Default-mode network changes in Huntington's disease: an integrated MRI study of functional connectivity and morphometry.

Previous MRI studies of functional connectivity in pre-symptomatic mutation carriers of Huntington's disease (HD) have shown dysfunction of the Default-Mode Network (DMN). No data however are currently available on the DMN alterations in the symptomatic stages of the disease, which are characte...

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Autores principales:	Mario Quarantelli, Elena Salvatore, Sara Maria Delle Acque Giorgio, Alessandro Filla, Amedeo Cervo, Cinzia Valeria Russo, Sirio Cocozza, Marco Massarelli, Arturo Brunetti, Giuseppe De Michele
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/985a3d6ae10e4875a2b1556f8c8f618b
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spelling	oai:doaj.org-article:985a3d6ae10e4875a2b1556f8c8f618b2021-11-18T08:59:00ZDefault-mode network changes in Huntington's disease: an integrated MRI study of functional connectivity and morphometry.1932-620310.1371/journal.pone.0072159https://doaj.org/article/985a3d6ae10e4875a2b1556f8c8f618b2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23977239/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Previous MRI studies of functional connectivity in pre-symptomatic mutation carriers of Huntington's disease (HD) have shown dysfunction of the Default-Mode Network (DMN). No data however are currently available on the DMN alterations in the symptomatic stages of the disease, which are characterized by cortical atrophy involving several DMN nodes. We assessed DMN integrity and its possible correlations with motor and cognitive symptoms in 26 symptomatic HD patients as compared to 22 normal volunteers, by analyzing resting state functional MRI data, using the Precuneal Cortex/Posterior Cingulate Cortices (PC/PCC) as seed, controlling at voxel level for the effect of atrophy by co-varying for gray matter volume. Direct correlation with PC/PCC was decreased, without correlation with atrophy, in the ventral medial prefrontal cortex (including anterior cingulate and subgenual cortex), right dorso-medial prefrontal cortex, and in the right inferior parietal cortex (mainly involving the angular gyrus). Negative correlations with PC/PCC were decreased bilaterally in the inferior parietal cortices, while a cluster in the right middle occipital gyrus presented increased correlation with PC/PCC. DMN changes in the ventral medial prefrontal cortex significantly correlated with the performance at the Stroop test (p = .0002). Widespread DMN changes, not correlating with the atrophy of the involved nodes, are present in symptomatic HD patients, and correlate with cognitive disturbances.Mario QuarantelliElena SalvatoreSara Maria Delle Acque GiorgioAlessandro FillaAmedeo CervoCinzia Valeria RussoSirio CocozzaMarco MassarelliArturo BrunettiGiuseppe De MichelePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 8, p e72159 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mario Quarantelli Elena Salvatore Sara Maria Delle Acque Giorgio Alessandro Filla Amedeo Cervo Cinzia Valeria Russo Sirio Cocozza Marco Massarelli Arturo Brunetti Giuseppe De Michele Default-mode network changes in Huntington's disease: an integrated MRI study of functional connectivity and morphometry.
description	Previous MRI studies of functional connectivity in pre-symptomatic mutation carriers of Huntington's disease (HD) have shown dysfunction of the Default-Mode Network (DMN). No data however are currently available on the DMN alterations in the symptomatic stages of the disease, which are characterized by cortical atrophy involving several DMN nodes. We assessed DMN integrity and its possible correlations with motor and cognitive symptoms in 26 symptomatic HD patients as compared to 22 normal volunteers, by analyzing resting state functional MRI data, using the Precuneal Cortex/Posterior Cingulate Cortices (PC/PCC) as seed, controlling at voxel level for the effect of atrophy by co-varying for gray matter volume. Direct correlation with PC/PCC was decreased, without correlation with atrophy, in the ventral medial prefrontal cortex (including anterior cingulate and subgenual cortex), right dorso-medial prefrontal cortex, and in the right inferior parietal cortex (mainly involving the angular gyrus). Negative correlations with PC/PCC were decreased bilaterally in the inferior parietal cortices, while a cluster in the right middle occipital gyrus presented increased correlation with PC/PCC. DMN changes in the ventral medial prefrontal cortex significantly correlated with the performance at the Stroop test (p = .0002). Widespread DMN changes, not correlating with the atrophy of the involved nodes, are present in symptomatic HD patients, and correlate with cognitive disturbances.
format	article
author	Mario Quarantelli Elena Salvatore Sara Maria Delle Acque Giorgio Alessandro Filla Amedeo Cervo Cinzia Valeria Russo Sirio Cocozza Marco Massarelli Arturo Brunetti Giuseppe De Michele
author_facet	Mario Quarantelli Elena Salvatore Sara Maria Delle Acque Giorgio Alessandro Filla Amedeo Cervo Cinzia Valeria Russo Sirio Cocozza Marco Massarelli Arturo Brunetti Giuseppe De Michele
author_sort	Mario Quarantelli
title	Default-mode network changes in Huntington's disease: an integrated MRI study of functional connectivity and morphometry.
title_short	Default-mode network changes in Huntington's disease: an integrated MRI study of functional connectivity and morphometry.
title_full	Default-mode network changes in Huntington's disease: an integrated MRI study of functional connectivity and morphometry.
title_fullStr	Default-mode network changes in Huntington's disease: an integrated MRI study of functional connectivity and morphometry.
title_full_unstemmed	Default-mode network changes in Huntington's disease: an integrated MRI study of functional connectivity and morphometry.
title_sort	default-mode network changes in huntington's disease: an integrated mri study of functional connectivity and morphometry.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/985a3d6ae10e4875a2b1556f8c8f618b
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Default-mode network changes in Huntington's disease: an integrated MRI study of functional connectivity and morphometry.

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