RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype
Enhanced cholesterol biosynthesis is associated with cancer progression. Here the authors identify the nuclear receptor RORγ as a novel master regulator of cholesterol metabolism in triple negative breast cancer (TNBC) and find that RORγ small-molecule antagonists induce tumor regression in patient-...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2019
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/985e83249405455e850f73d41a842e97 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:985e83249405455e850f73d41a842e97 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:985e83249405455e850f73d41a842e972021-12-02T16:57:46ZRORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype10.1038/s41467-019-12529-32041-1723https://doaj.org/article/985e83249405455e850f73d41a842e972019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12529-3https://doaj.org/toc/2041-1723Enhanced cholesterol biosynthesis is associated with cancer progression. Here the authors identify the nuclear receptor RORγ as a novel master regulator of cholesterol metabolism in triple negative breast cancer (TNBC) and find that RORγ small-molecule antagonists induce tumor regression in patient-derived xenografts and immunocompetent mouse models.Demin CaiJunjian WangBei GaoJin LiFeng WuJune X. ZouJianzhen XuYuqian JiangHongye ZouZenghong HuangAlexander D. BorowskyRichard J. BoldPrimo N. LaraJian Jian LiXinbin ChenKit S. LamKa-Fai ToHsing-Jien KungOliver FiehnRuqian ZhaoRonald M. EvansHong-Wu ChenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Demin Cai Junjian Wang Bei Gao Jin Li Feng Wu June X. Zou Jianzhen Xu Yuqian Jiang Hongye Zou Zenghong Huang Alexander D. Borowsky Richard J. Bold Primo N. Lara Jian Jian Li Xinbin Chen Kit S. Lam Ka-Fai To Hsing-Jien Kung Oliver Fiehn Ruqian Zhao Ronald M. Evans Hong-Wu Chen RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype |
| description |
Enhanced cholesterol biosynthesis is associated with cancer progression. Here the authors identify the nuclear receptor RORγ as a novel master regulator of cholesterol metabolism in triple negative breast cancer (TNBC) and find that RORγ small-molecule antagonists induce tumor regression in patient-derived xenografts and immunocompetent mouse models. |
| format |
article |
| author |
Demin Cai Junjian Wang Bei Gao Jin Li Feng Wu June X. Zou Jianzhen Xu Yuqian Jiang Hongye Zou Zenghong Huang Alexander D. Borowsky Richard J. Bold Primo N. Lara Jian Jian Li Xinbin Chen Kit S. Lam Ka-Fai To Hsing-Jien Kung Oliver Fiehn Ruqian Zhao Ronald M. Evans Hong-Wu Chen |
| author_facet |
Demin Cai Junjian Wang Bei Gao Jin Li Feng Wu June X. Zou Jianzhen Xu Yuqian Jiang Hongye Zou Zenghong Huang Alexander D. Borowsky Richard J. Bold Primo N. Lara Jian Jian Li Xinbin Chen Kit S. Lam Ka-Fai To Hsing-Jien Kung Oliver Fiehn Ruqian Zhao Ronald M. Evans Hong-Wu Chen |
| author_sort |
Demin Cai |
| title |
RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype |
| title_short |
RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype |
| title_full |
RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype |
| title_fullStr |
RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype |
| title_full_unstemmed |
RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype |
| title_sort |
rorγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/985e83249405455e850f73d41a842e97 |
| work_keys_str_mv |
AT demincai rorgisatargetablemasterregulatorofcholesterolbiosynthesisinacancersubtype AT junjianwang rorgisatargetablemasterregulatorofcholesterolbiosynthesisinacancersubtype AT beigao rorgisatargetablemasterregulatorofcholesterolbiosynthesisinacancersubtype AT jinli rorgisatargetablemasterregulatorofcholesterolbiosynthesisinacancersubtype AT fengwu rorgisatargetablemasterregulatorofcholesterolbiosynthesisinacancersubtype AT junexzou rorgisatargetablemasterregulatorofcholesterolbiosynthesisinacancersubtype AT jianzhenxu rorgisatargetablemasterregulatorofcholesterolbiosynthesisinacancersubtype AT yuqianjiang rorgisatargetablemasterregulatorofcholesterolbiosynthesisinacancersubtype AT hongyezou rorgisatargetablemasterregulatorofcholesterolbiosynthesisinacancersubtype AT zenghonghuang rorgisatargetablemasterregulatorofcholesterolbiosynthesisinacancersubtype AT alexanderdborowsky rorgisatargetablemasterregulatorofcholesterolbiosynthesisinacancersubtype AT richardjbold rorgisatargetablemasterregulatorofcholesterolbiosynthesisinacancersubtype AT primonlara rorgisatargetablemasterregulatorofcholesterolbiosynthesisinacancersubtype AT jianjianli rorgisatargetablemasterregulatorofcholesterolbiosynthesisinacancersubtype AT xinbinchen rorgisatargetablemasterregulatorofcholesterolbiosynthesisinacancersubtype AT kitslam rorgisatargetablemasterregulatorofcholesterolbiosynthesisinacancersubtype AT kafaito rorgisatargetablemasterregulatorofcholesterolbiosynthesisinacancersubtype AT hsingjienkung rorgisatargetablemasterregulatorofcholesterolbiosynthesisinacancersubtype AT oliverfiehn rorgisatargetablemasterregulatorofcholesterolbiosynthesisinacancersubtype AT ruqianzhao rorgisatargetablemasterregulatorofcholesterolbiosynthesisinacancersubtype AT ronaldmevans rorgisatargetablemasterregulatorofcholesterolbiosynthesisinacancersubtype AT hongwuchen rorgisatargetablemasterregulatorofcholesterolbiosynthesisinacancersubtype |
| _version_ |
1718382460485500928 |