CLINICAL AND IMMUNOLOGICAL EFFICIENCY OF ADAMANTANE DERIVATIVE IN THERAPY OF ASTHENIC DISORDERS IN EARLY FORMS OF CHRONIC BRAIN ISCHEMIA

A non-specific stress-induced overload of limbic-reticular emotiogenic structures under the deficiency conditions of endogenous energy resources is the main mechanism for development of asthenic disorders with early developing chronic brain ischemia among veterans of recent wars, upo...

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Autores principales:	E. V. Davydova, A. V. Zurochka
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2017
Materias:	chronic brain ischemia asthenic syndrome ladasten immunotropic action Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/985bde6ab0b048fb897547a27ae7c9b8
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spelling	oai:doaj.org-article:985bde6ab0b048fb897547a27ae7c9b82021-11-18T08:03:46ZCLINICAL AND IMMUNOLOGICAL EFFICIENCY OF ADAMANTANE DERIVATIVE IN THERAPY OF ASTHENIC DISORDERS IN EARLY FORMS OF CHRONIC BRAIN ISCHEMIA1563-06252313-741X10.15789/1563-0625-2017-4-441-452https://doaj.org/article/985bde6ab0b048fb897547a27ae7c9b82017-08-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1315https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XA non-specific stress-induced overload of limbic-reticular emotiogenic structures under the deficiency conditions of endogenous energy resources is the main mechanism for development of asthenic disorders with early developing chronic brain ischemia among veterans of recent wars, upon their return to civilian life. We observed a group of 30 Afghan veterans with early forms of chronic brain ischemia and manifestations of psychogenic asthenic syndrome. When treating psychogenic asthenic syndrome in the veterans of recent military conflicts, an adamantane derivative administered as a course treatment, at a dose of 50 mg 2 times daily causes psychostimulant, anxiolytic, vegetotropic, antihypotymic, and hypnotic pharmacological effects, with reduction of main psychopathological and somatoneurological symptoms.A notable immunotropic effect of the drug was revealed, being expressed as enhanced immunopoiesis; activation of innate defense mechanisms; expansion of Treg lymphocyte population, suggestive for increased suppressor effect upon the mechanisms of autoimmune aggression; implementation of cell differentiation/ proliferative effect; anti-apoptogenic properties; anti-inflammatory activity (reduction of TNFα, IL-8, hsCRP, along with IL-2 increase) associated with reduced functional activity of mononuclear cells; vasotropic action expressed as normalized balance of vasoactive factors (nitric oxide, endothelin-1), decrease of nitrotyrosine concentration, suggesting the nitrosylation stress reduction. The actoprotective drug effect is implemented due to a combined psychostimulant, vasotropic, proliferative effects. It may be expressed in terms of higher efficiency and optimization of systemic hemodynamic parameters.E. V. DavydovaA. V. ZurochkaSPb RAACIarticlechronic brain ischemiaasthenic syndromeladastenimmunotropic actionImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 19, Iss 4, Pp 441-452 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	chronic brain ischemia asthenic syndrome ladasten immunotropic action Immunologic diseases. Allergy RC581-607
spellingShingle	chronic brain ischemia asthenic syndrome ladasten immunotropic action Immunologic diseases. Allergy RC581-607 E. V. Davydova A. V. Zurochka CLINICAL AND IMMUNOLOGICAL EFFICIENCY OF ADAMANTANE DERIVATIVE IN THERAPY OF ASTHENIC DISORDERS IN EARLY FORMS OF CHRONIC BRAIN ISCHEMIA
description	A non-specific stress-induced overload of limbic-reticular emotiogenic structures under the deficiency conditions of endogenous energy resources is the main mechanism for development of asthenic disorders with early developing chronic brain ischemia among veterans of recent wars, upon their return to civilian life. We observed a group of 30 Afghan veterans with early forms of chronic brain ischemia and manifestations of psychogenic asthenic syndrome. When treating psychogenic asthenic syndrome in the veterans of recent military conflicts, an adamantane derivative administered as a course treatment, at a dose of 50 mg 2 times daily causes psychostimulant, anxiolytic, vegetotropic, antihypotymic, and hypnotic pharmacological effects, with reduction of main psychopathological and somatoneurological symptoms.A notable immunotropic effect of the drug was revealed, being expressed as enhanced immunopoiesis; activation of innate defense mechanisms; expansion of Treg lymphocyte population, suggestive for increased suppressor effect upon the mechanisms of autoimmune aggression; implementation of cell differentiation/ proliferative effect; anti-apoptogenic properties; anti-inflammatory activity (reduction of TNFα, IL-8, hsCRP, along with IL-2 increase) associated with reduced functional activity of mononuclear cells; vasotropic action expressed as normalized balance of vasoactive factors (nitric oxide, endothelin-1), decrease of nitrotyrosine concentration, suggesting the nitrosylation stress reduction. The actoprotective drug effect is implemented due to a combined psychostimulant, vasotropic, proliferative effects. It may be expressed in terms of higher efficiency and optimization of systemic hemodynamic parameters.
format	article
author	E. V. Davydova A. V. Zurochka
author_facet	E. V. Davydova A. V. Zurochka
author_sort	E. V. Davydova
title	CLINICAL AND IMMUNOLOGICAL EFFICIENCY OF ADAMANTANE DERIVATIVE IN THERAPY OF ASTHENIC DISORDERS IN EARLY FORMS OF CHRONIC BRAIN ISCHEMIA
title_short	CLINICAL AND IMMUNOLOGICAL EFFICIENCY OF ADAMANTANE DERIVATIVE IN THERAPY OF ASTHENIC DISORDERS IN EARLY FORMS OF CHRONIC BRAIN ISCHEMIA
title_full	CLINICAL AND IMMUNOLOGICAL EFFICIENCY OF ADAMANTANE DERIVATIVE IN THERAPY OF ASTHENIC DISORDERS IN EARLY FORMS OF CHRONIC BRAIN ISCHEMIA
title_fullStr	CLINICAL AND IMMUNOLOGICAL EFFICIENCY OF ADAMANTANE DERIVATIVE IN THERAPY OF ASTHENIC DISORDERS IN EARLY FORMS OF CHRONIC BRAIN ISCHEMIA
title_full_unstemmed	CLINICAL AND IMMUNOLOGICAL EFFICIENCY OF ADAMANTANE DERIVATIVE IN THERAPY OF ASTHENIC DISORDERS IN EARLY FORMS OF CHRONIC BRAIN ISCHEMIA
title_sort	clinical and immunological efficiency of adamantane derivative in therapy of asthenic disorders in early forms of chronic brain ischemia
publisher	SPb RAACI
publishDate	2017
url	https://doaj.org/article/985bde6ab0b048fb897547a27ae7c9b8
work_keys_str_mv	AT evdavydova clinicalandimmunologicalefficiencyofadamantanederivativeintherapyofasthenicdisordersinearlyformsofchronicbrainischemia AT avzurochka clinicalandimmunologicalefficiencyofadamantanederivativeintherapyofasthenicdisordersinearlyformsofchronicbrainischemia
_version_	1718422368015089664

CLINICAL AND IMMUNOLOGICAL EFFICIENCY OF ADAMANTANE DERIVATIVE IN THERAPY OF ASTHENIC DISORDERS IN EARLY FORMS OF CHRONIC BRAIN ISCHEMIA

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