently associated with deterioration of renal function during a 10-year period in healthy subjects |
| title_sort |
fatty liver index is independently associated with deterioration of renal function during a 10-year period in healthy subjects |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/9857da550b694a85be6ce587cf9f6b9a |
| work_keys_str_mv |
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