Prevalence of Chronic Metabolic Comorbidities in Acute Pancreatitis and Its Impact on Early Gastrointestinal Symptoms during Hospitalization: A Prospective Cohort Study

Background: The prevalence of chronic comorbidities is increasing worldwide, and this has been paralleled by a growing interest in how these comorbidities affect patients with acute pancreatitis. The aim was to investigate the associations between pre-existing diabetes mellitus, obesity, metabolic s...

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Autores principales:	Rachel Goodger, Kanageswari Singaram, Maxim S. Petrov
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	acute pancreatitis diabetes mellitus obesity metabolic syndrome gastrointestinal symptoms patient-reported outcomes Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/985eb112d02d4536a5d69260b1c1e4fe
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spelling	oai:doaj.org-article:985eb112d02d4536a5d69260b1c1e4fe2021-11-25T07:47:20ZPrevalence of Chronic Metabolic Comorbidities in Acute Pancreatitis and Its Impact on Early Gastrointestinal Symptoms during Hospitalization: A Prospective Cohort Study2296-687010.1159/000519826https://doaj.org/article/985eb112d02d4536a5d69260b1c1e4fe2021-11-01T00:00:00Zhttps://www.karger.com/Article/FullText/519826https://doaj.org/toc/2296-6870Background: The prevalence of chronic comorbidities is increasing worldwide, and this has been paralleled by a growing interest in how these comorbidities affect patients with acute pancreatitis. The aim was to investigate the associations between pre-existing diabetes mellitus, obesity, metabolic syndrome, and gastrointestinal symptoms during the early course of acute pancreatitis. Methods: This was a prospective cohort study of patients with a primary diagnosis of acute pancreatitis. Study groups were formed based on the presence of metabolic comorbidities (pre-existing diabetes mellitus, obesity, and metabolic syndrome). Patient-reported outcomes (nausea, bloating, and abdominal pain) were collected prospectively every 24 h (including weekends and public holidays) over the first 72 h of hospitalization. Results: A total of 183 consecutive patients were enrolled. Of them, 111 (61%) had at least one major metabolic comorbidity. Patients with pre-existing diabetes mellitus and those with metabolic syndrome had worse nausea at 49–72 h of hospitalization (p = 0.017 and p = 0.012, respectively), but not at other time points. Bloating and abdominal pain did not differ between the study groupings throughout the study period. The studied patient-reported outcomes did not differ significantly between acute pancreatitis patients with and without obesity at any point in time. Conclusion: More than 3 out of 5 patients hospitalized for acute pancreatitis have at least one major chronic metabolic comorbidity. The presence of metabolic comorbidities does not considerably and consistently affect early gastrointestinal symptoms in patients with acute pancreatitis.Rachel GoodgerKanageswari SingaramMaxim S. PetrovKarger Publishersarticleacute pancreatitisdiabetes mellitusobesitymetabolic syndromegastrointestinal symptomspatient-reported outcomesMedicine (General)R5-920ENBiomedicine Hub, Vol 6, Iss 3, Pp 111-117 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acute pancreatitis diabetes mellitus obesity metabolic syndrome gastrointestinal symptoms patient-reported outcomes Medicine (General) R5-920
spellingShingle	acute pancreatitis diabetes mellitus obesity metabolic syndrome gastrointestinal symptoms patient-reported outcomes Medicine (General) R5-920 Rachel Goodger Kanageswari Singaram Maxim S. Petrov Prevalence of Chronic Metabolic Comorbidities in Acute Pancreatitis and Its Impact on Early Gastrointestinal Symptoms during Hospitalization: A Prospective Cohort Study
description	Background: The prevalence of chronic comorbidities is increasing worldwide, and this has been paralleled by a growing interest in how these comorbidities affect patients with acute pancreatitis. The aim was to investigate the associations between pre-existing diabetes mellitus, obesity, metabolic syndrome, and gastrointestinal symptoms during the early course of acute pancreatitis. Methods: This was a prospective cohort study of patients with a primary diagnosis of acute pancreatitis. Study groups were formed based on the presence of metabolic comorbidities (pre-existing diabetes mellitus, obesity, and metabolic syndrome). Patient-reported outcomes (nausea, bloating, and abdominal pain) were collected prospectively every 24 h (including weekends and public holidays) over the first 72 h of hospitalization. Results: A total of 183 consecutive patients were enrolled. Of them, 111 (61%) had at least one major metabolic comorbidity. Patients with pre-existing diabetes mellitus and those with metabolic syndrome had worse nausea at 49–72 h of hospitalization (p = 0.017 and p = 0.012, respectively), but not at other time points. Bloating and abdominal pain did not differ between the study groupings throughout the study period. The studied patient-reported outcomes did not differ significantly between acute pancreatitis patients with and without obesity at any point in time. Conclusion: More than 3 out of 5 patients hospitalized for acute pancreatitis have at least one major chronic metabolic comorbidity. The presence of metabolic comorbidities does not considerably and consistently affect early gastrointestinal symptoms in patients with acute pancreatitis.
format	article
author	Rachel Goodger Kanageswari Singaram Maxim S. Petrov
author_facet	Rachel Goodger Kanageswari Singaram Maxim S. Petrov
author_sort	Rachel Goodger
title	Prevalence of Chronic Metabolic Comorbidities in Acute Pancreatitis and Its Impact on Early Gastrointestinal Symptoms during Hospitalization: A Prospective Cohort Study
title_short	Prevalence of Chronic Metabolic Comorbidities in Acute Pancreatitis and Its Impact on Early Gastrointestinal Symptoms during Hospitalization: A Prospective Cohort Study
title_full	Prevalence of Chronic Metabolic Comorbidities in Acute Pancreatitis and Its Impact on Early Gastrointestinal Symptoms during Hospitalization: A Prospective Cohort Study
title_fullStr	Prevalence of Chronic Metabolic Comorbidities in Acute Pancreatitis and Its Impact on Early Gastrointestinal Symptoms during Hospitalization: A Prospective Cohort Study
title_full_unstemmed	Prevalence of Chronic Metabolic Comorbidities in Acute Pancreatitis and Its Impact on Early Gastrointestinal Symptoms during Hospitalization: A Prospective Cohort Study
title_sort	prevalence of chronic metabolic comorbidities in acute pancreatitis and its impact on early gastrointestinal symptoms during hospitalization: a prospective cohort study
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/985eb112d02d4536a5d69260b1c1e4fe
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Prevalence of Chronic Metabolic Comorbidities in Acute Pancreatitis and Its Impact on Early Gastrointestinal Symptoms during Hospitalization: A Prospective Cohort Study

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