Lincomycin biosynthesis involves a tyrosine hydroxylating heme protein of an unusual enzyme family.

The gene lmbB2 of the lincomycin biosynthetic gene cluster of Streptomyces lincolnensis ATCC 25466 was shown to code for an unusual tyrosine hydroxylating enzyme involved in the biosynthetic pathway of this clinically important antibiotic. LmbB2 was expressed in Escherichia coli, purified near to ho...

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Autores principales: Jitka Novotna, Jana Olsovska, Petr Novak, Peter Mojzes, Radka Chaloupkova, Zdenek Kamenik, Jaroslav Spizek, Eva Kutejova, Marketa Mareckova, Pavel Tichy, Jiri Damborsky, Jiri Janata
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/985c474f95164d1dbd6ad0c2af5718a4
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