Magnetic tri-bead microrobot assisted near-infrared triggered combined photothermal and chemotherapy of cancer cells

Abstract Magnetic micro/nanorobots attracted much attention in biomedical fields because of their precise movement, manipulation, and targeting abilities. However, there is a lack of research on intelligent micro/nanorobots with stimuli-responsive drug delivery mechanisms for cancer therapy. To addr...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xiaoxia Song, Zhi Chen, Xue Zhang, Junfeng Xiong, Teng Jiang, Zihan Wang, Xinran Geng, U Kei Cheang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/985a9e2dfe594091b842b7343cd1cd1d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:985a9e2dfe594091b842b7343cd1cd1d
record_format	dspace
spelling	oai:doaj.org-article:985a9e2dfe594091b842b7343cd1cd1d2021-12-02T15:51:13ZMagnetic tri-bead microrobot assisted near-infrared triggered combined photothermal and chemotherapy of cancer cells10.1038/s41598-021-87010-72045-2322https://doaj.org/article/985a9e2dfe594091b842b7343cd1cd1d2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87010-7https://doaj.org/toc/2045-2322Abstract Magnetic micro/nanorobots attracted much attention in biomedical fields because of their precise movement, manipulation, and targeting abilities. However, there is a lack of research on intelligent micro/nanorobots with stimuli-responsive drug delivery mechanisms for cancer therapy. To address this issue, we developed a type of strong covalently bound tri-bead drug delivery microrobots with NIR photothermal response azobenzene molecules attached to their carboxylic surface groups. The tri-bead microrobots are magnetic and showed good cytocompatibility even when their concentration is up to 200 µg/mL. In vitro photothermal experiments demonstrated fast NIR-responsive photothermal property; the microrobots were heated to 50 °C in 4 min, which triggered a significant increase in drug release. Motion control of the microrobots inside a microchannel demonstrated the feasibility of targeted therapy on tumor cells. Finally, experiments with lung cancer cells demonstrated the effectiveness of targeted chemo-photothermal therapy and were validated by cell viability assays. These results indicated that tri-bead microrobots have excellent potential for targeted chemo-photothermal therapy for lung cancer cell treatment.Xiaoxia SongZhi ChenXue ZhangJunfeng XiongTeng JiangZihan WangXinran GengU Kei CheangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaoxia Song Zhi Chen Xue Zhang Junfeng Xiong Teng Jiang Zihan Wang Xinran Geng U Kei Cheang Magnetic tri-bead microrobot assisted near-infrared triggered combined photothermal and chemotherapy of cancer cells
description	Abstract Magnetic micro/nanorobots attracted much attention in biomedical fields because of their precise movement, manipulation, and targeting abilities. However, there is a lack of research on intelligent micro/nanorobots with stimuli-responsive drug delivery mechanisms for cancer therapy. To address this issue, we developed a type of strong covalently bound tri-bead drug delivery microrobots with NIR photothermal response azobenzene molecules attached to their carboxylic surface groups. The tri-bead microrobots are magnetic and showed good cytocompatibility even when their concentration is up to 200 µg/mL. In vitro photothermal experiments demonstrated fast NIR-responsive photothermal property; the microrobots were heated to 50 °C in 4 min, which triggered a significant increase in drug release. Motion control of the microrobots inside a microchannel demonstrated the feasibility of targeted therapy on tumor cells. Finally, experiments with lung cancer cells demonstrated the effectiveness of targeted chemo-photothermal therapy and were validated by cell viability assays. These results indicated that tri-bead microrobots have excellent potential for targeted chemo-photothermal therapy for lung cancer cell treatment.
format	article
author	Xiaoxia Song Zhi Chen Xue Zhang Junfeng Xiong Teng Jiang Zihan Wang Xinran Geng U Kei Cheang
author_facet	Xiaoxia Song Zhi Chen Xue Zhang Junfeng Xiong Teng Jiang Zihan Wang Xinran Geng U Kei Cheang
author_sort	Xiaoxia Song
title	Magnetic tri-bead microrobot assisted near-infrared triggered combined photothermal and chemotherapy of cancer cells
title_short	Magnetic tri-bead microrobot assisted near-infrared triggered combined photothermal and chemotherapy of cancer cells
title_full	Magnetic tri-bead microrobot assisted near-infrared triggered combined photothermal and chemotherapy of cancer cells
title_fullStr	Magnetic tri-bead microrobot assisted near-infrared triggered combined photothermal and chemotherapy of cancer cells
title_full_unstemmed	Magnetic tri-bead microrobot assisted near-infrared triggered combined photothermal and chemotherapy of cancer cells
title_sort	magnetic tri-bead microrobot assisted near-infrared triggered combined photothermal and chemotherapy of cancer cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/985a9e2dfe594091b842b7343cd1cd1d
work_keys_str_mv	AT xiaoxiasong magnetictribeadmicrorobotassistednearinfraredtriggeredcombinedphotothermalandchemotherapyofcancercells AT zhichen magnetictribeadmicrorobotassistednearinfraredtriggeredcombinedphotothermalandchemotherapyofcancercells AT xuezhang magnetictribeadmicrorobotassistednearinfraredtriggeredcombinedphotothermalandchemotherapyofcancercells AT junfengxiong magnetictribeadmicrorobotassistednearinfraredtriggeredcombinedphotothermalandchemotherapyofcancercells AT tengjiang magnetictribeadmicrorobotassistednearinfraredtriggeredcombinedphotothermalandchemotherapyofcancercells AT zihanwang magnetictribeadmicrorobotassistednearinfraredtriggeredcombinedphotothermalandchemotherapyofcancercells AT xinrangeng magnetictribeadmicrorobotassistednearinfraredtriggeredcombinedphotothermalandchemotherapyofcancercells AT ukeicheang magnetictribeadmicrorobotassistednearinfraredtriggeredcombinedphotothermalandchemotherapyofcancercells
_version_	1718385648162832384

Magnetic tri-bead microrobot assisted near-infrared triggered combined photothermal and chemotherapy of cancer cells

Ejemplares similares