Effects of secretome derived from macrophages exposed to calcium oxalate crystals on renal fibroblast activation

Yoodee et al use label-free quantitative proteomics (nanoLC-ESI-LTQ-Orbitrap MS/MS) to identify 23 significantly altered secreted proteins from calcium oxalate monohydrate (COM)-exposed macrophages secretome. They demonstrate that proteins secreted from macrophages exposed to COM crystals induce ren...

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Autores principales:	Sunisa Yoodee, Chadanat Noonin, Kanyarat Sueksakit, Rattiyaporn Kanlaya, Sakdithep Chaiyarit, Paleerath Peerapen, Visith Thongboonkerd
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/985ca514504748529796d88d3acb337e
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spelling	oai:doaj.org-article:985ca514504748529796d88d3acb337e2021-12-02T15:07:46ZEffects of secretome derived from macrophages exposed to calcium oxalate crystals on renal fibroblast activation10.1038/s42003-021-02479-22399-3642https://doaj.org/article/985ca514504748529796d88d3acb337e2021-08-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02479-2https://doaj.org/toc/2399-3642Yoodee et al use label-free quantitative proteomics (nanoLC-ESI-LTQ-Orbitrap MS/MS) to identify 23 significantly altered secreted proteins from calcium oxalate monohydrate (COM)-exposed macrophages secretome. They demonstrate that proteins secreted from macrophages exposed to COM crystals induce renal fibroblast activation and may play important roles in renal fibrogenesis in kidney stone disease.Sunisa YoodeeChadanat NooninKanyarat SueksakitRattiyaporn KanlayaSakdithep ChaiyaritPaleerath PeerapenVisith ThongboonkerdNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Sunisa Yoodee Chadanat Noonin Kanyarat Sueksakit Rattiyaporn Kanlaya Sakdithep Chaiyarit Paleerath Peerapen Visith Thongboonkerd Effects of secretome derived from macrophages exposed to calcium oxalate crystals on renal fibroblast activation
description	Yoodee et al use label-free quantitative proteomics (nanoLC-ESI-LTQ-Orbitrap MS/MS) to identify 23 significantly altered secreted proteins from calcium oxalate monohydrate (COM)-exposed macrophages secretome. They demonstrate that proteins secreted from macrophages exposed to COM crystals induce renal fibroblast activation and may play important roles in renal fibrogenesis in kidney stone disease.
format	article
author	Sunisa Yoodee Chadanat Noonin Kanyarat Sueksakit Rattiyaporn Kanlaya Sakdithep Chaiyarit Paleerath Peerapen Visith Thongboonkerd
author_facet	Sunisa Yoodee Chadanat Noonin Kanyarat Sueksakit Rattiyaporn Kanlaya Sakdithep Chaiyarit Paleerath Peerapen Visith Thongboonkerd
author_sort	Sunisa Yoodee
title	Effects of secretome derived from macrophages exposed to calcium oxalate crystals on renal fibroblast activation
title_short	Effects of secretome derived from macrophages exposed to calcium oxalate crystals on renal fibroblast activation
title_full	Effects of secretome derived from macrophages exposed to calcium oxalate crystals on renal fibroblast activation
title_fullStr	Effects of secretome derived from macrophages exposed to calcium oxalate crystals on renal fibroblast activation
title_full_unstemmed	Effects of secretome derived from macrophages exposed to calcium oxalate crystals on renal fibroblast activation
title_sort	effects of secretome derived from macrophages exposed to calcium oxalate crystals on renal fibroblast activation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/985ca514504748529796d88d3acb337e
work_keys_str_mv	AT sunisayoodee effectsofsecretomederivedfrommacrophagesexposedtocalciumoxalatecrystalsonrenalfibroblastactivation AT chadanatnoonin effectsofsecretomederivedfrommacrophagesexposedtocalciumoxalatecrystalsonrenalfibroblastactivation AT kanyaratsueksakit effectsofsecretomederivedfrommacrophagesexposedtocalciumoxalatecrystalsonrenalfibroblastactivation AT rattiyapornkanlaya effectsofsecretomederivedfrommacrophagesexposedtocalciumoxalatecrystalsonrenalfibroblastactivation AT sakdithepchaiyarit effectsofsecretomederivedfrommacrophagesexposedtocalciumoxalatecrystalsonrenalfibroblastactivation AT paleerathpeerapen effectsofsecretomederivedfrommacrophagesexposedtocalciumoxalatecrystalsonrenalfibroblastactivation AT visiththongboonkerd effectsofsecretomederivedfrommacrophagesexposedtocalciumoxalatecrystalsonrenalfibroblastactivation
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Effects of secretome derived from macrophages exposed to calcium oxalate crystals on renal fibroblast activation

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